- The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene
[作者：Chua, YL; Ito, Y; Pole, JCM; Newman, S; Chin, SF; Stein, RC; Ellis, IO; Caldas, C; O'hare, MJ; Murrell, A; Edwards, PAW,期刊：Oncogene, 页码：4041-4052 , 文章类型： Article，,卷期：2009年28-46]
- Neuregulin-1 (NRG1) is both a candidate oncogene and a candidate tumour suppressor gene. It not only encodes the heregulins and other mitogenic ligands for the ERBB family, but also causes apoptosis in NRG1-expressing ce...
- The DEAD-box protein p72 regulates ER alpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ER alpha-positive breast cancer
[作者：Wortham, NC; Ahamed, E; Nicol, SM; Thomas, RS; Periyasamy, M; Jiang, J; Ochocka, AM; Shousha, S; Huson, L; Bray, SE; Coombes, RC; Ali, S; Fuller-Pace, FV,期刊：Oncogene, 页码：4053-4064 , 文章类型： Article，,卷期：2009年28-46]
- The DEAD-box RNA helicases p68 (DDX5) and p72 (DDX17) have been shown to act as transcriptional co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ER alpha). Here, we show tha...
- Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells
[作者：Song, B; Wang, Y; Xi, Y; Kudo, K; Bruheim, S; Botchkina, GI; Gavin, E; Wan, Y; Formentini, A; Kornmann, M; Fodstad, O; Ju, J,期刊：Oncogene, 页码：4065-4074 , 文章类型： Article，,卷期：2009年28-46]
- In this study, high-throughput microRNA (miRNA) expression analysis revealed that the expression of miR-140 was associated with chemosensitivity in osteosarcoma tumor xenografts. Tumor cells ectopically transfected with ...
- Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin
[作者：Gao, SB; Feng, ZJ; Xu, B; Wu, Y; Yin, P; Yang, Y; Hua, X; Jin, GH,期刊：Oncogene, 页码：4095-4104 , 文章类型： Article，,卷期：2009年28-46]
- Menin upregulates transcription of cell-cycle inhibitors to suppress endocrine tumors, but it is poorly understood how menin suppresses non-endocrine tumors such as lung cancer. Here, we show that menin inhibits prolifer...
- p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1 alpha-directed migration in chronic myeloid leukemia cells
[作者：Chang, YC; Tien, SC; Tien, HF; Zhang, H; Bokoch, GM; Chang, ZF,期刊：Oncogene, 页码：4105-4115 , 文章类型： Article，,卷期：2009年28-46]
- Chronic myeloid leukemia (CML) is a lethal hematological disorder caused by the p210(Bcr-Abl) oncogene. Previous studies have suggested that p210(Bcr-Abl) transformation contributes to homing and retention defects, typic...
- PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL
[作者：Ueno, S; Tatetsu, H; Hata, H; Iino, T; Niiro, H; Akashi, K; Tenen, DG; Mitsuya, H; Okuno, Y,期刊：Oncogene, 页码：4116-4125 , 文章类型： Article，,卷期：2009年28-46]
- We earlier reported that PU.1 was downregulated in myeloma cell lines and myeloma cells in a subset of myeloma patients, and that conditional PU.1 expression in PU.1-negative myeloma cell lines, U266 and KMS12PE, induced...
- GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance
[作者：Luo, W; Gangwal, K; Sankar, S; Boucher, KM; Thomas, D; Lessnick, SL,期刊：Oncogene, 页码：4126-4132 , 文章类型： Article，,卷期：2009年28-46]
- Ewing's sarcoma is a malignant bone-associated tumor of children and young adults. Most cases of Ewing's sarcoma express the EWS/FLI fusion protein. EWS/FLI functions as an aberrant ETS-type transcription factor and serv...
- The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells
[作者：Farina, AR; Tacconelli, A; Cappabianca, L; Cea, G; Chioda, A; Romanelli, A; Pensato, S; Pedone, C; Gulino, A; Mackay, AR,期刊：Oncogene, 页码：4075-4094 , 文章类型： Article，,卷期：2009年28-46]
- Hsp90 chaperones stabilize many tyrosine kinases including several oncogenes, which are inhibited or induced to degrade by the Hsp90 inhibitor geldanamycin (GA). As a consequence, GA has been developed for future chemoth...
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