- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
[作者：Levental, KR; Yu, HM; Kass, L; Lakins, JN; Egeblad, M; Erler, JT; Fong, SFT; Csiszar, K; Giaccia, A; Weninger, W; Yamauchi, M; Gasser, DL; Weaver, VM,期刊：Cell, 页码：891-906 , 文章类型： Article，,卷期：2009年139-5]
- Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found that breast tumorigenesis i...
- Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis
[作者：Sato, A; Isaac, B; Phillips, CM; Rillo, R; Carlton, PM; Wynne, DJ; Kasad, RA; Dernburg, AF,期刊：Cell, 页码：907-919 , 文章类型： Article，,卷期：2009年139-5]
- During meiosis, each chromosome must pair with its unique homologous partner, a process that usually culminates with the formation of the synaptonemal complex (SC). In the nematode Caenorhabditis elegans, special regions...
- Meiotic Chromosome Homology Search Involves Modifications of the Nuclear Envelope Protein Matefin/SUN-1
[作者：Penkner, AM; Fridkin, A; Gloggnitzer, J; Baudrimont, A; Machacek, T; Woglar, A; Csaszar, E; Pasierbek, P; Ammerer, G; Gruenbaum, Y; Jantsch, V,期刊：Cell, 页码：920-933 , 文章类型： Article，,卷期：2009年139-5]
- Genome haploidization during meiosis depends on recognition and association of parental homologous chromosomes. The C. elegans SUN/KASH domain proteins Matefin/SUN-1 and ZYG-12 have a conserved role in this process. They...
- TFB2 Is a Transient Component of the Catalytic Site of the Human Mitochondrial RNA Polymerase
[作者：Sologub, M; Litonin, D; Anikin, M; Mustaev, A; Temiakov, D,期刊：Cell, 页码：934-944 , 文章类型： Article，,卷期：2009年139-5]
- Transcription in human mitochondria is carried out by a single-subunit, T7-like RNA polymerase assisted by several auxiliary factors. We demonstrate that an essential initiation factor, TFB2, forms a network of interacti...
- RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
[作者：Hale, CR; Zhao, P; Olson, S; Duff, MO; Graveley, BR; Wells, L; Terns, RM; Terns, MP,期刊：Cell, 页码：945-956 , 文章类型： Article，,卷期：2009年139-5]
- Compelling evidence indicates that the CRISPR-Cas system protects prokaryotes from viruses and other potential genome invaders. This adaptive prokaryotic immune system arises from the clustered regularly interspaced shor...
- Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates
[作者：Kleiger, G; Saha, A; Lewis, S; Kuhlman, B; Deshaies, RJ,期刊：Cell, 页码：957-968 , 文章类型： Article，,卷期：2009年139-5]
- Degradation by the ubiquitin-proteasome system requires assembly of a polyubiquitin chain upon substrate. However, the structural and mechanistic features that enable template-independent processive chain synthesis are u...
- Neuronal Subtype Specification within a Lineage by Opposing Temporal Feed-Forward Loops
[作者：Baumgardt, M; Karlsson, D; Terriente, J; Diaz-Benjumea, FJ; Thor, S,期刊：Cell, 页码：969-982 , 文章类型： Article，,卷期：2009年139-5]
- Neural progenitors generate distinct cell types at different stages, but the mechanisms controlling these temporal transitions are poorly understood. In the Drosophila CNS, a cascade of transcription factors, the "tempor...
- RNF12 Is an X-Encoded Dose-Dependent Activator of X Chromosome Inactivation
[作者：Jonkers, I; Barakat, TS; Achame, EM; Monkhorst, K; Kenter, A; Rentmeester, E; Grosveld, F; Grootegoed, JA; Gribnau, J,期刊：Cell, 页码：999-1011 , 文章类型： Article，,卷期：2009年139-5]
- In somatic cells of female placental mammals, one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes. Random X chromosome inactivation (XCI) in the embryo is a stochastic process, i...
- The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior
[作者：Ziemann, AE; Allen, JE; Dahdaleh, NS; Drebot, II; Coryell, MW; Wunsch, AM; Lynch, CM; Faraci, FM; Howard, MA; Welsh, MJ; Wemmie, JA,期刊：Cell, 页码：1012-1021 , 文章类型： Article，,卷期：2009年139-5]
- The amygdala processes and directs inputs and outputs that are key to fear behavior. However, whether it directly senses fear-evoking stimuli is unknown. Because the amygdala expresses acid-sensing ion channel-1a (ASIC1a...
|