- Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms
[作者:Li, ZG; Mathew, P; Yang, J; Starbuck, MW; Zurita, AJ; Liu, J; Sikes, C; Multani, AS; Efstathiou, E; Lopez, A; Wang, J; Fanning, TV; Prieto, VG; Kundra, V; Vazquez, ES; Troncoso, P; Raymond, AK; Logothetis, CJ; Lin, SH; Maity, S; Navone, NM,期刊:Journal of clinical investigation, 页码:2697-2710 , 文章类型: Article,,卷期:2008年118-8]
- In prostate cancer, androgen blockade strategies are commonly used to treat osteoblastic bone metastases. However, responses to these therapies are typically brief, and the mechanism underlying androgen-independent progr...
- KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis
[作者:Narla, G; Difeo, A; Fernandez, Y; Dhanasekaran, S; Huang, F; Sangodkar, J; Hod, E; Leake, D; Friedman, SL; Hall, SJ; Chinnaiyan, AM; Gerald, WL; Rubin, MA; Martignetti, JA,期刊:Journal of clinical investigation, 页码:2711-2721 , 文章类型: Article,,卷期:2008年118-8]
- Metastatic prostate cancer (PCa) is one of the leading causes of death from cancer in men. The molecular mechanisms underlying the transition from localized tumor to hormone-refractory metastatic PCa remain largely unkno...
- Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
[作者:Hoot, KE; Lighthall, J; Han, G; Lu, SL; Li, A; Ju, W; Kulesz-Martin, M; Bottinger, E; Wang, XJ,期刊:Journal of clinical investigation, 页码:2722-2732 , 文章类型: Article,,卷期:2008年118-8]
- TGF-beta and its signaling mediators, Smad2,-3, and -4, are involved with tumor suppression and promotion functions. Smad4(-/-) mouse epidermis develops spontaneous skin squamous cell carcinomas (SCCs), and Smad3(-/-) mi...
- Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice
[作者:Jiang, M; Bujo, H; Ohwaki, K; Unoki, H; Yarnazaki, H; Kanaki, T; Shibasaki, M; Azuma, K; Harigaya, K; Schneider, WJ; Saito, Y,期刊:Journal of clinical investigation, 页码:2733-2746 , 文章类型: Article,,卷期:2008年118-8]
- Medial-to-intimal migration of SMCs is critical to atherosclerotic plaque formation and remodeling of injured arteries. Considerable amounts of the shed soluble form of the LDL receptor relative LR11 (sLR11) produced by ...
- Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation
[作者:Sassi, Y; Lipskaia, L; Vandecasteele, G; Nikolaev, VO; Hatem, SN; Aubart, FC; Flussel, FG; Mougenot, N; Vrignaud, C; Lechat, P; Lompre, AM; Hulot, JS,期刊:Journal of clinical investigation, 页码:2747-2757 , 文章类型: Article,,卷期:2008年118-8]
- The second messengers cAMP and cGMP can be degraded by specific members of the phosphodiesterase superfamily or by active efflux transporters, namely the multidrug resistance-associated proteins (MRPs) MRP4 and MRP5. To ...
- Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
[作者:Lim, BK; Xiong, D; Dorner, A; Youn, TJ; Yung, A; Liu, TI; Gu, Y; Dalton, ND; Wright, AT; Evans, SM; Chen, J; Peterson, KL; McCulloch, AD; Yajima, T; Knowlton, KU,期刊:Journal of clinical investigation, 页码:2758-2770 , 文章类型: Article,,卷期:2008年118-8]
- The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that belongs to the family of adhesion molecules. In the postnatal heart, it is localized predominantly at the intercalated disc, where its func...
- Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I
[作者:Dickson, P; Peinovich, M; McEntee, M; Lester, T; Le, S; Krieger, A; Manuel, H; Jabagat, C; Passage, M; Kakkis, ED,期刊:Journal of clinical investigation, 页码:2868-2876 , 文章类型: Article,,卷期:2008年118-8]
- Mucopolysaccharidoses (MPSs) are lysosomal storage diseases caused by a deficit in the enzymes needed for glycosaminoglycan (GAG) degradation. Enzyme replacement therapy with recombinant human alpha-L-iduronidase success...
- Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant K-ATP channel mutations
[作者:Pinney, SE; MacMullen, C; Becker, S; Lin, YW; Hanna, C; Thornton, P; Ganguly, A; Shyng, SL; Stanley, CA,期刊:Journal of clinical investigation, 页码:2877-2886 , 文章类型: Article,,卷期:2008年118-8]
- Congenital hyperinsulinism is a condition of dysregulated insulin secretion often caused by inactivating mutations of the ATP-sensitive K+ (K-ATP) channel in the pancreatic P cell. Though most disease-causing mutations o...
- Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice
[作者:Kang, MJ; Lee, CG; Lee, JY; Dela Cruz, CS; Chen, ZJ; Enelow, R; Elias, JA,期刊:Journal of clinical investigation, 页码:2771-2784 , 文章类型: Article,,卷期:2008年118-8]
- Viral infections have more severe consequences in patients who have been exposed to cigarette smoke (CS) than in those not exposed to CS. For example, in chronic obstructive pulmonary disease (COPD), viruses cause more s...
- Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice
[作者:Sheng, G; Xu, X; Lin, YF; Wang, CE; Rong, J; Cheng, D; Peng, J; Jiang, X; Li, SH; Li, XJ,期刊:Journal of clinical investigation, 页码:2785-2795 , 文章类型: Article,,卷期:2008年118-8]
- Joubert syndrome is an autosomal recessive disorder characterized by congenital malformation of the cerebellum and brainstem, with abnormal decussation in the brain. Mutations in the Abelson helper integration site 1 gen...
- Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
[作者:Trinchese, F; Fa, M; Liu, S; Zhang, H; Hidalgo, A; Schmidt, SD; Yarnaguchi, H; Yoshii, N; Mathews, PM; Nixon, RA; Arancio, O,期刊:Journal of clinical investigation, 页码:2796-2807 , 文章类型: Article,,卷期:2008年118-8]
- Calpains are calcium-dependent enzymes that determine the fate of proteins through regulated proteolytic activity. Calpains have been linked to the modulation of memory and are key to the pathogenesis of Alzheimer diseas...
- FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets
[作者:Nishino, N; Tamori, Y; Tateya, S; Kawaguchi, T; Shibakusa, T; Mizunoya, W; Inoue, K; Kitazawa, R; Kitazawa, S; Matsuki, Y; Hiramatsu, R; Masubuchi, S; Omachi, A; Kimura, K; Saito, M; Amo, T; Ohta, S; Yamaguchi, T; Osumi, T; Cheng, J; Fujimoto, T; Nakao, H; Nakao, K; Aiba, A; Okamura, H; Fushiki, T; Kasuga, M,期刊:Journal of clinical investigation, 页码:2808-2821 , 文章类型: Article,,卷期:2008年118-8]
- White adipocytes are unique in that they contain large unilocular lipid droplets that occupy most of the cytoplasm. To identify genes involved in the maintenance of mature adipocytes, we expressed dominant-negative PPAR ...
- Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice
[作者:Falardeau, J; Chung, WCJ; Beenken, A; Raivio, T; Plummer, L; Sidis, Y; Jacobson-Dickman, EE; Eliseenkova, AV; Ma, J; Dvfyer, A; Quinton, R; Na, S; Hall, JE; Huot, C; Alois, N; Pearce, SHS; Cole, LW; Hughes, V; Mohammadi, M; Tsai, P; Pitteloud, N,期刊:Journal of clinical investigation, 页码:2822-2831 , 文章类型: Article,,卷期:2008年118-8]
- Idiopathic hypogonadotropic hypogonadism (IHH) with anosmia (Kallmann syndrome; KS) or with a normal sense of smell (normosmic IHH; nIHH) are heterogeneous genetic disorders associated with deficiency of gonadotropin-rel...
- Link controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
[作者:Bersenev, A; Wu, C; Balcerek, J; Tong, W,期刊:Journal of clinical investigation, 页码:2832-2844 , 文章类型: Article,,卷期:2008年118-8]
- In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mp1, or Mp1), controls HSC homeostasis and s...
- Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients
[作者:Martinez-Llordella, M; Lozano, JJ; Puig-Pey, I; Orlando, G; Tisone, G; Lerut, J; Benitez, C; Pons, JA; Parrilla, P; Ramirez, P; Bruguera, M; Rimola, A; Sanchez-Fueyo, A,期刊:Journal of clinical investigation, 页码:2845-2857 , 文章类型: Article,,卷期:2008年118-8]
- A fraction of liver transplant recipients are able to discontinue all immunosuppressive therapies without rejecting their grafts and are said to be operationally tolerant to the transplant. However, accurate identificati...
- Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria
[作者:Pey, AL; Ying, M; Cremades, N; Velazquez-Campoy, A; Scherer, T; Thony, B; Sancho, J; Martinez, A,期刊:Journal of clinical investigation, 页码:2858-2867 , 文章类型: Article,,卷期:2008年118-8]
- Phenylketonuria (PKU) is an inborn error of metabolism caused by mutations in phenylalanine hydroxylase (PAH). Over 500 disease-causing mutations have been identified in humans, most of which result in PAH protein misfol...
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