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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共41条记录   ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury [作者：Noma, K; Rikitake, Y; Oyama, N; Yan, GJ; Alcaide, P; Liu, PY; Wang, HW; Ahl, D; Sawada, N; Okamoto, F; Hiroi, Y; Shimizu, K; Luscinskas, FW; Sun, JX; Liao, JK,期刊：Journal of clinical investigation, 页码：1632-1644 , 文章类型： Article，,卷期：2008年118-5] Although Rho-associated kinase (ROCK) activity has been implicated in cardiovascular diseases, the tissue-and isoform-specific roles of ROCKs in the vascular response to injury are not known. To address the role of ROCKs... Adiponectin regulates albuminuria and podocyte function in mice [作者：Sharma, K; RamachandraRao, S; Qiu, G; Usui, HK; Zhu, YQ; Dunn, SR; Ouedraogo, R; Hough, K; McCue, P; Chan, L; Falkner, B; Goldstein, BJ,期刊：Journal of clinical investigation, 页码：1645-1656 , 文章类型： Article，,卷期：2008年118-5] Increased albuminuria is associated with obesity and diabetes and is a risk factor for cardiovascular and renal disease. However, the link between early albuminuria and adiposity remains unclear. To determine whether adi... Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells [作者：Ichimura, T; Asseldonk, EJPV; Humphreys, BD; Gunaratnam, L; Duffield, JS; Bonventre, JV,期刊：Journal of clinical investigation, 页码：1657-1668 , 文章类型： Article，,卷期：2008年118-5] Following injury, the clearance of apoptotic and necrotic cells is necessary for mitigation and resolution of inflammation and tissue repair. In addition to macrophages, which are traditionally assigned to this task, nei... A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy [作者：Fritsch, A; Loeckermann, S; Kern, JS; Braun, A; Bosl, MR; Bley, TA; Schumann, H; von Elverfeldt, D; Paul, D; Erlacher, M; von Rautenfeld, DB; Hausser, I; Fassler, R; Bruckner-Tuderman, L,期刊：Journal of clinical investigation, 页码：1669-1679 , 文章类型： Article，,卷期：2008年118-5] Dystrophic epidermolysis bullosa (DEB) is a severe skin fragility disorder associated with trauma-induced blistering, progressive soft tissue scarring, and increased risk of skin cancer. DEB is caused by mutations in typ... The type IIFN induction pathway constrains Th17-mediated autoimmune inflammation in mice [作者：Guo, BC; Chang, EY; Cheng, GH,期刊：Journal of clinical investigation, 页码：1680-1690 , 文章类型： Article，,卷期：2008年118-5] IFN-beta, a type I IFN, is widely used for the treatment of MS. However, the mechanisms behind its therapeutic efficacy are not well understood. Using a murine model of MS, EAE, we demonstrate that the Th17-mediated deve... Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice [作者：Hamzah, J; Nelson, D; Moldenhauer, G; Arnold, B; Hammerling, GJ; Ganss, R,期刊：Journal of clinical investigation, 页码：1691-1699 , 文章类型： Article，,卷期：2008年118-5] Current anticancer therapy is a delicate balance between elimination of malignant cells and harmful side effects for the host. In this study, we used a tumor-homing peptide to engineer anti-CD40 agonist antibodies and re... Antibody association with HER-2/neu-targeted vaccine enhances CD8(+) T cell responses in mice through Fc-mediated activation of DCs [作者：Kim, PS; Armstrong, TD; Song, H; Wolpoe, ME; Weiss, V; Manning, EA; Huang, LQ; Murata, S; Sgouros, G; Emens, LA; Reilly, RT; Jaffee, EM,期刊：Journal of clinical investigation, 页码：1700-1711 , 文章类型： Article，,卷期：2008年118-5] The pathogenic nature of cancer is attributed, at least in part, to the ability of tumors cells to induce systemic and local mechanisms of immune tolerance. However, we previously reported that tumor-free survival in up ... Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPAR gamma/STAT5 signaling pathway in macaques [作者：Prost, S; Le Dantec, M; Auge, S; Le Grand, R; Derdouch, S; Auregan, G; Deglon, N; Relouzat, F; Aubertin, AM; Maillere, B; Dusanter-Fourt, I; Kirszenbaum, M,期刊：Journal of clinical investigation, 页码：1765-1775 , 文章类型： Article，,卷期：2008年118-5] Infection of primates by HIV-1 and SIV induces multiple hematological abnormalities of central hematopoietic origin. Although these defects greatly contribute to the pathophysiology of HIV-1 infection, the molecular basi... Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection [作者：Samuelsson, C; Hausmann, J; Lauterbach, H; Schmidt, M; Akira, S; Wagner, H; Chaplin, P; Suter, M; O'Keeffe, M; Hochrein, H,期刊：Journal of clinical investigation, 页码：1776-1784 , 文章类型： Article，,卷期：2008年118-5] Poxviruses such as the causative agent of smallpox have developed multiple strategies to suppress immune responses, including the suppression of DC activation. Since poxviruses are large DNA viruses, we hypothesized t... Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire [作者：Su, MA; Giang, K; Zumer, K; Jiang, H; Oven, I; Rinn, JL; DeVoss, JJ; Johannes, KPA; Lu, W; Gardner, J; Chang, A; Bubulya, P; Chang, HY; Peterlin, BM; Anderson, MS,期刊：Journal of clinical investigation, 页码：1712-1726 , 文章类型： Article，,卷期：2008年118-5] Homozygous loss-of-function mutations in AIRE cause autoimmune polyglandular syndrome type 1 (APS 1), which manifests in a classic triad of hypoparathyroidism, adrenal insufficiency, and candidiasis. Interestingly, a kin... STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice [作者：Ernst, M; Najdovska, M; Grail, D; Lundgren-May, T; Buchert, M; Tye, H; Matthews, VB; Armes, J; Bhathal, PS; Hughes, NR; Marcusson, EG; Karras, JG; Na, SQ; Sedgwick, JD; Hertzog, PJ; Jenkins, BJ,期刊：Journal of clinical investigation, 页码：1727-1738 , 文章类型： Article，,卷期：2008年118-5] Deregulated activation of STAT3 is frequently associated with many human hematological and epithelial malignancies, including gastric cancer. While exaggerated STAT3 signaling facilitates an antiapoptotic, proangiogenic,... BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas [作者：Pfister, S; Janzarik, WG; Remke, M; Ernst, A; Werft, W; Becker, N; Toedt, G; Wittmann, A; Kratz, C; Olbrich, H; Ahmadi, R; Thieme, B; Joos, S; Radiwimmer, B; Kulozik, A; Pietsch, T; Herold-Mende, C; Gnekow, A; Reifenberger, G; Korshunov, A; Scheurlen, W; Omran, H; Lichter, P,期刊：Journal of clinical investigation, 页码：1739-1749 , 文章类型： Article，,卷期：2008年118-5] The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further understand the genetic abnormalities associated with these tumors, we performed a genome-wide analysis of DNA copy number aberra... Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity [作者：Tiedemann, RE; Mao, XL; Shi, CX; Zhu, YX; Palmer, SE; Sebag, M; Marler, R; Chesi, M; Fonseca, R; Bergsagel, PL; Schimmer, AD; Stewart, AK,期刊：Journal of clinical investigation, 页码：1750-1764 , 文章类型： Article，,卷期：2008年118-5] Knockout and transgenic studies in mice demonstrate that normal somatic tissues redundantly express 3 cyclin D proteins, whereas tumor cells seem dependent on a single overexpressed cyclin D. Thus, selective suppression ... Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice [作者：Ghosh, A; Li, W; Febbraio, M; Espinola, RG; McCrae, KR; Cockrell, E; Silverstein, RL,期刊：Journal of clinical investigation, 页码：1934-1943 , 文章类型： Article，,卷期：2008年118-5] CD36 is a scavenger receptor that binds multiple ligands, including phosphatidyl serine (PS). Although CD36(-) mice do not have a bleeding diathesis, we show here that they do have significantly prolonged thrombotic occl... Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice [作者：Otsuka, M; Zheng, M; Hayashi, M; Lee, JD; Yoshino, O; Lin, S; Han, J,期刊：Journal of clinical investigation, 页码：1944-1954 , 文章类型： Article，,卷期：2008年118-5] The microRNA (miRNA) processing enzyme Dicer1 is required for zygotic and embryonic development, but the early embryonic lethality of Dicer1 null alleles in mice has limited our ability to address the role of Dicer1 in n... Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice [作者：Allocca, M; Doria, M; Petrillo, M; Colella, P; Garcia-Hoyos, M; Gibbs, D; Kim, SR; Maguire, A; Rex, TS; Di Vicino, U; Cutillo, L; Sparrow, JR; Williams, DS; Bennett, J; Auricchio, A,期刊：Journal of clinical investigation, 页码：1955-1964 , 文章类型： Article，,卷期：2008年118-5] Vectors derived from adeno-associated virus (AAV) are promising for human gene therapy, including treatment for retinal blindness. One major limitation of AAVs as vectors is that AAV cargo capacity has been considered to...