- Natural Variation within the Neuronal Nicotinic Acetylcholine Receptor Cluster on Human Chromosome 15q24: Influence on Heritable Autonomic Traits in Twin Pairs
[作者:Rana, BK; Wessel, J; Mahboubi, V; Rao, FW; Haeller, J; Gayen, JR; Eskin, E; Valle, AM; Das, M; Mahata, SK; Taupenot, L; Stridsberg, M; Talley, TT; Ziegler, MG; Smith, DW; Schork, NJ; O'Connor, DT; Taylor, P,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:419-428 , 文章类型: Article,,卷期:2009年331-2]
- Nicotinic acetylcholine receptors (nAChRs) are combinations of subunits arranged as pentamers encircling a central cation channel. At least nine alpha and four beta subunits are expressed in the central and peripheral ne...
- Extracellular Signal-Regulated Kinase 1/2 Activation Counteracts Morphine Tolerance in the Periaqueductal Gray of the Rat
[作者:Macey, TA; Bobeck, EN; Hegarty, DM; Aicher, SA; Ingram, SL; Morgan, MM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:412-418 , 文章类型: Article,,卷期:2009年331-2]
- Repeated administration of opioids produces long-lasting changes in mu-opioid receptor (MOR) signaling that underlie behavioral changes such as tolerance. Mitogen-activated protein kinase (MAPK) pathways, including MAPK ...
- Apoptotic Signaling Activated by Modulation of the F0F1-ATPase: Implications for Selective Killing of Autoimmune Lymphocytes
[作者:Sundberg, TB; Swenson, L; Wahl, DR; Opipari, AW; Glick, GD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:437-444 , 文章类型: Article,,卷期:2009年331-2]
- 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(napthalen-2-ylmetyl)4,5,-dihydro-1H-benzo[b][1,4]diazepin- 2(3H)-one (Bz- 423) is a proapoptotic 1,4-benzodiazepine that potently suppresses disease in the murine model of lupus b...
- Participation of Oxidative Stress on Rat Middle Cerebral Artery Changes Induced by Focal Cerebral Ischemia: Beneficial Effects of 3,4-Dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6)
[作者:Jimenez-Altayo, F; Caracuel, L; Perez-Asensio, FJ; Martinez-Revelles, S; Messeguer, A; Planas, AM; Vila, E,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:429-436 , 文章类型: Article,,卷期:2009年331-2]
- Cerebral ischemia followed by reperfusion alters vessel properties of brain arteries in rats, inducing an inflammatory response and excessive generation of reactive oxygen species. This study investigated the participati...
- Periodic, Partial Inhibition of I kappa B Kinase beta-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis
[作者:Gillooly, KM; Pattoli, MA; Taylor, TL; Chen, LS; Cheng, LH; Gregor, KR; Whitney, GS; Susulic, V; Watterson, SH; Kempson, J; Pitts, WJ; Booth-Lute, H; Yang, GC; Davies, P; Kukral, DW; Strnad, J; McIntyre, KW; Darienzo, CJ; Salter-Cid, L; Yang, Z; Wang-Iverson, DB; Burke, JR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:349-360 , 文章类型: Article,,卷期:2009年331-2]
- We have previously shown that inhibitors of I kappa B kinase beta(IKK beta), including 4(2'-aminoethyl) amino-1,8-dimethylimidazo(1,2-a) quinoxaline (BMS-345541), are efficacious against experimental arthritis in rodents...
- Capsaicin Protects Mouse Neuromuscular Junctions from the Neuroparalytic Effects of Botulinum Neurotoxin A
[作者:Thyagarajan, B; Krivitskaya, N; Potian, JG; Hognason, K; Garcia, CC; McArdle, JJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:361-371 , 文章类型: Article,,卷期:2009年331-2]
- Botulinum neurotoxin A (BoNT/A), the most toxic, naturally occurring protein, cleaves synapse-associated protein of 25 kDa and inhibits acetylcholine release from motor nerve endings (MNEs). This leads to paralysis of sk...
