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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene [作者：Jaskelioff, M; Song, W; Xia, J; Liu, C; Kramer, J; Koido, S; Gendler, SJ; Calderwood, SK; Gong, J,期刊：Oncogene, 页码：4225-4236 , 文章类型： Article，,卷期：2009年28-48] Mice transgenic for MUC1 (mucin 1) and polyomavirus middle T (PyMT) develop mammary carcinomas within 15 weeks with 100% penetrance. PyMT-induced mammary tumorigenesis is closely correlated with robust telomerase express... A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis [作者：Blackburn, JS; Liu, I; Coon, CI; Brinckerhoff, CE,期刊：Oncogene, 页码：4237-4248 , 文章类型： Article，,卷期：2009年28-48] Hallmarks of malignant melanoma are its propensity to metastasize and its resistance to treatment, giving patients with advanced disease a poor prognosis. The transition of melanoma from non-invasive radial growth phase ... PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis [作者：Gu, JJ; Wang, Z; Reeves, R; Magnuson, NS,期刊：Oncogene, 页码：4261-4271 , 文章类型： Article，,卷期：2009年28-48] The serine/threonine kinase, PIM1, is involved in promoting cell survival in part by phosphorylation and inhibition of proapoptotic proteins. Apoptosis signaling kinase 1 (ASK1), a mitogen-activated protein kinase kinase... Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration [作者：Li, X; Shen, Y; Ichikawa, H; Antes, T; Goldberg, GS,期刊：Oncogene, 页码：4272-4283 , 文章类型： Article，,卷期：2009年28-48] Transformation by the Src tyrosine kinase (Src) promotes nonanchored cell growth and migration. However, non-transformed cells can force Src-transformed cells to assume a normal morphology and phenotype by a process call... Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions [作者：Walerych, D; Olszewski, MB; Gutkowska, M; Helwak, A; Zylicz, M; Zylicz, A,期刊：Oncogene, 页码：4284-4294 , 文章类型： Article，,卷期：2009年28-48] p53 as an unstable protein in vitro likely requires stabilizing factors to act as a tumor suppressor in vivo. Here, we show that in human cells transfected with wildtype (WT) p53, Hsp90 and Hsp70 molecular chaperones mai... Pro-proliferative FoxM1 is a target of p53-mediated repression [作者：Barsotti, AM; Prives, C,期刊：Oncogene, 页码：4295-4305 , 文章类型： Article，,卷期：2009年28-48] The p53 tumor suppressor protein acts as a transcription factor to modulate cellular responses to a wide variety of stresses. In this study we show that p53 is required for the downregulation of FoxM1, an essential trans... Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner [作者：di Martino, E; L'Hote, CG; Kennedy, W; Tomlinson, DC; Knowles, MA,期刊：Oncogene, 页码：4306-4316 , 文章类型： Article，,卷期：2009年28-48] Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in bladder tumors, little information is available on their specific effects in urothelial cells or the basis for the observed mut... Synergistic proapoptotic effects of the two tyrosine kinase inhibitors pazopanib and lapatinib on multiple carcinoma cell lines [作者：Olaussen, KA; Commo, F; Tailler, M; Lacroix, L; Vitale, I; Raza, SQ; Richon, C; Dessen, P; Lazar, V; Soria, JC; Kroemer, G,期刊：Oncogene, 页码：4249-4260 , 文章类型： Article，,卷期：2009年28-48] Pazopanib and lapatinib are two tyrosine kinase inhibitors that have been designed to inhibit the VEGF tyrosine kinase receptors 1, 2 and 3 (pazopanib), and the HER1 and HER2 receptors in a dual manner (lapatinib). Pazop...