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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT [作者：Lafferty-Whyte, K; Cairney, CJ; Will, MB; Serakinci, N; Daidone, MG; Zaffaroni, N; Bilsland, A; Keith, WN,期刊：Oncogene, 页码：3765-3774 , 文章类型： Article，,卷期：2009年28-43] Telomere length is maintained by two known mechanisms, the activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and it is unk... Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage [作者：Yuan, BZ; Chapman, J; Reynolds, SH,期刊：Oncogene, 页码：3775-3786 , 文章类型： Article，,卷期：2009年28-43] Proteasome inhibitors (PIs) are promising new therapeutic agents for treating non-small cell lung carcinoma (NSCLC). To investigate the mechanisms of action of PIs, we analyzed the proapoptotic activities of PIs (MG132 o... Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors [作者：Fazi, B; Melino, S; De Rubeis, S; Bagni, C; Paci, M; Piacentini, M; Di Sano, F,期刊：Oncogene, 页码：3814-3824 , 文章类型： Article，,卷期：2009年28-43] Reticulons are a family of highly conserved proteins, localized in the endoplasmic reticulum (ER) and involved in different cellular functions, such as intracellular membrane trafficking, apoptosis and nuclear envelope f... NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association [作者：Chan, CB; Liu, X; Jang, SW; Hsu, SIH; Williams, I; Kang, S; Chen, J; Ye, K,期刊：Oncogene, 页码：3825-3836 , 文章类型： Article，,卷期：2009年28-43] Cyclin A1 is essential for leukemia progression, and its expression is tightly regulated by acinus, a nuclear speckle protein. However, the molecular mechanism of how acinus mediates cyclin A1 expression remains elusive.... Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity [作者：Switzer, CH; Ridnour, LA; Cheng, RYS; Sparatore, A; Del Soldato, P; Moody, TW; Vitek, MP; Roberts, DD; Wink, DA,期刊：Oncogene, 页码：3837-3846 , 文章类型： Article，,卷期：2009年28-43] The chemopreventative effects of dithiolethione compounds are attributed to their activation of antioxidant response elements (AREs) by reacting with the Nrf2/Keap1 protein complex. In this study, we show anti-proliferat... A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes [作者：Bohm, M; Locke, WJ; Sutherland, RL; Kench, JG; Henshall, SM,期刊：Oncogene, 页码：3847-3856 , 文章类型： Article，,卷期：2009年28-43] GATA-2, a member of the GATA family of transcription factors, is involved in androgen receptor (AR) signaling, however, little is known regarding its role in prostate cancer. Here, we report that GATA-2 is expressed in a... Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation [作者：Montano, X,期刊：Oncogene, 页码：3787-3800 , 文章类型： Article，,卷期：2009年28-43] The nerve growth factor (NGF) receptor, trkA, the tumour suppressor p53 and the phosphatase SHP-1 are critical in cell proliferation and differentiation. SHP-1 is a trkA phosphatase that dephosphorylates trkA at tyrosine... Nuclear EGFR contributes to acquired resistance to cetuximab [作者：Li, C; Iida, M; Dunn, EF; Ghia, AJ; Wheeler, DL,期刊：Oncogene, 页码：3801-3813 , 文章类型： Article，,卷期：2009年28-43] Epidermal growth factor receptor (EGFR) is a ubiquitously expressed receptor tyrosine kinase involved in the etiology of several human cancers. Cetuximab is an EGFR-blocking antibody that has been approved for the treatm...