- Ranolazine Antagonizes the Effects of Increased Late Sodium Current on Intracellular Calcium Cycling in Rat Isolated Intact Heart
[作者:Wasserstrom, JA; Sharma, R; O'Toole, MJ; Zheng, JB; Kelly, JE; Shryock, J; Belardinelli, L; Aistrup, GL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:382-391 , 文章类型: Article,,卷期:2009年331-2]
- Pathological conditions, including ischemia and heart failure, are associated with altered sodium channel function and increased late sodium current (I-Na,I-L), leading to prolonged action potential duration, increased i...
- Targeted Detoxification of Selected Reactive Oxygen Species in the Vascular Endothelium
[作者:Shuvaev, VV; Christofidou-Solomidou, M; Bhora, F; Laude, K; Cai, H; Dikalov, S; Arguiri, E; Solomides, CC; Albelda, SM; Harrison, DG; Muzykantov, VR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:404-411 , 文章类型: Article,,卷期:2009年331-2]
- Oxidative stress underlies diverse vascular diseases, but its management remains elusive, in part because of our inability to selectively detoxify reactive oxygen species (ROS) in pathological sites and our limited under...
- Thioflavin S (NSC71948) Interferes with Bcl-2-Associated Athanogene (BAG-1)-Mediated Protein-Protein Interactions
[作者:Sharp, A; Crabb, SJ; Johnson, PWM; Hague, A; Cutress, R; Townsend, PA; Ganesan, A; Packham, G,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:680-689 , 文章类型: Article,,卷期:2009年331-2]
- The C-terminal BAG domain is thought to play a key role in BAG-1-induced survival and proliferation by mediating protein-protein interactions, for example, with heat shock proteins HSC70 and HSP70, and with RAF-1 kinase....
- Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling
[作者:Masood, A; Huang, Y; Hajjhussein, H; Xiao, L; Li, H; Wang, W; Hamza, A; Zhan, CG; O'Donnell, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:690-699 , 文章类型: Article,,卷期:2009年331-2]
- Phosphodiesterase (PDE)-2 is a component of the nitric-oxide synthase (NOS)/guanylyl cyclase signaling pathway in the brain. Given recent evidence that pharmacologically induced changes in NO-cGMP signaling can affect an...
- Discriminative Stimulus Effects of Psychostimulants and Hallucinogens in S(+)-3,4-Methylenedioxymethamphetamine (MDMA) and R(-)-MDMA Trained Mice
[作者:Murnane, KS; Murai, N; Howell, LL; Fantegrossi, WE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:717-723 , 文章类型: Article,,卷期:2009年331-2]
- 3,4-Methylenedioxymethamphetamine (MDMA) is a substituted phenethylamine more commonly known as the drug of abuse "ecstasy." The acute and persistent neurochemical effects of MDMA in the mice are distinct from those in o...
- Lymphatic Transport of Methylnortestosterone Undecanoate (MU) and the Bioavailability of Methylnortestosterone Are Highly Sensitive to the Mass of Coadministered Lipid after Oral Administration of MU
[作者:White, KL; Nguyen, G; Charman, WN; Edwards, GA; Faassen, WA; Porter, CJH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:700-709 , 文章类型: Article,,卷期:2009年331-2]
- The contribution of lymphatic transport to the oral bioavailability of methylnortestosterone (M) after oral administration of the lipophilic prodrug methylnortestosterone undecanoate (MU) has been evaluated, and the sens...
- A Novel Indole-3-propanamide Exerts Its Immunosuppressive Activity by Inhibiting JAK3 in T Cells
[作者:Carbonnelle, D; Duflos, M; Marchand, P; Chauvet, C; Petit, JY; Lang, F,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:710-716 , 文章类型: Article,,卷期:2009年331-2]
- We previously identified an indole-3-propanamide derivative, 3-[1-(4-chlorobenzyl)indol-3-yl]-N-(pyridin-4-yl)propanamide (AD412), as a potential immunosuppressive agent. Here, we document that AD412 inhibited the prolif...
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