- The Neuroprotective Effects of Benzylideneacetophenone Derivatives on Excitotoxicity and Inflammation via Phosphorylated Janus Tyrosine Kinase 2/Phosphorylated Signal Transducer and Activator of Transcription 3 and Mitogen-Activated Protein K Pathways
[作者:Jang, S; Jung, JC; Kim, DH; Ryu, JH; Lee, Y; Jung, M; Oh, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:435-447 , 文章类型: Article,,卷期:2009年328-2]
To search for new neuroprotective compounds, novel benzyli-deneacetophenone compounds (JCI, (3E)-4-(4-hydroxy-3-methoxyphenyl) but-3-en-2-one; JC2, (1E)-1-(4-hydroxy-3-methoxyphenyl) hept-1-en-3-one; JC3, (2E)-3-(4-hy...
- Vitamin D-3 Modulates the Expression of Bile Acid Regulatory Genes and Represses Inflammation in Bile Duct-Ligated Mice
[作者:Ogura, M; Nishida, S; Ishizawa, M; Sakurai, K; Shimizu, M; Matsuo, S; Amano, S; Uno, S; Makishima, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:564-570 , 文章类型: Article,,卷期:2009年328-2]
Vitamin D receptor (VDR), a nuclear receptor that regulates calcium homeostasis, has been found to function as a receptor for secondary bile acids. Because the in vivo role of VDR in bile acid metabolism remains unkno...
- Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development
[作者:Maran, RRM; Thomas, A; Roth, M; Sheng, ZH; Esterly, N; Pinson, D; Gao, X; Zhang, YW; Ganapathy, V; Gonzalez, FJ; Guo, GL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:469-477 , 文章类型: Article,,卷期:2009年328-2]
Increased dietary fat consumption is associated with colon cancer development. The exact mechanism by which fat induces colon cancer is not clear, however, increased bile acid excretion in response to high-fat diet ma...
- Regulation of Plasma Fructose and Mortality in Mice by the Aldose Reductase Inhibitor Lidorestat
[作者:Noh, HL; Hu, YY; Park, TS; DiCioccio, T; Nichols, AJ; Okajima, K; Homma, S; Goldberg, IJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:496-503 , 文章类型: Article,,卷期:2009年328-2]
Aldose reductase (AR), an enzyme widely believed to be involved in the aberrant metabolism of glucose and development of diabetic complications, is expressed at low levels in the mouse. We studied whether expression o...
- Parstatin, the Cleaved Peptide on Proteinase-Activated Receptor 1 Activation, Is a Potent Inhibitor of Angiogenesis
[作者:Zania, P; Gourni, D; Aplin, AC; Nicosia, RF; Flordellis, CS; Maragoudakis, ME; Tsopanoglou, NE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:378-389 , 文章类型: Article,,卷期:2009年328-2]
The proteolytic activation by thrombin of the proteinase-activated receptor 1 unveils the tethered peptide ligand and cleaves a 41-amino acid peptide. In this report, we show that this peptide, which we have designate...
- Carbendazim Inhibits Cancer Cell Proliferation by Suppressing Microtubule Dynamics
[作者:Yenjerla, M; Cox, C; Wilson, L; Jordan, MA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:390-398 , 文章类型: Article,,卷期:2009年328-2]
Carbendazim ( methyl 2-benzimidazolecarbamate) is widely used as a systemic fungicide in human food production and appears to act on fungal tubulin. However, it also inhibits proliferation of human cancer cells, inclu...
- Acute Toxicity of Organophosphorus Compounds in Guinea Pigs Is Sex- and Age-Dependent and Cannot Be Solely Accounted for by Acetylcholinesterase Inhibition
[作者:Fawcett, WP; Aracava, Y; Adler, M; Pereira, EFR; Albuquerque, EX,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:516-524 , 文章类型: Article,,卷期:2009年328-2]
This study was designed to test the hypothesis that the acute toxicity of the nerve agents S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioate (VX), O-pinacolyl methylphosphonofluoridate (soman), and O-isopro...
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