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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer [作者：Najdi, R; Syed, A; Arce, L; Theisen, H; Ting, JHT; Atcha, F; Nguyen, AV; Martinez, M; Holcombe, RF; Edwards, RA; Marsh, JL; Waterman, ML,期刊：Oncogene, 页码：4133-4146 , 文章类型： Article，,卷期：2009年28-47] Constitutive activation of the Wnt/beta-catenin pathway has been implicated as the primary cause of colon cancer. However, the major transducers of Wnt signaling in the intestine, T-cell factor 1 (TCF-1) and TCF-4, have ... 'Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma' [作者：Orgaz, JL; Ladhani, O; Hoek, KS; Fernandez-Barral, A; Mihic, D; Aguilera, O; Seftor, EA; Bernad, A; Rodriguez-Peralto, JL; Hendrix, MJC; Volpert, OV; Jimenez, B,期刊：Oncogene, 页码：4147-4161 , 文章类型： Article，,卷期：2009年28-47] Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein that displays broad antitumor activity based on dual targeting of the tumor microenvironment (anti-angiogenic action) and the tumor cell... Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire [作者：Chan, IH; Privalsky, ML,期刊：Oncogene, 页码：4162-4174 , 文章类型： Article，,卷期：2009年28-47] Thyroid hormone receptors (TRs) are hormone-regulated transcription factors that control multiple aspects of normal physiology and development. Mutations in TRs have been identified at high frequency in certain cancers, ... The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics [作者：Vlachos, P; Joseph, B,期刊：Oncogene, 页码：4175-4188 , 文章类型： Article，,卷期：2009年28-47] The cyclin-dependent kinase inhibitor p57(Kip2) gene has been suggested to be a tumor suppressor gene, being inactivated in various cancer types, linked to tumor progression and poor patient outcome. Here, we report that... LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer [作者：Ong, DCT; Ho, YM; Rudduck, C; Chin, K; Kuo, WL; Lie, DKH; Chua, CLM; Tan, PH; Eu, KW; Seow-Choen, F; Wong, CY; Hong, GS; Gray, JW; Lee, ASG,期刊：Oncogene, 页码：4189-4200 , 文章类型： Article，,卷期：2009年28-47] Deletion of 11q23-q24 is frequent in a diverse variety of malignancies, including breast and colorectal carcinoma, implicating the presence of a tumor suppressor gene at that chromosomal region. We examined a 6-Mb region... RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells [作者：Jian, Y; Gao, Z; Sun, J; Shen, Q; Feng, F; Jing, Y; Yang, C,期刊：Oncogene, 页码：4201-4211 , 文章类型： Article，,卷期：2009年28-47] Nucleophosmin (NPM) is a multifunctional protein involved in both proliferation and apoptosis. Importantly, NPM negatively regulates p53 and is frequently overexpressed in a wide variety of cancers. To identify inhibitor... Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation [作者：Jacinto, FV; Ballestar, E; Esteller, M,期刊：Oncogene, 页码：4212-4224 , 文章类型： Article，,卷期：2009年28-47] Understanding the mechanisms that link changes in DNA methylation with histone modifications is particularly relevant in the case of tumor suppressor genes that undergo transcriptional silencing in cancer cells in associ...