- Purification and Characterization of the Lipid A Disaccharide Synthase (LpxB) from Escherichia coli, a Peripheral Membrane Protein
[作者:Metzger, LE; Raetz, CRH,期刊:Biochemistry, 页码:11559-11571 , 文章类型: Article,,卷期:2009年48-48]
- Escherichia coli LpxB, an inverting glycosyl transferase of the GT-B superfamily and a member of CAZy database family 19, catalyzes the fifth step of lipid A biosynthesis: UDP-2,3-diacylglucosamine + 2, 3-diacylglucosami...
- The Structural Basis of Pregnane X Receptor Binding Promiscuity
[作者:Ngan, CH; Beglov, D; Rudnitskaya, AN; Kozakov, D; Waxman, DJ; Vajda, S,期刊:Biochemistry, 页码:11572-11581 , 文章类型: Article,,卷期:2009年48-48]
- The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structurally diverse compounds. The structures of the apo and ligand-bound forms of PXR are very similar, ill contrast to most ...
- Mechanism of Fibril Formation by a 39-Residue Peptide (PAPf39) from Human Prostatic Acidic Phosphatase
[作者:Ye, ZQ; French, KC; Popova, LA; Lednev, IK; Lopez, MM; Makhatadze, GI,期刊:Biochemistry, 页码:11582-11591 , 文章类型: Article,,卷期:2009年48-48]
- PAPf39 is a 39-residue peptide fragment from the sequence of human prostatic acidic phosphatase, This peptide was shown to form amyloid-like fibrils, which have been implicated in facilitating semen-mediated HIV transmis...
- Reversible Chemical Step and Rate-Limiting Enzyme Regeneration in the Reaction Catalyzed by Formamidopyrimidine-DNA Glycosylase
[作者:Kuznetsov, NA; Zharkov, DO; Koval, VV; Buckle, M; Fedorova, OS,期刊:Biochemistry, 页码:11335-11343 , 文章类型: Article,,卷期:2009年48-48]
- Formamidopyrimidine-DNA N-glycosylase (Fpg) operates in the base excision repair pathway ill bacteria by removing oxidized guanine bases from DNA and can also cleave the nascent or preformed abasic DNA by P,beta,delta-el...
- The 8 and 5 kDa Fragments of Plasma Gelsolin Form Amyloid Fibrils by a Nucleated Polymerization Mechanism, while the 68 kDa Fragment Is Not Amyloidogenic
[作者:Solomon, JP; Yonemoto, IT; Murray, AN; Price, JL; Powers, ET; Balch, WE; Kelly, JW,期刊:Biochemistry, 页码:11370-11380 , 文章类型: Article,,卷期:2009年48-48]
- Familial amyloidosis of Finnish type (FAF), or gelsolin amyloidosis, is a systemic amyloid disease caused by a mutation (D187N/-Y) in domain 2 of human plasma gelsolin, resulting in domain 2 misfolding within the secreto...
- Structural, Thermodynamic, and Kinetic Effects of a Phosphomimetic Mutation in Dynein Light Chain LC8
[作者:Benison, G; Chiodo, M; Karplus, PA; Barbar, E,期刊:Biochemistry, 页码:11381-11389 , 文章类型: Article,,卷期:2009年48-48]
- Dynein light chain LC8 is a small, dimeric, very highly conserved globular protein first identified as an integral part or the dynein and myosin molecular motors but now recognized as a dimerization hub with wider signif...
- Kinetic Stability of the Flavin Semiquinone in Photolyase and Cryptochrome-DASH
[作者:Damiani, MJ; Yalloway, GN; Lu, J; McLeod, NR; O'Neill, MA,期刊:Biochemistry, 页码:11399-11411 , 文章类型: Article,,卷期:2009年48-48]
- Photolyases and cryptochromes (CRY) are structurally homologous flavoproteins with divergent functions. While photolyases repair UV-damaged DNA by photoinduced electron transfer from their FAD cofactor, CRY are involved ...
- Kinetic Characterization of Xenobiotic Reductase A from Pseudomonas putida 86
[作者:Spiegelhauer, O; Dickert, F; Mende, S; Niks, D; Hille, R; Ullmann, M; Dobbek, H,期刊:Biochemistry, 页码:11412-11420 , 文章类型: Article,,卷期:2009年48-48]
- Xenobiotic reductase A (XenA) from Pseudomonas putida is a member of the old-yellow-enzyme family of flavin-containing enzymes and catalyzes the NADH/NADPH-dependent reduction of various substrates, including 8-hydroxyco...
- Assembly with the Na,K-ATPase alpha(1) Subunit Is Required for Export of beta(1) and beta(2) Subunits from the Endoplasmic Reticulum
[作者:Tokhtaeva, E; Sachs, G; Vagin, O,期刊:Biochemistry, 页码:11421-11431 , 文章类型: Article,,卷期:2009年48-48]
- The level of the heterodimeric Na,K-ATPase is tightly controlled in epithelia to maintain appropriate transport function. The catalytic Na,K-ATPase alpha subunit is not able to exit the ER or catalyze ion transport unles...
- Allosteric Interactions Direct Binding and Phosphorylation of ASF/SF2 by SRPK1
[作者:Huynh, N; Ma, CT; Giang, N; Hagopian, J; Ngo, J; Adams, J; Ghosh, G,期刊:Biochemistry, 页码:11432-11440 , 文章类型: Article,,卷期:2009年48-48]
- ASF/SF2, a member of the serine-arginine (SR) protein family, has two RRM domains (RRM1 and RRM2) and a C-terminal domain rich in RS dipeptides. SR protein kinase 1 (SRPK1) phosphorylates approximately 12 of these serine...
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