- Human tRNA(UUU)(LYs3) Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto-Enol Tautomerism
[作者:Vendeix, FAP; Murphy, FV; Cantara, WA; Leszczynska, G; Gustilo, EM; Sproat, B; Malkiewicz, A; Agris, PF,期刊:Journal of Molecular Biology, 页码:467-485 , 文章类型: Article,,卷期:2012年416-4]
- Human tRNA(UUU)(LYs3) (htRNA(UUU)(LYs3)) decodes the lysine codons AAA and AAG during translation and also plays a crucial role as the primer for HIV-1 (human immunodeficiency virus type 1) reverse transcription. The pos...
- Engineering Domain-Swapped Binding Interfaces by Mutually Exclusive Folding
[作者:Ha, JH; Karchin, JM; Walker-Kopp, N; Huang, LS; Berry, EA; Loh, SN,期刊:Journal of Molecular Biology, 页码:495-502 , 文章类型: Article,,卷期:2012年416-4]
- Domain swapping is a mechanism for forming protein dimers and oligomers with high specificity. It is distinct from other forms of oligomerization in that the binding interface is formed by reciprocal exchange of polypept...
- Arginine Changes the Conformation of the Arginine Attenuator Peptide Relative to the Ribosome Tunnel
[作者:Wu, C; Wei, JJ; Lin, PJ; Tu, LW; Deutsch, C; Johnson, AE; Sachs, MS,期刊:Journal of Molecular Biology, 页码:518-533 , 文章类型: Article,,卷期:2012年416-4]
- The fungal arginine attenuator peptide (AAP) is a regulatory peptide that controls ribosome function. As a nascent peptide within the ribosome exit tunnel, it acts to stall ribosomes in response to arginine (Arg). We use...
- From Dusk till Dawn: One-Plasmid Systems for Light-Regulated Gene Expression
[作者:Ohlendorf, R; Vidavski, RR; Eldar, A; Moffat, K; Moglich, A,期刊:Journal of Molecular Biology, 页码:534-542 , 文章类型: Article,,卷期:2012年416-4]
- Signaling photoreceptors mediate diverse organismal adaptations in response to light. As light-gated protein switches, signaling photoreceptors provide the basis for optogenetics, a term that refers to the control of org...
- Complex Spatial Organization and Flagellin Composition of Flagellar Propeller from Marine Magnetotactic Ovoid Strain MO-1
[作者:Zhang, WJ; Santini, CL; Bernadac, A; Ruan, JF; Zhang, SD; Kato, T; Li, Y; Namba, K; Wu, LF,期刊:Journal of Molecular Biology, 页码:558-570 , 文章类型: Article,,卷期:2012年416-4]
- Marine magnetotactic ovoid bacterium MO-1 is capable of swimming along the geomagnetic field lines by means of its two sheathed flagellar bundles at a speed up to 300 mu m/s. In this study, by using electron microscopy, ...
- Modifications Modulate Anticodon Loop Dynamics and Codon Recognition of E. coil tRNA (Arg1,2)
[作者:Cantara, WA; Bilbille, Y; Kim, J; Kaiser, R; Leszczynska, G; Malkiewicz, A; Agris, PF,期刊:Journal of Molecular Biology, 页码:579-597 , 文章类型: Article,,卷期:2012年416-4]
- Three of six arginine codons are read by two tRNA(Arg) isoacceptors in Escherichia coli. The anticodon stem and loop of these isoacceptors (ASL(Arg1,2)) differs only in that the position 32 cytidine of tRNA(Arg1) is post...
- Fibrillization Propensity for Short Designed Hexapeptides Predicted by Computer Simulation
[作者:Wagoner, VA; Cheon, M; Chang, I; Hall, CK,期刊:Journal of Molecular Biology, 页码:598-609 , 文章类型: Article,,卷期:2012年416-4]
- Assembly of normally soluble proteins into ordered aggregates, known as amyloid fibrils, is a cause or associated symptom of numerous human disorders, including Alzheimer's and the prion diseases. Here, we test the abili...
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