- Biotech's Perfect Storm
[作者：Karberg, S,期刊：Cell, 页码：413-415 , 文章类型： Editorial Material，,卷期：2009年138-3]
- The global financial crisis has hit biotech companies hard both in the US and Europe as venture capital dries up. Finding new sources of long-term financing for translating research into new therapeutics will be essentia...
- Learning Tolerance while Fighting Ignorance
[作者：Sansonetti, PJ; Medzhitov, R,期刊：Cell, 页码：416-420 , 文章类型： Article，,卷期：2009年138-3]
- Research on microbe-host interactions focuses principally on pathogens, yet our immune system must deal with the huge number of beneficial commensal bacteria in our gut. It is becoming clear that the host immune system m...
- MicroRNAs and Parallel Stem Cell Lives
[作者：Dirks, PB,期刊：Cell, 页码：423-424 , 文章类型： Editorial Material，,卷期：2009年138-3]
- A new study by Shimono et al. ( 2009) demonstrates that certain microRNAs that regulate the self-renewal factor BMI1 are downregulated in purified populations of normal mammary epithelial stem cells and breast tumor-init...
- Alpha Cells Beget Beta Cells
[作者：Liu, ZY; Habener, JF,期刊：Cell, 页码：424-426 , 文章类型： Editorial Material，,卷期：2009年138-3]
- Understanding the origins of insulin-producing beta cells of the pancreas could lead to new treatments for diabetes. Collombat et al. ( 2009) now show that in response to injury, a population of pancreatic progenitor cel...
- Data Harvesting from fields of spindles
[作者：Gatlin, JC; Salmon, ED,期刊：Cell, 页码：426-428 , 文章类型： Editorial Material，,卷期：2009年138-3]
- The mitotic spindle is essential for chromosome segregation and must be large enough to accommodate all of the chromatin in the dividing cell. In this issue, Dinarina et al. (2009) grow "fields" of spindles on coverslips...
- DNA Makes RNA Makes Innate Immunity
[作者：O'Neill, LAJ,期刊：Cell, 页码：428-430 , 文章类型： Editorial Material，,卷期：2009年138-3]
- Microbial DNA in the cytosol induces production of interferon-beta (IFN-beta) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA relea...
- Time's up: Bursting out of Transcription
[作者：Ford, E; Thanos, D,期刊：Cell, 页码：430-432 , 文章类型： Editorial Material，,卷期：2009年138-3]
- Many inducible genes are transcribed in bursts. In this issue, Degenhardt et al. (2009) report computational models that predict and validate patterns of stochastic gene expression.
- Human Telomerase caught in the Act
[作者：Wu, P; de Lange, T,期刊：Cell, 页码：432-434 , 文章类型： Editorial Material，,卷期：2009年138-3]
- Based on prior work, it was expected that telomerase would preferentially elongate the shortest telomeres in a cell, extending the telomeric G-rich strand through a process that is coupled to the synthesis of the complem...
- The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into alpha and Subsequently beta Cells
[作者：Collombat, P; Xu, XB; Ravassard, P; Sosa-Pineda, B; Dussaud, S; Billestrup, N; Madsen, OD; Serup, P; Heimberg, H; Mansouri, A,期刊：Cell, 页码：449-462 , 文章类型： Article，,卷期：2009年138-3]
- We have previously reported that the loss of Arx and/or Pax4 gene activity leads to a shift in the fate of the different endocrine cell subtypes in the mouse pancreas, without affecting the total endocrine cell numbers. ...
- Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells
[作者：Zhao, Y; Sfeir, AJ; Zou, Y; Buseman, CM; Chow, TT; Shay, JW; Wright, WE,期刊：Cell, 页码：463-475 , 文章类型： Article，,卷期：2009年138-3]
- Telomeres are thought to be maintained by the preferential recruitment of telomerase to the shortest telomeres. The extension of the G-rich telomeric strand by telomerase is also believed to be coordinated with the compl...
- Identification of a Physiologically Relevant Endogenous Ligand for PPAR alpha in Liver
[作者：Chakravarthy, MV; Lodhi, IJ; Yin, L; Malapaka, RRV; Xu, HE; Turk, J; Semenkovich, CF,期刊：Cell, 页码：476-488 , 文章类型： Article，,卷期：2009年138-3]
- The nuclear receptor PPAR alpha is activated by drugs to treat human disorders of lipid metabolism. Its endogenous ligand is unknown. PPAR alpha-dependent gene expression is impaired with inactivation of fatty acid synth...
- Population-Level Transcription Cycles Derive from Stochastic Timing of Single-Cell Transcription
[作者：Degenhardt, T; Rybakova, KN; Tomaszewska, A; Mone, MJ; Westerhoff, HV; Bruggeman, FJ; Carlberg, C,期刊：Cell, 页码：489-501 , 文章类型： Article，,卷期：2009年138-3]
- Eukaryotic transcription is a dynamic process relying on a large number of proteins. By measuring the cycling expression of the pyruvate dehydrogenase kinase 4 gene in human cells, we constructed a detailed stochastic mo...
- Chromatin Shapes the Mitotic Spindle
[作者：Dinarina, A; Pugieux, C; Corral, MM; Loose, M; Spatz, J; Karsenti, E; Nedelec, F,期刊：Cell, 页码：502-513 , 文章类型： Article，,卷期：2009年138-3]
- In animal and plant cells, mitotic chromatin locally generates microtubules that self-organize into a mitotic spindle, and its dimensions and bipolar symmetry are essential for accurate chromosome segregation. By immobil...
- The Selectivity of Receptor Tyrosine Kinase Signaling Is Controlled by a Secondary SH2 Domain Binding Site
[作者：Bae, JH; Lew, ED; Yuzawa, S; Tome, F; Lax, I; Schlessinger, J,期刊：Cell, 页码：514-524 , 文章类型： Article，,卷期：2009年138-3]
- SH2 domain-mediated interactions represent a crucial step in transmembrane signaling by receptor tyrosine kinases. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosp...
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