- Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation
[作者：Hegde, S; Ni, S; He, S; Yoon, D; Feng, GS; Watowich, SS; Paulson, RF; Hankey, PA,期刊：Oncogene, 页码：3349-3359 , 文章类型： Article，,卷期：2009年28-38]
- Leukemogenesis requires two classes of mutations, one that promotes proliferation and one that blocks differentiation. The erythroleukemia induced by Friend virus is a multi-stage disease characterized by an early prolif...
- MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation
[作者：Lee, KH; Chen, YL; Yeh, SD; Hsiao, M; Lin, JT; Goan, YG; Lu, PJ,期刊：Oncogene, 页码：3360-3370 , 文章类型： Article，,卷期：2009年28-38]
- MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of human cancer c...
- Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancers
[作者：Ebi, H; Sato, T; Sugito, N; Hosono, Y; Yatabe, Y; Matsuyama, Y; Yamaguchi, T; Osada, H; Suzuki, M; Takahashi, T,期刊：Oncogene, 页码：3371-3379 , 文章类型： Article，,卷期：2009年28-38]
- Small-cell lung cancer (SCLC) is a highly aggressive disease that exhibits rapid growth and genetic instability. We found earlier frequent overexpression of the miR-17-92 microRNA cluster, and showed that SCLC cells were...
- p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1
[作者：Cherrier, T; Suzanne, S; Redel, L; Calao, M; Marban, C; Samah, B; Mukerjee, R; Schwartz, C; Gras, G; Sawaya, BE; Zeichner, SL; Aunis, D; Van Lint, C; Rohr, O,期刊：Oncogene, 页码：3380-3389 , 文章类型： Article，,卷期：2009年28-38]
- Mainly regulated at the transcriptional level, the cellular cyclin-dependent kinase inhibitor, CDKN1A/p21(WAF1) (p21), is a major cell cycle regulator of the response to DNA damage, senescence and tumor suppression. Here...
- Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling
[作者：Palamakumbura, AH; Vora, SR; Nugent, MA; Kirsch, KH; Sonenshein, GE; Trackman, PC,期刊：Oncogene, 页码：3390-3400 , 文章类型： Article，,卷期：2009年28-38]
- Enhanced RAS signaling and decreased androgen dependence of prostate cancer cells accompany poor clinical outcomes. Elevated autocrine fibroblast growth factors 2 (FGF-2) signaling promotes prostate cancer cell growth an...
- Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin
[作者：Wan, X; Kim, SY; Guenther, LM; Mendoza, A; Briggs, J; Yeung, C; Currier, D; Zhang, H; Mackall, C; Li, WJ; Tuan, RS; Deyrup, AT; Khanna, C; Helman, L,期刊：Oncogene, 页码：3401-3411 , 文章类型： Article，,卷期：2009年28-38]
- The development of pulmonary metastasis is the major cause of death in osteosarcoma, and its molecular basis is poorly understood. In this study, we show that beta 4 integrin is highly expressed in human osteosarcoma cel...
- Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells
[作者：Dai, J; Peng, L; Fan, K; Wang, H; Wei, R; Ji, G; Cai, J; Lu, B; Li, B; Zhang, D; Kang, Y; Tan, M; Qian, W; Guo, Y,期刊：Oncogene, 页码：3412-3422 , 文章类型： Article，,卷期：2009年28-38]
- Angiogenesis is a key step in tumor growth and metastasis. The mechanism by which osteopontin (OPN) induces the angiogenesis of endothelial cells remains unclear. Here, we show that OPN confers cytoprotection through the...
- Histone macroH2A isoforms predict the risk of lung cancer recurrence
[作者：Sporn, JC; Kustatscher, G; Hothorn, T; Collado, M; Serrano, M; Muley, T; Schnabel, P; Ladurner, AG,期刊：Oncogene, 页码：3423-3428 , 文章类型： Article，,卷期：2009年28-38]
- Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumor recurrenc...
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