- Maternal Exposure to Dioxin Disrupts Gonadotropin Production in Fetal Rats and Imprints Defects in Sexual Behavior
[作者:Takeda, T; Matsumoto, Y; Koga, T; Mutoh, J; Nishimura, Y; Shimazoe, T; Ishii, Y; Ishida, T; Yamada, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1091-1099 , 文章类型: Article,,卷期:2009年329-3]
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related substances are a class of environmental pollutants with suspected toxic effects on reproductive and developmental processes. This study investigated a hypothesis ...
- An Orally Bioavailable Synthetic Analog of an Active Dehydroepiandrosterone Metabolite Reduces Established Disease in Rodent Models of Rheumatoid Arthritis
[作者:Offner, H; Firestein, GS; Boyle, DL; Pieters, R; Frincke, JM; Garsd, A; White, SK; Reading, CL; Auci, DL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1100-1109 , 文章类型: Article,,卷期:2009年329-3]
Dehydroepiandrosterone (DHEA) treatment provides diverse anti-inflammatory benefits in rodent models of diseases, including rheumatoid arthritis (RA), but only limited benefits to patients. In rodents, DHEA is metabol...
- Essential Role of the 90-Kilodalton Heat Shock Protein in Mediating Nongenomic Estrogen Signaling in Coronary Artery Smooth Muscle
[作者:Han, GC; Ma, HD; Chintala, R; Fulton, DJR; Barman, SA; White, RE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:850-855 , 文章类型: Article,,卷期:2009年329-3]
Under normal physiological conditions, estrogen is a coronary vasodilator, and this response involves production of NO from endothelial cells. In addition, estrogen also stimulates NO production in coronary artery smo...
- Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rodent Model of Postoperative Ileus
[作者:Venkova, K; Mann, W; Nelson, R; Greenwood-Van Meerveld, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1110-1116 , 文章类型: Article,,卷期:2009年329-3]
Ghrelin and ghrelin mimetics stimulate appetite and enhance gastric motility. The present study investigates whether ipamorelin, a selective growth hormone secretagogue and agonist of the ghrelin receptor, would accel...
- The Free Radical Scavenger Edaravone Rescues Rats from Cerebral Infarction by Attenuating the Release of High-Mobility Group Box-1 in Neuronal Cells
[作者:Kikuchi, K; Kawahara, K; Tancharoen, S; Matsuda, F; Morimoto, Y; Ito, T; Biswas, KK; Takenouchi, K; Miura, N; Oyama, Y; Nawa, Y; Arimura, N; Iwata, M; Tajima, Y; Kuramoto, T; Nakayama, K; Shigemori, M; Yoshida, Y; Hashiguchi, T; Maruyama, I,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:865-874 , 文章类型: Article,,卷期:2009年329-3]
Edaravone, a potent free radical scavenger, is clinically used for the treatment of cerebral infarction in Japan. Here, we examined the effects of edaravone on the dynamics of high-mobility group box-1 (HMGB1), which ...
- The Ceiling Effect of Pharmacological Postconditioning with the Phytoestrogen Genistein Is Reversed by the GSK3 beta Inhibitor SB 216763 [3-(2,4-Dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through Mitochondrial ATP-Dependent Potassium Channel Opening
[作者:Couvreur, N; Tissier, R; Pons, S; Chenoune, M; Waintraub, X; Berdeaux, A; Ghaleh, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1134-1141 , 文章类型: Article,,卷期:2009年329-3]
In the present study, we investigated the efficacy of pharmacological postconditioning induced by 17 beta-estradiol and the phytoestrogen, genistein, against myocardial infarction induced by increasing durations of co...
- Sepiapterin Decreases Acute Rejection and Apoptosis in Cardiac Transplants Independently of Changes in Nitric Oxide and Inducible Nitric-Oxide Synthase Dimerization
[作者:Pieper, GM; Ionova, IA; Cooley, BC; Migrino, RQ; Khanna, AK; Whitsett, J; Vasquez-Vivar, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:890-899 , 文章类型: Article,,卷期:2009年329-3]
Tetrahydrobiopterin (BH4), a cofactor of inducible nitric-oxide synthase (iNOS), is an important post-translational regulator of NO bioactivity. We examined whether treatment of cardiac allograft recipients with sepia...
- Differential Localization of Flavin-Containing Monooxygenase (FMO) Isoforms 1, 3, and 4 in Rat Liver and Kidney and Evidence for Expression of FMO4 in Mouse, Rat, and Human Liver and Kidney Microsomes
[作者:Novick, RM; Mitzey, AM; Brownfield, MS; Elfarra, AA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1148-1155 , 文章类型: Article,,卷期:2009年329-3]
Flavin-containing monooxygenases (FMOs) play significant roles in the metabolism of drugs and endogenous or foreign compounds. In this study, the regional distribution of FMO isoforms 1, 3, and 4 was investigated in m...
- Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Strong Activity against Human Cancers in Vitro and in Vivo
[作者:Chen, C; Li, GL; Liao, WM; Wu, J; Liu, L; Ma, D; Zhou, JF; Elbekai, RH; Edin, ML; Zeldin, DC; Wang, DW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:908-918 , 文章类型: Article,,卷期:2009年329-3]
The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs). We found recently that this enzyme is dramatically up-regulated in a variety of established hu...
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