- Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia
[作者：Konieczna, I; Horvath, E; Wang, H; Lindsey, S; Saberwal, G; Bei, L; Huang, WQ; Platanias, L; Eklund, EA,期刊：Journal of clinical investigation, 页码：853-867 , 文章类型： Article，,卷期：2008年118-3]
- Myeloproliferative disorders (MPDs) are characterized by cytokine hypersensitivity and apoptosis resistance. Development of a block in myeloid differentiation is associated with progression of MPD to acute myeloid leukem...
- The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
[作者：Morimoto, T; Sunagawa, Y; Kawamura, T; Takaya, T; Wada, H; Nagasawa, A; Komeda, M; Fujita, M; Shimatsu, A; Kita, T; Hasegawa, K,期刊：Journal of clinical investigation, 页码：868-878 , 文章类型： Article，,卷期：2008年118-3]
- Hemodynamic overload in the heart can trigger maladaptive hypertrophy of cardiomyocyres. A key signaling event in this process is nuclear acetylation by histone deacetylases and p300, an intrinsic histone acetyltransfera...
- Curcumin prevents and reverses murine cardiac hypertrophy
[作者：Li, HL; Liu, C; de Couto, G; Ouzounian, M; Sun, M; Wang, AB; Huang, Y; He, CW; Shi, Y; Chen, X; Nghiem, MP; Liu, YA; Chen, MY; Dawood, F; Fukuoka, M; Maekawa, Y; Zhang, LY; Leask, A; Ghosh, AK; Kirshenbaum, LA; Liu, PP,期刊：Journal of clinical investigation, 页码：879-893 , 文章类型： Article，,卷期：2008年118-3]
- Chromatin remodeling, particularly histone acetylation, plays a critical role in the progression of pathological cardiac hypertrophy and heart failure. We hypothesized that curcumin, a natural polyphenolic compound abund...
- Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes
[作者：Christoforou, N; Miller, RA; Hill, CM; Jie, CC; McCallion, AS; Gearhart, JD,期刊：Journal of clinical investigation, 页码：894-903 , 文章类型： Article，,卷期：2008年118-3]
- Although the differentiation of ES cells to cardiomyocytes has been firmly established, the extent to which corresponding cardiac precursor cells can contribute to other cardiac populations remains unclear. To determine ...
- HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse
[作者：Connell, KA; Guess, MK; Chen, H; Andikyan, V; Bercik, R; Taylor, HS,期刊：Journal of clinical investigation, 页码：1050-1055 , 文章类型： Article，,卷期：2008年118-3]
- Pelvic organ prolapse (POP) is a common, debilitating disorder affecting millions of women. Uterosacral ligaments (USLs) are the main supportive structures of the uterus and vagina and are often attenuated in women with ...
- Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure
[作者：Wang, WH; McNatt, LG; Pang, IH; Millar, C; Hellberg, PE; Hellberg, MH; Steely, HT; Rubin, JS; Fingert, JH; Sheffield, VC; Stone, EM; Clark, AF,期刊：Journal of clinical investigation, 页码：1056-1064 , 文章类型： Article，,卷期：2008年118-3]
- Elevated intraocular pressure (IOP) is the principal risk factor for glaucoma and results from excessive impedance of the fluid outflow from the eye. This abnormality likely originates from outflow pathway tissues such a...
- Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain
[作者：Zollner, C; Mousa, SA; Fischer, O; Rittner, HL; Shaqura, M; Brack, A; Shakibaei, M; Binder, W; Urban, F; Stein, C; Schafer, M,期刊：Journal of clinical investigation, 页码：1065-1073 , 文章类型： Article，,卷期：2008年118-3]
- Although opioids are highly effective analgesics, they are also known to induce cellular adaptations resulting in tolerance. Experimental studies are often performed in the absence of painful tissue injury, which preclud...
- Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling
[作者：Balabanian, K; Levoye, A; Klemm, L; Lagane, B; Hermine, O; Harriague, J; Baleux, F; Arenzana-Seisdedos, F; Bachelerie, F,期刊：Journal of clinical investigation, 页码：1074-1084 , 文章类型： Article，,卷期：2008年118-3]
- Leukocytes from individuals with warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a rare immunodeficiency, and bearing a wild-type CXCR4 ORF (WHIMWT) display impaired CXCR4 internalization and...
- Growth hormone enhances thymic function in HIV-1-infected adults
[作者：Napolitano, LA; Schmidt, D; Gotway, MB; Ameli, N; Filbert, EL; Ng, MM; Clor, JL; Epling, L; Sinclair, E; Baum, PD; Li, K; Killian, ML; Bacchetti, P; McCune, JM,期刊：Journal of clinical investigation, 页码：1085-1098 , 文章类型： Article，,卷期：2008年118-3]
- Growth hormone (GH) is an underappreciated but important regulator of T cell development that can reverse age-related declines in thymopoiesis in rodents. Here, we report findings of a prospective randomized study examin...
- Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells
[作者：Takahashi, Y; Harashima, N; Kajigaya, S; Yokoyama, H; Cherkasova, E; Mccoy, JP; Hanada, K; Mena, O; Kurlander, R; Abdul, T; Srinivasan, R; Lundqvist, A; Malinzak, E; Geller, N; Lerman, MI; Childs, RW,期刊：Journal of clinical investigation, 页码：1099-1109 , 文章类型： Article，,卷期：2008年118-3]
- Transplanted donor lymphocytes infused during hematopoietic stem cell transplantation (HSCT) have been shown to cure patients with hematological malignancies. However, less is known about the effects of HSCT on metastati...
- A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI
[作者：von zur Muhlen, C; Sibson, NR; Peter, K; Campbell, SJ; Wilainam, P; Grau, GE; Bode, C; Choudhury, RP; Anthony, DC,期刊：Journal of clinical investigation, 页码：1198-1207 , 文章类型： Article，,卷期：2008年118-3]
- Human and murine cerebral malaria are associated with elevated levels of cytokines in the brain and adherence of platelets to the microvasculature. Here we demonstrated that the accumulation of platelets in the brain mic...
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