Atacicept (TACI-Ig, TACE-Fc5) is a soluble recombinant fusion protein containing the extracellular BAFF/APRIL-binding domain of the TACI receptor and the Fe region of human IgG that blocks both BAFF and APRIL, two mem...

The complex metabolic disorder type 2 diabetes is a leading cause of morbidity and mortality worldwide and thus a health and economic burden. Daiichi Sankyo, has developed a new thiazolidinedione candidate for the tre...

SNS-032 (formerly BMS-387032) is a small-molecule cyclin-dependent kinase (CDK) inhibitor currently in phase I clinical trials for the treatment of B-cell malignancies and advanced solid tumors. Preclinical studies ha...

Incretin agonists and analogues are receiving increasing attention as potential antidiabetic agents due to their ability to stimulate insulin secretion only during hyperglycemic states. Exploitation of the incretin ef...

Skin hyperpigmentation can be a serious aesthetic problem with severe psychological impact. Skin color is determined by the type and quantity of melanin, a dark pigment produced by melanocytes. The initial rate-limiti...

Hepatocyte growth factor (HGF) is a mesenchymally derived heterodimeric glycoprotein that was first recognized as a stimulator of hepatocyte proliferation. It is now known that HGF, as a multipotent cytokine, plays a ...

Latent autoimmune diabetes in adults (LADA) is an autoimmune form of diabetes that presents with circulating autoantibodies, is slowly progressive and does not initially require insulin therapy. Although it has been q...

Cancer of all types is the second leading cause of death in the United States. While there are many different treatment options, antimetabolites inhibit aberrant cell growth by interfering with the formation or utiliz...

Schizophrenia is a psychiatric illness characterized by disturbances of cognition and thought, affecting language, perception and sense of self. The treatment of schizophrenia involves drug therapy to relieve symptoms...