- Cyclopiazonic Acid Biosynthesis in Aspergillus sp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releases cyclo-Acetoacetyl-L-tryptophan
[作者:Liu, XY; Walsh, CT,期刊:Biochemistry, 页码:8746-8757 , 文章类型: Article,,卷期:2009年48-36]
- The fungal neurotoxin (x-cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca2+-ATPase, has a pentacyclic indole tetramic acid scaffold that arises from one molecule of tryptophan, acetyl-CoA, malonyl-CoA, and dimethyla...
- Ion-Blocking Sites of the Kir2.1 Channel Revealed by Multiscale Modeling
[作者:Tai, KH; Stansfeld, PJ; Sansom, MSP,期刊:Biochemistry, 页码:8758-8763 , 文章类型: Article,,卷期:2009年48-36]
- The Kir2.1 potassium channel owes its inward-rectifying behavior to blocking by multivalent ions, e.g., magnesium and spermine, which access the channel from the cytoplasm and are thought to bind within the pore. To inve...
- Arabidopsis thaliana Mitochondrial Glyoxalase 2-1 Exhibits beta-Lactamase Activity
[作者:Limphong, P; Nimako, G; Thomas, PW; Fast, W; Makaroff, CA; Crowder, MW,期刊:Biochemistry, 页码:8491-8493 , 文章类型: Article,,卷期:2009年48-36]
- In an effort to determine the physiological role of Arabidopsis thaliana Glx2-1, we attempted to uncover a substrate for the enzyme. Glx2-1 did not effectively process 192 diverse substrates found in a commercial screen ...
- Fluconazole Modulates Membrane Rigidity, Heterogeneity, and Water Penetration into the Plasma Membrane in Saccharomyces cerevisiae
[作者:Abe, F; Usui, K; Hiraki, T,期刊:Biochemistry, 页码:8494-8504 , 文章类型: Article,,卷期:2009年48-36]
- Azole anitifungal drugs such as fluconazole inhibit 14 alpha-demethylase. The mechanism of fluconazole action on the plasma membrane is assumed to be ergosterol depletion and accumulation of a toxic sterol, 14 alpha-meth...
- Activation of Membrane Cholesterol by 63 Amphipaths
[作者:Lange, Y; Ye, J; Duban, ME; Steck, TL,期刊:Biochemistry, 页码:8505-8515 , 文章类型: Article,,卷期:2009年48-36]
- A few membrane-intercalating amphipaths have been observed to stimulate the interaction of cholesterol with cholesterol oxidase, saponin and cyclodextrin, presumably by displacing cholesterol laterally from its phospholi...
- Temporal Correlation of DNA Binding, ATP Hydrolysis, and Clamp Release in the Clamp Loading Reaction Catalyzed by the Escherichia coli gamma complex
[作者:Anderson, SG; Thompson, JA; Paschall, CO; O'Donnell, M; Bloom, LB,期刊:Biochemistry, 页码:8516-8527 , 文章类型: Article,,卷期:2009年48-36]
- Clamp loaders are multisubunit complexes that use the energy derived from ATP binding and hydrolysis to assemble ring-shaped sliding clamps onto DNA. Sliding clamps in turn tether DNA polymerases to the templates being c...
- N-Terminal Aliphatic Residues Dictate the Structure, Stability, Assembly, and Small Molecule Binding of the Coiled-Coil Region of Cartilage Oligomeric Matrix Protein
[作者:Gunasekar, SK; Asnani, M; Limbad, C; Haghpanah, JS; Hom, W; Barra, H; Nanda, S; Lu, M; Montclare, JK,期刊:Biochemistry, 页码:8559-8567 , 文章类型: Article,,卷期:2009年48-36]
- The coiled-coil domain of cartilage oligomeric matrix protein (COMPcc) assembles into a homopentamer that naturally recognizes the small molecule 1,25-dihydroxyvitamin D-3 (vit D). To identify the residues critical for t...
- F-19 NMR Studies of alpha-Synuclein Conformation and Fibrillation
[作者:Li, CG; Lutz, EA; Slade, KM; Ruf, RAS; Wang, GF; Pielak, GJ,期刊:Biochemistry, 页码:8578-8584 , 文章类型: Article,,卷期:2009年48-36]
- Fibrils of the intrinsically disordered protein alpha-synuclein are hallmarks of Parkinson's disease. The fluorescent dye thioflavin T is often used to characterize fibrillation, but this assay may not provide quantitati...
- Comparative Photochemistry of Animal Type 1 and Type 4 Cryptochromes
[作者:Ozturk, N; Selby, CP; Song, SH; Ye, R; Tan, C; Kao, YT; Zhong, DP; Sancar, A,期刊:Biochemistry, 页码:8585-8593 , 文章类型: Article,,卷期:2009年48-36]
- Cryptochromes (CRYs) are blue-light photoreceptors with known or presumed functions in light-dependent and light-independent gene regulation in plants and animals. Although the photochemistry of plant CRYs has been studi...
- Structural Characterization of the Conformational Change in Calbindin-D-28k upon Calcium Binding Using Differential Surface Modification Analyzed by Mass Spectrometry
[作者:Hobbs, CA; Deterding, LJ; Perera, L; Bobay, BG; Thompson, RJ; Darden, TA; Cavanagh, J; Tomer, KB,期刊:Biochemistry, 页码:8603-8614 , 文章类型: Article,,卷期:2009年48-36]
- Calbindin-D-28k is a calcium binding protein with six EF hand domains. Calbindin-D-28k is unique in that it functions as both a calcium buffer and a sensor protein. It is found in many tissues, including brain, pancreas,...
|