- Paraspeckle protein p54(nrb) links Sox9-mediated transcription with RNA processing during chondrogenesis in mice
[作者:Hata, K; Nishimura, R; Muramatsu, S; Matsuda, A; Matsubara, T; Amano, K; Ikeda, F; Harley, VR; Yoneda, T,期刊:Journal of clinical investigation, 页码:3098-3108 , 文章类型: Article,,卷期:2008年118-9]
- The Sox9 transcription factor plays an essential role in promoting chondrogenesis and regulating expression of chondrocyte extracellular-matrix genes. To identify genes that interact with Sox9 in promoting chondrocyte di...
- Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins
[作者:Ziegler, DS; Wright, RD; Kesari, S; Lemieux, ME; Tran, MA; Jain, M; Zawel, L; Kung, AL,期刊:Journal of clinical investigation, 页码:3109-3122 , 文章类型: Article,,卷期:2008年118-9]
- Multiple receptor tyrosine kinases (RTKs), including PDGFR, have been validated as therapeutic targets in glioblastoma multiforme (GBM), yet inhibitors of RTKs have had limited clinical success. As various antiapoptotic ...
- Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1
[作者:Stoltz, DA; Ozer, EA; Taft, PJ; Barry, M; Liu, L; Kiss, PJ; Moninger, TO; Parsek, MR; Zabner, J,期刊:Journal of clinical investigation, 页码:3123-3131 , 文章类型: Article,,卷期:2008年118-9]
- Pseudomonas aeruginosa uses quorum sensing, an interbacterial communication system, to regulate gene expression. The signaling molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) is thought to play a central role i...
- Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
[作者:Hacein-Bey-Abina, S; Garrigue, A; Wang, GP; Soulier, J; Lim, A; Morillon, E; Clappier, E; Caccavelli, L; Delabesse, E; Beldjord, K; Asnafi, V; Macintyre, E; Dal Cortivo, L; Radford, I; Brousse, N; Sigaux, F; Moshous, D; Hauer, J; Borkhardt, A; Belohradsky, BH; Wintergerst, U; Velez, MC; Leiva, L; Sorensen, R; Wulffraat, N; Blanche, S; Bushman, FD; Fischer, A; Cavazzana-Calvo, M,期刊:Journal of clinical investigation, 页码:3132-3142 , 文章类型: Article,,卷期:2008年118-9]
- Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor gamma (IL2RG) gene to CD34(+) BM precursor cells using gammaretroviral vectors. While 9 of 10...
- The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans
[作者:Toyama, K; Wulff, H; Chandy, KG; Azam, P; Raman, G; Saito, T; Fujiwara, Y; Mattson, DL; Das, S; Melvin, JE; Pratt, PF; Hatoum, OA; Gutterman, DD; Harder, DR; Miura, H,期刊:Journal of clinical investigation, 页码:3025-3037 , 文章类型: Article,,卷期:2008年118-9]
- Atherosclerosis remains a major cause of death in the developed world despite the success of therapies that lower cholesterol and BP. The intermediate-conductance calcium-activated potassium channel KCa3.1 is expressed i...
- Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL(+) leukemia cells
[作者:Kharas, MG; Janes, MR; Scarfone, VM; Lilly, MB; Knight, ZA; Shokat, KM; Fruman, DA,期刊:Journal of clinical investigation, 页码:3038-3050 , 文章类型: Article,,卷期:2008年118-9]
- Some cases of pre-B cell acute lymphoblastic leukemia (pre-B-ALL) are caused by the Philadelphia (Ph) chromosome-encoded BCR-ABL oncogene, and these tend to have a poor prognosis. Inhibitors of the PI3K/AKT pathway reduc...
- Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
[作者:Kinkade, CW; Castillo-Martin, M; Puzio-Kuter, A; Yan, J; Foster, TH; Gao, H; Sun, Y; Ouyang, XS; Gerald, WL; Cordon-Cardo, C; Abate-Shen, C,期刊:Journal of clinical investigation, 页码:3051-3064 , 文章类型: Article,,卷期:2008年118-9]
- The AKT/mammalian target of rapamycin (AKT/mTOR) and ERK MAPK signaling pathways have been shown to cooperate in prostate cancer progression and the transition to androgen-independent disease. We have now tested the effe...
- Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
[作者:Carracedo, A; Ma, L; Teruya-Feldstein, J; Rojo, F; Salmena, L; Alimonti, A; Egia, A; Sasaki, AT; Thomas, G; Kozma, SC; Papa, A; Nardella, C; Cantley, LC; Baselga, J; Pandolfi, PP,期刊:Journal of clinical investigation, 页码:3065-3074 , 文章类型: Article,,卷期:2008年118-9]
- Numerous studies have established a causal link between aberrant mammalian target of rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have therapeutic potential. In this study, we show t...
- Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice
[作者:Kim, SJ; Zhang, ZJ; Sarkar, C; Tsai, PC; Lee, YC; Dye, L; Mukherjee, AB,期刊:Journal of clinical investigation, 页码:3075-3086 , 文章类型: Article,,卷期:2008年118-9]
- Neuronal ceroid lipofuscinoses represent the most common childhood neurodegenerative storage disorders. Infantile neuronal ceroid lipofuscinosis (INCL) is caused by palmitoyl protein thioesterase-1 (PPT1) deficiency. Alt...
- HsP104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
[作者:Lo Bianco, C; Shorter, J; Regulier, E; Lashuel, H; Iwatsubo, T; Lindquist, S; Aebischer, P,期刊:Journal of clinical investigation, 页码:3087-3097 , 文章类型: Article,,卷期:2008年118-9]
- Parkinson disease (PD) is characterized by dopaminergic neurodegeneration and intracellular inclusions of alpha-synuclein amyloid fibers, which are stable and difficult to dissolve. Whether inclusions are neuroprotective...
- Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
[作者:Howe, SJ; Mansour, MR; Schwarzwaelder, K; Bartholomae, C; Hubank, M; Kempski, H; Brugman, MH; Pike-Overzet, K; Chatters, SJ; de Ridder, D; Gilmour, KC; Adams, S; Thornhill, SI; Parsley, KL; Staal, FJT; Gale, RE; Linch, DC; Bayford, J; Brown, L; Quaye, M; Kinnon, C; Ancliff, P; Webb, DK; Schmidt, M; von Kalle, C; Gaspar, HB; Thrasher, AJ,期刊:Journal of clinical investigation, 页码:3143-3150 , 文章类型: Article,,卷期:2008年118-9]
- X-linked SCID (SCID-X1) is amenable to correction by gene therapy using conventional gammaretroviral vectors. Here, we describe the occurrence of clonal T cell acute lymphoblastic leukemia (T-ALL) promoted by insertional...
- The PKC inhibitor AEB071 may be a therapeutic option for psoriasis
[作者:Skvara, H; Dawid, M; Kleyn, E; Wolff, B; Meingassner, JG; Knight, H; Dumortier, T; Kopp, T; Fallahi, N; Stary, G; Burkhart, C; Grenet, O; Wagner, J; Hijazi, Y; Morris, RE; McGeown, C; Rordorf, C; Griffiths, CEM; Stingl, G; Jung, T,期刊:Journal of clinical investigation, 页码:3151-3159 , 文章类型: Article,,卷期:2008年118-9]
- PKC isoforms tau, alpha, and beta play fundamental roles in the activation of T cells and other immune cell functions. Here we show that the PKC inhibitor AEB071 both abolishes the production of several cytokines by acti...
- Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
[作者:Osei-Hyiaman, D; Liu, J; Zhou, L; Godlewski, G; Harvey-White, J; Jeong, WI; Batkai, S; Marsicano, G; Lutz, B; Buettner, C; Kunos, G,期刊:Journal of clinical investigation, 页码:3160-3169 , 文章类型: Article,,卷期:2008年118-9]
- Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile. Endocannabinoids have been implicated in the development of these associated phenotypes, be...
- Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice
[作者:Craig, DH; Owen, CR; Conway, WC; Walsh, MF; Downey, C; Basson, MD,期刊:Journal of clinical investigation, 页码:3170-3180 , 文章类型: Article,,卷期:2008年118-9]
- Iatrogenic tumor cell implantation within surgical wounds can compromise curative cancer surgery. Adhesion of cancer cells, in particular colon cancer cells, is stimulated by exposure to increased extracellular pressure ...
- Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
[作者:Chiang, MY; Xu, LW; Shestova, O; Histen, G; L'Heureux, S; Romany, C; Childs, ME; Gimotty, PA; Aster, JC; Pear, WS,期刊:Journal of clinical investigation, 页码:3181-3194 , 文章类型: Article,,卷期:2008年118-9]
- Gain-of-function NOTCH1 mutations are found in 50%-70% of human T cell acute lymphoblastic leukemia/ lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in mice...
|