- Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
[作者：Coulouarn, C; Factor, VM; Andersen, JB; Durkin, ME; Thorgeirsson, SS,期刊：Oncogene, 页码：3526-3536 , 文章类型： Article，,卷期：2009年28-40]
- Growing evidence indicates that microRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis. In this study, we evaluated the clinical and functional rele...
- Autocrine semaphorin 3A signaling promotes glioblastoma dispersal
[作者：Bagci, T; Wu, JK; Pfannl, R; Ilag, LL; Jay, DG,期刊：Oncogene, 页码：3537-3550 , 文章类型： Article，,卷期：2009年28-40]
- Glioblastoma multiforme (GBM) is the most malignant glioma type with diffuse borders due to extensive tumor cell infiltration. Therefore, understanding the mechanism of GBM cell dispersal is critical for developing effec...
- Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules
[作者：Mielgo, A; Torres, VA; Clair, K; Barbero, S; Stupack, DG,期刊：Oncogene, 页码：3551-3562 , 文章类型： Article，,卷期：2009年28-40]
- Microtubule-perturbing drugs have become front-line chemotherapeutics, inducing cell-cycle crisis as a major mechanism of action. However, these agents show pleiotropic effects on cells and can induce apoptosis through o...
- Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax
[作者：Yamagata, H; Shimizu, S; Nishida, Y; Watanabe, Y; Craigen, WJ; Tsujimoto, Y,期刊：Oncogene, 页码：3563-3572 , 文章类型： Article，,卷期：2009年28-40]
- Mitochondrial membrane permeabilization is central to apoptotic signaling and is directly regulated by the Bcl-2 family of proteins, consisting of anti-apoptotic members and pro-apoptotic members, although the precise me...
- Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction
[作者：Baritaki, S; Chapman, A; Yeung, K; Spandidos, DA; Palladino, M; Bonavida, B,期刊：Oncogene, 页码：3573-3585 , 文章类型： Article，,卷期：2009年28-40]
- Metastasis is associated with the loss of epithelial features and the acquisition of mesenchymal characteristics and invasive properties by tumor cells, a process known as epithelial to mesenchymal transition (EMT). Snai...
- The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair
[作者：Westhoff, MA; Kandenwein, JA; Karl, S; Vellanki, SHK; Braun, V; Eramo, A; Antoniadis, G; Debatin, KM; Fulda, S,期刊：Oncogene, 页码：3586-3596 , 文章类型： Article，,卷期：2009年28-40]
- The failure of conventional therapies in glioblastoma (GBM) is largely due to an aberrant activity of survival cascades, such as PI3 kinase (PI3K)/Akt-mediated signaling. This study is the first to show that the class I ...
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