- Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice
[作者:Wu, SL; Chen, JC; Li, CC; Lo, HY; Ho, TY; Hsiang, CY,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:370-376 , 文章类型: Article,,卷期:2009年330-2]
- Inflammatory bowel disease (IBD) is chronic inflammatory and relapsing disease of the gut. It has been known that activation of nuclear factor-kappa B (NF-kappa B) and production of proinflammatory cytokines play importa...
- Dynamic Assessment of Mitoxantrone Resistance and Modulation of Multidrug Resistance by Valspodar (PSC833) in Multidrug Resistance Human Cancer Cells
[作者:Shen, F; Bailey, BJ; Chu, SY; Bence, AK; Xue, XJ; Erickson, P; Safa, AR; Beck, WT; Erickson, LC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:423-429 , 文章类型: Article,,卷期:2009年330-2]
P-glycoprotein (Pgp), a member of the ATP-binding cassette transporter family, is one of the major causes for multidrug resistance (MDR). We report using confocal microscopy to study the roles of Pgp in mediating the ...
- Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster
[作者:King, AJ; Segreti, JA; Larson, KJ; Souers, AJ; Kym, PR; Reilly, RM; Zhao, G; Mittelstadt, SW; Cox, BF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:526-531 , 文章类型: Article,,卷期:2009年330-2]
- Acyl CoA/diacylglycerol acyltransferase (DGAT) 1 is one of two known DGAT enzymes that catalyze the final and only committed step in triglyceride biosynthesis. The purpose of this study was to test the hypothesis that ch...
- Pregnancy Does Not Increase CYP3A or P-Glycoprotein Activity in the Non-Human Primate, Macaca nemestrina
[作者:Zhang, HX; Wu, XH; Naraharisetti, SB; Chung, F; Whittington, D; Mirfazaelian, A; Unadkat, JD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:586-595 , 文章类型: Article,,卷期:2009年330-2]
- Plasma concentrations of protease inhibitors are lower in pregnant women than in nonpregnant women or men. Using nelfi-navir as a model protease inhibitor, we have shown that this phenomenon can be reproduced in a repres...
- Eosinophil-Selective Binding and Proapoptotic Effect in Vitro of a Synthetic Siglec-8 Ligand, Polymeric 6 '-Sulfated Sialyl Lewis X
[作者:Hudson, SA; Bovin, NV; Schnaar, RL; Crocker, PR; Bochner, BS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:608-612 , 文章类型: Article,,卷期:2009年330-2]
- The lectin Siglec-8 (sialic acid-binding, immunoglobulin-like lectin), which is selectively expressed on eosinophil surfaces and regulates eosinophil survival, preferentially binds to the glycan 6'-sulfo-sialyl Lewis X (...
- Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period
[作者:Walton, KM; Fisher, K; Rubitski, D; Marconi, M; Meng, QJ; Sladek, M; Adams, J; Bass, M; Chandrasekaran, R; Butler, T; Griffor, M; Rajamohan, F; Serpa, M; Chen, Y; Claffey, M; Hastings, M; Loudon, A; Maywood, E; Ohren, J; Doran, A; Wager, TT,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:430-439 , 文章类型: Article,,卷期:2009年330-2]
- The circadian clock links our daily cycles of sleep and activity to the external environment. Deregulation of the clock is implicated in a number of human disorders, including depression, seasonal affective disorder, and...
- (S)-1-(alpha-Naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) Reduces Rat Myocardial Apoptosis against Ischemia and Reperfusion Injury by Activation of Phosphatidylinositol 3-Kinase/Akt Signaling and Anti-inflammatory Action in Vivo
[作者:Jin, YC; Lee, YS; Kim, YM; Seo, HG; Lee, JH; Kim, HJ; Yun-Choi, HS; Chang, KC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:440-448 , 文章类型: Article,,卷期:2009年330-2]
We examined our hypothesis that (S)-1-(alpha-naphthylmethyl)-6,7dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) inhibits apoptosis in myocardial ischemia and reperfusion (I/R) injury in vivo via activation of the ph...
- The Effects of Repeated Opioid Administration on Locomotor Activity: II. Unidirectional Cross-Sensitization to Cocaine
[作者:Smith, MA; Greene-Naples, JL; Felder, JN; Iordanou, JC; Lyle, MA; Walker, KL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:476-486 , 文章类型: Article,,卷期:2009年330-2]
- Sensitization refers to an increase in sensitivity to the effects of a drug and is believed to play a role in the etiology of substance use disorders. Cross-sensitization has been observed between drugs from different ph...
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