- CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
[作者：Jaiswal, S; Jamieson, CHM; Pang, WW; Park, CY; Chao, MP; Majeti, R; Traver, D; van Rooijen, N; Weissman, IL,期刊：Cell, 页码：271-285 , 文章类型： Article，,卷期：2009年138-2]
- Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRP alpha, to inhibit phagocytosis of normal, healthy cells. We...
- CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells
[作者：Majeti, R; Chao, MP; Alizadeh, AA; Pang, WW; Jaiswal, S; Gibbs, KD; van Rooijen, N; Weissman, IL,期刊：Cell, 页码：286-299 , 文章类型： Article，,卷期：2009年138-2]
- Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased CD47 expression on human AML LSC contribut...
- MafB Restricts M-CSF-Dependent Myeloid Commitment Divisions of Hematopoietic Stem Cells
[作者：Sarrazin, S; Mossadegh-Keller, N; Fukao, T; Aziz, A; Mourcin, F; Vanhille, L; Modis, LK; Kastner, P; Chan, S; Duprez, E; Otto, C; Sieweke, MH,期刊：Cell, 页码：300-313 , 文章类型： Article，,卷期：2009年138-2]
- While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinct control mechanisms enable HSC divisions that generate progeny cells with specific lineage bias. Here, we report that t...
- A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription Factors
[作者：Grove, CA; De Masi, F; Barrasa, MI; Newburger, DE; Alkema, MJ; Bulyk, ML; Walhout, AJM,期刊：Cell, 页码：314-327 , 文章类型： Article，,卷期：2009年138-2]
- Differences in expression, protein interactions, and DNA binding of paralogous transcription factors ("TF parameters'') are thought to be important determinants of regulatory and biological specificity. However, both the...
- Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation
[作者：Gruber, JJ; Zatechka, DS; Sabin, LR; Yong, J; Lum, JJ; Kong, M; Zong, WX; Zhang, ZX; Lau, CK; Rawlings, J; Cherry, S; Ihle, JN; Dreyfuss, G; Thompson, CB,期刊：Cell, 页码：328-339 , 文章类型： Article，,卷期：2009年138-2]
Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linke...
- Cyclin A Is Redundant in Fibroblasts but Essential in Hematopoietic and Embryonic Stem Cells
[作者：Kalaszczynska, I; Geng, Y; Iino, T; Mizuno, SI; Choi, Y; Kondratiuk, I; Silver, DP; Wolgemuth, DJ; Akashi, K; Sicinski, P,期刊：Cell, 页码：352-365 , 文章类型： Article，,卷期：2009年138-2]
- Cyclins are regulatory subunits of cyclin-dependent kinases. Cyclin A, the first cyclin ever cloned, is thought to be an essential component of the cell-cycle engine. Mammalian cells encode two A-type cyclins, testis-spe...
- An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal
[作者：Honnappa, S; Gouveia, SM; Weisbrich, A; Damberger, FF; Bhavesh, NS; Jawhari, H; Grigoriev, I; van Rijssel, FJA; Buey, RM; Lawera, A; Jelesarov, I; Winkler, FK; Wuthrich, K; Akhmanova, A; Steinmetz, MO,期刊：Cell, 页码：366-376 , 文章类型： Article，,卷期：2009年138-2]
- Microtubules are filamentous polymers essential for cell viability. Microtubule plus-end tracking proteins (+TIPs) associate with growing microtubule plus ends and control microtubule dynamics and interactions with diffe...
- Defining the Human Deubiquitinating Enzyme Interaction Landscape
[作者：Sowa, ME; Bennett, EJ; Gygi, SP; Harper, JW,期刊：Cell, 页码：389-403 , 文章类型： Article，,卷期：2009年138-2]
- Deubiquitinating enzymes (Dubs) function to remove covalently attached ubiquitin from proteins, thereby controlling substrate activity and/or abundance. For most Dubs, their functions, targets, and regulation are poorly ...
- Stressing Out over tRNA Cleavage
[作者：Thompson, DM; Parker, R,期刊：Cell, 页码：215-219 , 文章类型： Editorial Material，,卷期：2009年138-2]
- A conserved response to stress involves endonucleolytic cleavage of cytoplasmic transfer RNAs (tRNAs) by ribonucleases that are normally secreted or sequestered. Ribonuclease activation or release is an intriguing new as...
- Cell Death: A New Par-4 the TRAIL
[作者：Hart, LS; El-Deiry, WS,期刊：Cell, 页码：220-222 , 文章类型： Editorial Material，,卷期：2009年138-2]
- The protein Par-4 acts in the cytoplasm to trigger cell death signaling via caspase activation and the mitochondrial release of cytochrome c. Burikhanov et al. (2009) now provide surprising evidence that Par-4 can also p...
- Navigating the Deubiquitinating Proteome with a CompPASS
[作者：Jackson, PK,期刊：Cell, 页码：222-224 , 文章类型： Editorial Material，,卷期：2009年138-2]
- Deubiquitinating enzymes (DUBs) act on ubiquitinated substrates to regulate their modification and stability. In this issue, Sowa et al. (2009) present a comprehensive proteomic analysis of DUB interacting proteins in hu...
- Ars2 and the Cap-Binding Complex Team up for Silencing
[作者：Nielsen, AF; Gloggnitzer, J; Martinez, J,期刊：Cell, 页码：224-226 , 文章类型： Editorial Material，,卷期：2009年138-2]
- In this issue, Sabin et al. (2009) and Gruber et al. (2009) reveal the protein Ars2 as a versatile regulator of RNA silencing. They show that Ars2 stimulates microRNA processing, contributes to antiviral resistance in fl...
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