- Clinical Features of Idiopathic Gastroparesis Vary With Sex, Body Mass, Symptom Onset, Delay in Gastric Emptying, and Gastroparesis Severity
[作者:Parkman, HP; Yates, K; Hasler, WL; Nguyen, L; Pasricha, PJ; Snape, WJ; Farrugia, G; Koch, KL; Abell, TL; McCallum, RW; Lee, L; Unalp-Arida, A; Tonascia, J; Hamilton, F,期刊:Gastroenterology, 页码:101-+ , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the National Institute of Diabetes and D...
- Histomorphometric Analysis Reveals Reduced Bone Mass and Bone Formation in Patients With Quiescent Crohn's Disease
[作者:Oostlander, AE; Bravenboer, N; Sohl, E; Holzmann, PJ; van der Woude, CJ; Dijkstra, G; Stokkers, PCF; Oldenburg, B; Netelenbos, JC; Hommes, DW; van Bodegraven, AA; Lips, P,期刊:Gastroenterology, 页码:116-123 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Crohn's disease (CD) is associated with an increased prevalence of osteoporosis, but the pathogenesis of this bone loss is only partly understood. We assessed bone structure and remodeling at the tissu...
- Transient Receptor Potential Vanilloid 4 Activated Inflammatory Signals by Intestinal Epithelial Cells and Colitis in Mice
[作者:D'Aldebert, E; Cenac, N; Rousset, P; Martin, L; Rolland, C; Chapman, K; Selves, J; Alric, L; Vinel, JP; Vergnolle, N,期刊:Gastroenterology, 页码:275-+ , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Ligand-gated calcium channels have been reported to be involved in the pathogenesis of inflammatory bowel disease. One family member, transient receptor potential vanilloid 4 (TRPV4), is activated by a...
- Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice
[作者:Demarque, MD; Nacerddine, K; Neyret-Kahn, H; Andrieux, A; Danenberg, E; Jouvion, G; Bomme, P; Hamard, G; Romagnolo, B; Terris, B; Cumano, A; Barker, N; Clevers, H; Dejean, A,期刊:Gastroenterology, 页码:286-296 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Small ubiquitin-like modifiers (SUMOs) are attached to other proteins to regulate their function (sumoylation). We investigated the role of Ubc9, which covalently attaches SUMOs to proteins, in the gas...
- Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
[作者:Williams, CD; Stengel, J; Asike, MI; Torres, DM; Shaw, J; Contreras, M; Landt, CL; Harrison, SA,期刊:Gastroenterology, 页码:124-131 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Prevalence of nonalcoholic fatty liver disease (NAFLD) has not been well established. The purpose of this study was to prospectively define the prevalence of both NAFLD and nonalcoholic steatohepatitis...
- Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B
[作者:Heathcote, EJ; Marcellin, P; Buti, M; Gane, E; De Man, RA; Krastev, Z; Germanidis, G; Lee, SS; Flisiak, R; Kaita, K; Manns, M; Kotzev, I; Tchernev, K; Buggisch, P; Weilert, F; Kurdas, OO; Shiffman, ML; Trinh, H; Gurel, S; Snow-Lampart, A; Borroto-Esoda, K; Mondou, E; Anderson, J; Sorbel, J; Rousseau, F,期刊:Gastroenterology, 页码:132-143 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Tenofovir disoproxil fumarate (TDF), a nucleotide analogue and potent inhibitor of hepatitis B virus (HBV) polymerase, showed superior efficacy to adefovir dipivoxil in treatment of chronic hepatitis B...
- Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice
[作者:Lombardo, Y; Scopelliti, A; Cammareri, P; Todaro, M; Iovino, F; Ricci-Vitiani, L; Gulotta, G; Dieli, F; De Maria, R; Stassi, G,期刊:Gastroenterology, 页码:297-+ , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: The limited clinical response observed in many patients with colorectal cancer may be related to the presence of chemoresistant colorectal cancer stem cells (CRC-SCs). Bone morphogenetic protein 4 (BMP...
