- Transgenic Overexpression of Anks6((p R823W)) Causes Polycystic Kidney Disease in Rats
[作者：Neudecker, S; Walz, R; Menon, K; Maier, E; Bihoreau, MT; Obermuller, N; Kranzlin, B; Gretz, N; Hoffmann, SC,期刊：American Journal of Pathology, 页码：3000-3009 , 文章类型： Article，,卷期：2010年177-6]
- The PKD/Mhm(cy/+) rat is a widely used animal model for the study of human autosomal dominant polycystic kidney disease one of the most common genetic disorders affecting one in 1000 individuals We identified a new gene ...
- Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis
[作者：de Launay, D; Vreijling, J; Hartkamp, LM; Karpus, ON; Abreu, JRF; van Maanen, MA; Sanders, ME; Grabiec, AM; Hamann, J; Orum, H; Vervoordeldonk, MJ; Fluiter, K; Tak, PP; Reedquist, KA,期刊：American Journal of Pathology, 页码：3010-3024 , 文章类型： Article，,卷期：2010年177-6]
- Changes in the expression and activation status of Ras proteins are thought to contribute to the pathological phenotype of stromal fibroblast like synoviocytes (FLS) m rheumatoid arthritis a prototypical immune mediated ...
- Colorectal Cancer Susceptibility Loci in a Population-Based Study Associations with Morphological Parameters
[作者：Ghazi, S; von Holst, S; Picelli, S; Lindforss, U; Tenesa, A; Famngton, SM; Campbell, H; Dunlop, MG; Papadogiannakis, N; Lindblom, A,期刊：American Journal of Pathology, 页码：2688-2693 , 文章类型： Article，,卷期：2010年177-6]
- Recent genome wide association studies have identified multiple genetic loci and single nucleotide polymorphisms (SNPs) associated with either increased or de creased risk of colorectal cancer (CRC) In the present study ...
- Pilocytic Astrocytomas Have Telomere-Associated Promyelocytic Leukemia Bodies without Alternatively Lengthened Telomeres
[作者：Slatter, T; Garner, JG; Wiles, A; Tan, X; Chen, YJ; MacFarlane, M; Sullivan, M; Royds, J; Hung, N,期刊：American Journal of Pathology, 页码：2694-2700 , 文章类型： Article，,卷期：2010年177-6]
- Telomere maintenance by either telomerase activity or the recombination mediated alternative lengthening of telomeres (ALT) mechanism is a hallmark of cancer Tumors that use ALT as their telomere maintenance mechanism ar...
- Mutant (CCTG)n Expansion Causes Abnormal Expression of Zinc Finger Protein 9 (ZNF9) in Myotonic Dystrophy Type 2
[作者：Raheem, O; Olufemi, SE; Bachinski, LL; Vihola, A; Sirito, M; Hampf, JH; Haapasalo, H; Li, YP; Udd, B; Krahe, R,期刊：American Journal of Pathology, 页码：3025-3036 , 文章类型： Article，,卷期：2010年177-6]
- The mutation that underlies myotonic dystrophy type 2 (DM2) is a (CCTG)n expansion in intron 1 of zinc finger protein 9 (ZNF9) It has been suggested that ZNF9 is of no consequence for disease pathogenesis We determined t...
- Abnormal Neurites Containing C-Terminally Truncated alpha-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology
[作者：Lewis, KA; Su, Y; Jou, O; Ritchie, C; Foong, C; Hynan, LS; White, CL; Thomas, PJ; Hatanpaa, KJ,期刊：American Journal of Pathology, 页码：3037-3050 , 文章类型： Article，,卷期：2010年177-6]
- The pathological hallmark of Parkinson s disease and diffuse Lewy body disease (DLBD) is the aggregation of alpha synuclein (alpha syn) in the form of Lewy bodies and Lewy neurnes Patients with both Alzheimer s disease (...
- Dopamine, by Acting through Its D-2 Receptor, Inhibits Insulin-Like Growth Factor-I (IGF-I)-Induced Gastric Cancer Cell Proliferation via Up-Regulation of Kruppel-Like Factor 4 through Down-Regulation of IGF-IR and AKT Phosphorylation
[作者：Ganguly, S; Basu, B; Shome, S; Jadhav, T; Roy, S; Majumdar, J; Dasgupta, PS; Basu, S,期刊：American Journal of Pathology, 页码：2701-2707 , 文章类型： Article，,卷期：2010年177-6]
- The overexpression of insulin like growth factor receptor I (IGF IR) and the activation of its signaling pathways both play critical roles in the development and progression of gastric cancer Dopamine (DA) a major enteri...
