BI-1356 is a dipeptidyl-peptidase IV (DPP IV, or CD26) inhibitor developed at Boehringer Ingelheim for the treatment of type 2 diabetes. BI-1356 demonstrated long-lasting DPP IV inhibition both in vitro and in vivo. I...

Soft tissue sarcomas (STS) are a group of rare tumors, most of which are relatively resistant to standard chemotherapeutic agents. To date, favorable efficacy data exist for only a small number of agents in this disea...

Oncolytic viruses infect, replicate in and lyse tumor cells while sparing normal cells. In addition to direct lysis, viruses induce antitumor immunity and some viruses express cytotoxic proteins. Oncolytic viruses can...

Sagopilone is a fully synthetic epothilone. Epothilones are cytotoxic antimicrotubule drugs, six of which have been studied in clinical trials. Sagopilone has potential advantages over other antimicrotubule agents suc...

Ginseng is a medicinal plant valued throughout the world and is considered the king of herbs in traditional Chinese/Oriental medicine. Ginseng has gained popularity as a dietary supplement in the United States and Can...

Angiogenesis, or the process by which new vessels are created from preexisting vasculature, has become the subject of intense research in recent years. Increased rates of angiogenesis are associated with several disea...

Increasing attention is being dedicated towards the lowering of plasma homocysteine concentrations in order to preclude cognitive impairment in the elderly based on various observational studies that have shown an inv...

Breast cancer resistance protein (BCRP, MXR, ABCG2) is a well-known protein related to acute myeloid leukemia (AML) resistance to chemotherapeutic treatments. This protein is a member of the ATP-binding cassette famil...

POEMS syndrome is a paraneoplastic disorder secondary to plasma cell dyscrasia. It is characterized by the presence of polyneuropathy (P), organomegaly (0), endocrinopathy (E), monoclonal gammopathy (M) and skin chang...

Advances continue to be made in the field of antiretroviral therapy. New agents are progressing through various stages of preclinical and clinical development. New studies add to our understanding of how best to use t...