- Little Effect of the tan Locus on Pigmentation in Female Hybrids between Drosophila santomea and D. melanogaster
[作者：Matute, DR; Butler, IA; Coyne, JA,期刊：Cell, 页码：1180-1188 , 文章类型： Article，,卷期：2009年139-6]
- Previous work on Drosophila santomea suggested that its absence of abdominal pigmentation, compared to the other darkly pigmented species, is based on mutations in the cis-regulatory region of tan, inactivating the expre...
- Evolution of the tan Locus Contributed to Pigment Loss in Drosophila santomea: A Response to Matute et al.
[作者：Rebeiz, M; Ramos-Womack, M; Jeong, S; Andolfatto, P; Werner, T; True, J; Stern, DL; Carroll, SB,期刊：Cell, 页码：1189-1196 , 文章类型： Article，,卷期：2009年139-6]
- We have shown previously that the loss of abdominal pigmentation in D. santomea relative to its sister species D. yakuba resulted, in part, from cis-regulatory mutations at the tan locus. Matute et al. claim, based solel...
- Switching on Epigenetic Therapy
[作者：Karberg, S,期刊：Cell, 页码：1029-1031 , 文章类型： Editorial Material，,卷期：2009年139-6]
- Reversible epigenetic changes that alter gene expression are a characteristic of many cancers and other diseases. Biotech companies are taking note and are starting to develop new drugs to reverse such pathogenic "epimut...
- iPS Cells: Mapping the Policy Issues
[作者：Zarzeczny, A; Scott, C; Hyun, I; Bennett, J; Chandler, J; Charge, S; Heine, H; Isasi, R; Kato, K; Lovell-Badge, R; McNagny, K; Pei, DQ; Rossant, J; Surani, A; Taylor, PL; Ogbogu, U; Caulfield, T,期刊：Cell, 页码：1032-1037 , 文章类型： Editorial Material，,卷期：2009年139-6]
- Given the explosion of research on induced pluripotent stem (iPS) cells, it is timely to consider the various ethical, legal, and social issues engaged by this fast-moving field. Here, we review issues associated with th...
- The Ends Have Arrived
[作者：Zakian, VA,期刊：Cell, 页码：1038-1040 , 文章类型： Editorial Material，,卷期：2009年139-6]
- The 2009 Nobel Prize in Physiology or Medicine has been awarded to Elizabeth Blackburn, Carol Greider, and Jack Szostak for their contributions to our understanding of how the ends of eukaryotic chromosomes, telomeres, a...
- The Ribosome at Atomic Resolution
[作者：Williamson, JR,期刊：Cell, 页码：1041-1043 , 文章类型： Editorial Material，,卷期：2009年139-6]
- The 2009 Nobel Prize in Chemistry has been awarded to Venki Ramakrishnan, Tom Steitz, and Ada Yonath for crystallographic studies of the ribosome. The atomic resolution structures of the ribosomal subunits provide an ext...
- The Dangers of Transcription
[作者：Mathas, S; Misteli, T,期刊：Cell, 页码：1047-1049 , 文章类型： Editorial Material，,卷期：2009年139-6]
- Transcription is obviously essential, but even a good thing can be dangerous at times. In this issue, Lin et al. (2009) provide evidence that binding of the transcription machinery may predispose genome regions to breaka...
- During Transitions Proteins Make Fleeting Bonds
[作者：Boehr, DD,期刊：Cell, 页码：1049-1051 , 文章类型： Editorial Material，,卷期：2009年139-6]
- How do proteins efficiently and precisely shift from one conformation to another? Gardino et al. (2009) show that transient hydrogen bonds are critical to the conformational transition of the nitrogen regulatory protein ...
- Females Battle to Suppress Their Inner Male
[作者：Sinclair, A; Smith, C,期刊：Cell, 页码：1051-1053 , 文章类型： Editorial Material，,卷期：2009年139-6]
- Conventional wisdom holds that the ovary and testis are terminally differentiated organs in adult mammals. However, Uhlenhaut et al. (2009) now report that deletion of a single gene, Foxl2, is sufficient to induce transd...
- A Tethering Complex Recruits SNAREs and Grabs Vesicles
[作者：Schmitt, HD; Jahn, R,期刊：Cell, 页码：1053-1055 , 文章类型： Editorial Material，,卷期：2009年139-6]
- Protein tethers can bridge gaps between membranes. Ren et al. (2009) now provide evidence that the yeast Dsl1 complex tethers vesicles to the endoplasmic reticulum (ER) by binding ER SNARE proteins at its base and captur...
- Wnt Signaling and the Polarity of the Primary Body Axis
[作者：Petersen, CP; Reddien, PW,期刊：Cell, 页码：1056-1068 , 文章类型： Review，,卷期：2009年139-6]
- How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (protostomes) suggest tha...
- Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer
[作者：Lin, CR; Yang, LQ; Tanasa, B; Hutt, K; Ju, BG; Ohgi, K; Zhang, J; Rose, DW; Fu, XD; Glass, CK; Rosenfeld, MG,期刊：Cell, 页码：1069-1083 , 文章类型： Article，,卷期：2009年139-6]
- Chromosomal translocations are a hallmark of leukemia/lymphoma and also appear in solid tumors, but the underlying mechanism remains elusive. By establishing a cellular model that mimics the relative frequency of authent...
- The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease ReIE
[作者：Neubauer, C; Gao, YG; Andersen, KR; Dunham, CM; Kelley, AC; Hentschel, J; Gerdes, K; Ramakrishnan, V; Brodersen, DE,期刊：Cell, 页码：1084-1095 , 文章类型： Article，,卷期：2009年139-6]
- Translational control is widely used to adjust gene expression levels. During the stringent response in bacteria, mRNA is degraded on the ribosome by the ribosome-dependent endonuclease, ReIE. The molecular basis for rec...
- Conserved MicroRNA miR-8/miR-200 and Its Target USH/FOG2 Control Growth by Regulating PI3K
[作者：Hyun, S; Lee, JH; Jin, H; Nam, J; Namkoong, B; Lee, G; Chung, J; Kim, VN,期刊：Cell, 页码：1096-1108 , 文章类型： Article，,卷期：2009年139-6]
- How body size is determined is a long-standing question in biology, yet its regulatory mechanisms remain largely unknown. Here, we find that a conserved microRNA miR-8 and its target, USH, regulate body size in Drosophil...
- Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein
[作者：Gardino, AK; Villali, J; Kivenson, A; Lei, M; Liu, CF; Steindel, P; Eisenmesser, EZ; Labeikovsky, W; Wolf-Watz, M; Clarkson, MW; Kern, D,期刊：Cell, 页码：1109-1118 , 文章类型： Article，,卷期：2009年139-6]
- Phosphorylation is a common mechanism for activating proteins within signaling pathways. Yet, the molecular transitions between the inactive and active conformational states are poorly understood. Here we quantitatively ...
- A Structure-Based Mechanism for Vesicle Capture by the Multisubunit Tethering Complex Dsl1
[作者：Ren, Y; Yip, CK; Tripathi, A; Huie, D; Jeffrey, PD; Walz, T; Hughson, FM,期刊：Cell, 页码：1119-1129 , 文章类型： Article，,卷期：2009年139-6]
- Vesicle trafficking requires membrane fusion, mediated by SNARE proteins, and upstream events that probably include "tethering,'' an initial long-range attachment between a vesicle and its target organelle. Among the fac...
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