- Molecular Classification of Low-Grade Diffuse Gliomas
[作者：Kim, YH; Nobusawa, S; Mittelbronn, M; Paulus, W; Brokinkel, B; Keyvani, K; Sure, U; Wrede, K; Nakazato, Y; Tanaka, Y; Vital, A; Mariani, L; Stawski, R; Watanabe, T; De Girolami, U; Kleihues, P; Ohgaki, H,期刊：American Journal of Pathology, 页码：2708-2714 , 文章类型： Article，,卷期：2010年177-6]
- The current World Health Organization classification recognizes three histological types of grade H low grade diffuse glioma (diffuse astrocytoma oligoastrocytoma and oligodendroglioma) However the diagnostic criteria m ...
- Glatiramer Acetate Attenuates Pro-Inflammatory T Cell Responses but Does Not Directly Protect Neurons from Inflammatory Cell Death
[作者：Herrmann, AM; Gobel, K; Simon, OJ; Melzer, N; Schuhmann, MK; Stenner, MP; Weishaupt, A; Kleinschnitz, C; Bittner, S; Meuth, P; Stuve, O; Budde, T; Kieseier, BC; Wiendl, H; Meuth, SG,期刊：American Journal of Pathology, 页码：3051-3060 , 文章类型： Article，,卷期：2010年177-6]
- Glatiramer acetate (GA) is a synthetic random basic copolymer capable of modulating adaptive T cell responses In animal models of various inflammatory and degenerative central nervous system disorders GA induced T cells ...
- The Alternative and Terminal Pathways of Complement Mediate Post-Traumatic Spinal Cord Inflammation and Injury
[作者：Qiao, F; Atkinson, C; Kindy, MS; Shunmugavel, A; Morgan, BP; Song, HB; Tomlinson, S,期刊：American Journal of Pathology, 页码：3061-3070 , 文章类型： Article，,卷期：2010年177-6]
- Complement is implicated in the inflammatory response and the secondary neuronal damage that occurs after traumatic spinal cord injury (SCI) Complement can be activated by the classical lectin or alternative pathways all...
- Postnatal Weight Gain Modifies Severity and Functional Outcome of Oxygen-Induced Proliferative Retinopathy
[作者：Stahl, A; Chen, J; Sapieha, P; Seaward, MR; Krah, NM; Dennison, RJ; Favazza, T; Bucher, F; Lofqvist, C; Ong, H; Hellstrom, A; Chemtob, S; Akula, JD; Smith, LEH,期刊：American Journal of Pathology, 页码：2715-2723 , 文章类型： Article，,卷期：2010年177-6]
- In clinical studies postnatal weight gain is strongly associated with retinopathy of prematurity (ROP) However animal studies are needed to investigate the pathophysiological mechanisms of how postnatal weight gain affec...
- Autoimmunity to Desmocollin 3 in Pemphigus Vulgaris
[作者：Mao, XM; Nagler, AR; Farber, SA; Choi, EJ; Jackson, LH; Leiferman, KM; Ishii, N; Hashimoto, T; Amagai, M; Zone, JJ; Payne, AS,期刊：American Journal of Pathology, 页码：2724-2730 , 文章类型： Article，,卷期：2010年177-6]
- Pemphigus vulgaris is a blistering disease associated with autoantibodies to the desmosomal adhesion protein desmoglein 3 Genetic deficiency of desmoglein 3 in mice mimics autoimmunity to desmoglein 3 in pemphigus vulgar...
- Transgenic Mice Overexpressing APP and Transforming Growth Factor-beta 1 Feature Cognitive and Vascular Hallmarks of Alzheimer's Disease
[作者：Ongali, B; Nicolakakis, N; Lecrux, C; Aboulkassim, T; Neto, PR; Papadopoulos, P; Tong, XK; Hamel, E,期刊：American Journal of Pathology, 页码：3071-3080 , 文章类型： Article，,卷期：2010年177-6]
- High brain levels of amyloid beta (A beta) and transforming growth factor beta 1 (TGF beta 1) have been implicated in the cognitive and cerebrovascular alterations of Alzheimer s disease (AD) We sought to investigate the...
- Tumorigenic Potential of Mononucleated Small Cells of Hodgkin Lymphoma Cell Lines
[作者：Ikeda, JI; Mamat, S; Tian, TA; Wang, Y; Rahadiani, N; Aozasa, K; Morii, E,期刊：American Journal of Pathology, 页码：3081-3088 , 文章类型： Article，,卷期：2010年177-6]
- Tumor cells with tumorigenic potential are limited to a small cell population known as cancer stem cells (CSCs) CSCs yield both CSCs and non CSCs whereas non CSCs do not yield CSCs CSCs have not been identified m any mal...
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