- Cognitive assessment and quantitative magnetic resonance metrics can help to identify benign multiple sclerosis
[作者:Amato, MP; Portaccio, E; Stromillo, ML; Goretti, B; Zipoli, V; Siracusa, G; Battaglini, M; Giorgio, A; Bartolozzi, ML; Guidi, L; Sorbi, S; Federico, A; De Stefano, N,期刊:Neurology, 页码:632-638 , 文章类型: Article,,卷期:2008年71-9]
- Background: The definition of benign multiple sclerosis (B-MS) is still controversial. This mainly takes into account the subject's motor ability, with little or no relevance to other important features such as cognition...
- Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease
[作者:Brouwers, N; Sleegers, K; Engelborghs, S; Maurer-Stroh, S; Gijselinck, I; van der Zee, J; Pickut, BA; Van den Broeck, M; Mattheijssens, M; Peeters, K; Schymkowitz, J; Rousseau, F; Martin, JJ; Cruts, M; De Deyn, PP; Van Broeckhoven, C,期刊:Neurology, 页码:656-664 , 文章类型: Article,,卷期:2008年71-9]
- Objective: Loss-of-function mutations in the progranulin gene (PGRN) were identified in frontotemporal lobar degeneration (FTLD) with ubiquitin-immunoreactive neuronal inclusions (FTLD-U). We assessed whether PGRN also c...
- An unusual source of excess zinc, leading to hypocupremia and neurologic disease
[作者:Nations, SP; Boyer, PJ; Love, LA; Burritt, MF; Butz, JA; Wolfe, GI; Hynan, LS; Reisch, J; Trivedi, JR,期刊:Neurology, 页码:639-643 , 文章类型: Article,,卷期:2008年71-9]
- Background: Chronic, excess zinc intake can result in copper deficiency and profound neurologic disease. However, when hyperzincemia is identified, the source often remains elusive. We identified four patients, one previ...
- Second consensus statement on the diagnosis of multiple system atrophy
[作者:Gilman, S; Wenning, GK; Low, PA; Brooks, DJ; Mathias, CJ; Trojanowski, JQ; Wood, NW; Colosimo, C; Duerr, A; Fowler, CJ; Kaufmann, H; Klockgether, T; Lees, A; Poewe, W; Quinn, N; Revesz, T; Robertson, D; Sandroni, P; Seppi, K; Vidailhet, M,期刊:Neurology, 页码:670-676 , 文章类型: Article,,卷期:2008年71-9]
- Background: A consensus conference on multiple system atrophy (MSA) in 1998 established criteria for diagnosis that have been accepted widely. Since then, clinical, laboratory, neuropathologic, and imaging studies have a...
- Disability as an outcome in MS clinical trials
[作者:Ebers, GC; Heigenhauser, L; Daumer, M; Lederer, C; Noseworthy, JH,期刊:Neurology, 页码:624-631 , 文章类型: Article,,卷期:2008年71-9]
- Background: Inferences about long-term effects of therapies in multiple sclerosis (MS) have been based on surrogate markers studied in short-term trials. Preventing progressive disability is the key therapeutic goal but ...
- Gastrointestinal bleeding after acute ischemic stroke
[作者:O'Donnell, MJ; Kapral, MK; Fang, J; Saposnik, G; Eikelboom, JW; Oczkowski, W; Silva, J; Gould, L; D'Uva, C; Silver, FL,期刊:Neurology, 页码:650-655 , 文章类型: Article,,卷期:2008年71-9]
- Objective: Recent studies report that major bleeding is associated with a significant increase in mortality after acute coronary syndrome. Major bleeding has also been reported to be common after ischemic stroke, most of...
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