- Maintenance of cardiac energy by histone deacetylase 3 metabolism in mice
[作者:Montgomery, RL; Potthoff, MJ; Haberland, M; Qi, XX; Matsuzaki, S; Humphries, KM; Richardson, JA; Bassel-Duby, R; Olson, EN,期刊:Journal of clinical investigation, 页码:3588-3597 , 文章类型: Article,,卷期:2008年118-11]
- Histone deacetylase (HDAC) inhibitors show remarkable therapeutic potential for a variety of disorders, including cancer, neurological disease, and cardiac hypertrophy. However, the specific HDAC isoforms that mediate th...
- Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation
[作者:Frey, N; Frank, D; Lippl, S; Kuhn, C; Kogler, H; Barrientos, T; Rohr, C; Will, R; Muller, OJ; Weiler, H; Bassel-Duby, R; Katus, HA; Olson, EN,期刊:Journal of clinical investigation, 页码:3598-3608 , 文章类型: Article,,卷期:2008年118-11]
- The composition of skeletal muscle, in terms of the relative number of slow- and fast-twitch fibers, is tightly regulated to enable an organism to respond and adapt to changing physical demands. The phosphatase calcineur...
- Anticancer therapy: boosting the bang of Bim
[作者:Hendrickson, AW; Meng, XW; Kaufmann, SH,期刊:Journal of clinical investigation, 页码:3582-3584 , 文章类型: Editorial Material,,卷期:2008年118-11]
- Even though activating mutations of B-Raf, a kinase atop the MAPK signaling cascade, reportedly sensitize tumor cells to MEK inhibitors, Raf and MEK inhibitors have exhibited limited clinical activity. In this issue of t...
- Deletion of GSK-3 beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation
[作者:Kerkela, R; Kockeritz, L; MacAulay, K; Zhou, J; Doble, BW; Beahm, C; Greytak, S; Woulfe, K; Trivedi, CM; Woodgett, JR; Epstein, JA; Force, T; Huggins, GS,期刊:Journal of clinical investigation, 页码:3609-3618 , 文章类型: Article,,卷期:2008年118-11]
- Based on extensive preclinical data, glycogen synthase kinase-3 (GSK-3) has been proposed to be a viable drug target for a wide variety of disease states, ranging from diabetes to bipolar disorder. Since these new drugs,...
- GSK-3 beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism (Retraction of vol 118, pg 3279, 2008)
[作者:Kapoor, M; Liu, SX; Xu, SW; Huh, K; McCann, M; Denton, CP; Woodgerr, JR; Abraham, DJ; Leask, A,期刊:Journal of clinical investigation, 页码:3812-3812 , 文章类型: Correction,,卷期:2008年118-11]
-
- Conferring indirect allospecificity on CD4(+)CD25(+) Tregs by TCR gene transfer favors transplantation tolerance in mice
[作者:Tsang, JYS; Tanriver, Y; Jiang, SP; Xue, SA; Ratnasothy, K; Chen, DX; Stauss, HJ; Bucy, RP; Lombardi, G; Lechler, R,期刊:Journal of clinical investigation, 页码:3619-3628 , 文章类型: Article,,卷期:2008年118-11]
- T cell responses to MHC-mismatched transplants can be mediated via direct recognition of allogeneic MHC molecules on the cells of the transplant or via recognition of allogeneic peptides presented on the surface of recip...
|