- Combination Treatment with Normobaric Hyperoxia and Cilostazol Protects Mice against Focal Cerebral Ischemia-Induced Neuronal Damage Better Than Each Treatment Alone
[作者:Nonaka, Y; Koumura, A; Hyakkoku, K; Shimazawa, M; Yoshimura, S; Iwama, T; Hara, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:13-22 , 文章类型: Article,,卷期:2009年330-1]
- Normobaric hyperoxia (NBO) and cilostazol (6-[4-(1-cyclohexy-1H-tetrazol-5-yl) butoxyl]-3,4-dihydro-2-(1H)-quinolinone) (a selective inhibitor of phosphodiesterase 3) have each been reported to exert neuroprotective effe...
- Overexpression of Peroxiredoxin 6 Does Not Prevent Ethanol-Mediated Oxidative Stress and May Play a Role in Hepatic Lipid Accumulation
[作者:Roede, JR; Orlicky, DJ; Fisher, AB; Petersen, DR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:79-88 , 文章类型: Article,,卷期:2009年330-1]
- Oxidative stress is implicated in the etiology of many diseases, including alcoholic liver disease (ALD). Peroxiredoxin 6 is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lun...
- Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Parathyroid Hormone-Calcium Homeostasis in Rats and Humans
[作者:Abraham, AK; Mager, DE; Gao, X; Li, M; Healy, DR; Maurer, TS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:169-178 , 文章类型: Article,,卷期:2009年330-1]
- The purpose of this study was to develop a mechanism-based pharmacokinetic/pharmacodynamic model that describes the regulation of the parathyroid hormone (PTH)-Ca2+ system in rats and humans. Temporal concentration data ...
- What Are Next Generation Innovative Therapeutic Targets? Clues from Genetic, Structural, Physicochemical, and Systems Profiles of Successful Targets
[作者:Zhu, F; Han, LY; Zheng, CJ; Xie, B; Tammi, MT; Yang, SY; Wei, YQ; Chen, YZ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:304-315 , 文章类型: Article,,卷期:2009年330-1]
- Low target discovery rate has been linked to inadequate consideration of multiple factors that collectively contribute to druggability. These factors include sequence, structural, physicochemical, and systems profiles. M...
- Differential Modulation of Farnesoid X Receptor Signaling Pathway by the Thiazolidinediones
[作者:Kaimal, R; Song, XL; Yan, BF; King, R; Deng, RT,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:125-134 , 文章类型: Article,,卷期:2009年330-1]
- Thiazolidinediones (TZD), including troglitazone, rosiglitazone, and pioglitazone, are agonists of peroxisome proliferator-activated receptor (PPAR)-gamma and belong to a class of insulin-sensitizing drugs for type 2 dia...
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