- CXCL17 and ICAM2 Are Associated With a Potential Anti-Tumor Immune Response in Early Intraepithelial Stages of Human Pancreatic Carcinogenesis
[作者:Hiraoka, N; Yamazaki-Itoh, R; Ino, Y; Mizuguchi, Y; Yamada, T; Hirohashi, S; Kanai, Y,期刊:Gastroenterology, 页码:310-+ , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Anti-tumor immunity changes over the course of tumor progression; it is not clear how or when the developing tumor overcomes immune surveillance. Intraductal papillary mucinous neoplasm (IPMN) is an in...
- Type of CFTR Mutation Determines Risk of Pancreatitis in Patients With Cystic Fibrosis
[作者:Ooi, CY; Dorfman, R; Cipolli, M; Gonska, T; Castellani, C; Keenan, K; Freedman, SD; Zielenski, J; Berthiaume, Y; Corey, M; Schibli, S; Tullis, E; Durie, PR,期刊:Gastroenterology, 页码:153-161 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Different mutations in the cystic fibrosis gene (CFTR) are associated with different functional status of the exocrine pancreas. We investigated whether CFTR genotypes determine the risk of pancreatiti...
- The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2
[作者:Wong, CCL; Wong, CM; Tung, EKK; Au, SLK; Lee, JMF; Poon, RTP; Man, K; Ng, IOL,期刊:Gastroenterology, 页码:322-331 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: We investigated mechanisms of hepatocellular carcinoma (HCC) metastasis and identified an antimetastatic microRNA (miRNA), miR-139, that is down-regulated in human HCC samples. METHODS: Effects of stab...
- HIV-Tat-Mediated Delivery of an LPTS Functional Fragment Inhibits Telomerase Activity and Tumorigenicity of Hepatoma Cells
[作者:Chen, GM; Da, LA; Wang, HF; Xu, Y; Chen, GY; Sun, CF; Wang, LM; Zhao, J; Zhang, F; Feng, JA; Wang, YF; Tiollais, P; Li, TP; Zhao, MJ,期刊:Gastroenterology, 页码:332-343 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Human liver-related putative tumor suppressor (LPTS) is a gene that encodes a telomerase inhibitory protein that is similar to human Pin2/TRF1-interacting protein. The LPTS protein binds directly to th...
- Combined Bicarbonate Conductance-Impairing Variants in CFTR and SPINK1 Variants Are Associated With Chronic Pancreatitis in Patients Without Cystic Fibrosis
[作者:Schneider, A; Larusch, J; Sun, XM; Aloe, A; Lamb, J; Hawes, R; Cotton, P; Brand, RE; Anderson, MA; Money, ME; Banks, PA; Lewis, MD; Baillie, J; Sherman, S; Disario, J; Burton, FR; Gardner, TB; Amann, ST; Gelrud, A; George, R; Rockacy, MJ; Kassabian, S; Martinson, J; Slivka, A; Yadav, D; Oruc, N; Barmada, MM; Frizzell, R; Whitcomb, DC,期刊:Gastroenterology, 页码:162-171 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Idiopathic chronic pancreatitis (ICP) is a complex inflammatory disorder associated with multiple genetic and environmental factors. In individuals without cystic fibrosis (CF), variants of CFTR that i...
- Endoscopic Ultrasonography-Guided Ethanol Lavage With Paclitaxel Injection Treats Patients With Pancreatic Cysts
[作者:Oh, HC; Seo, DW; Song, TJ; Moon, SH; Park, DH; Lee, SS; Lee, SK; Kim, MH; Kim, J,期刊:Gastroenterology, 页码:172-179 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Endoscopic ultrasonography (EUS)-guided interventions have been used to treat patients with cystic lesions of the pancreas (CLPs). We used EUS to guide injection and lavage of ethanol, followed by inje...
- Bone Disease in Patients With Primary Sclerosing Cholangitis
[作者:Angulo, P; Grandison, GA; Fong, DG; Keach, JC; Lindor, KD; Bjornsson, E; Koch, A,期刊:Gastroenterology, 页码:180-188 , 文章类型: Article,,卷期:2011年140-1]
- BACKGROUND & AIMS: Osteopenic bone disease occurs frequently among patients with chronic liver disease but has not been well studied in those with primary sclerosing cholangitis (PSC). We investigated the prevalence, rat...
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