- Enzymatic Activities of Isolated Cytochrome bc(1)-like Complexes Containing Fused Cytochrome b Subunits with Asymmetrically Inactivated Segments of Electron Transfer Chains
[作者:Czapla, M; Borek, A; Sarewicz, M; Osyczka, A,期刊:Biochemistry, 页码:829-835 , 文章类型: Article,,卷期:2012年51-4]
- Homodimeric structure of cytochrome bc(1), a common component of biological energy conversion systems, builds in four catalytic quinone oxidation/reduction sites and four chains of cofactors (branches) that, connected by...
- Mapping General Anesthetic Binding Site(s) in Human alpha 1 beta 3 gamma-Aminobutyric Acid Type A Receptors with [H-3]TDBzl-Etomidate, a Photoreactive Etomidate
[作者:Chiara, DC; Dostalova, Z; Jayakar, SS; Zhou, XJ; Miller, KW; Cohen, JB,期刊:Biochemistry, 页码:836-847 , 文章类型: Article,,卷期:2012年51-4]
- The gamma-aminobutyric acid type A receptor (GABAAR) is a target for general anesthetics of diverse chemical structures, which act as positive allosteric modulators at clinical doses. Previously, in a heterogeneous mixtu...
- Pre-Steady-State Kinetic Characterization of Thiolate Anion Formation in Human Leukotriene C-4 Synthase
[作者:Rinaldo-Matthis, A; Ahmad, S; Wetterholm, A; Lachmann, P; Morgenstern, R; Haeggstrom, JZ,期刊:Biochemistry, 页码:848-856 , 文章类型: Article,,卷期:2012年51-4]
- Human leukotriene C-4 synthase (hLTC4S) is an integral membrane protein that catalyzes the committed step in the biosynthesis of cysteinyl-leukotrienes, i.e., formation of leukotriene C-4 (LTC4). This molecule, together ...
- Evidence in Support of Lysine 77 and Histidine 96 as Acid-Base Catalytic Residues in Saccharopine Dehydrogenase from Saccharomyces cerevisiae
[作者:Kumar, VP; Thomas, LM; Bobyk, KD; Andi, B; Cook, PF; West, AH,期刊:Biochemistry, 页码:857-866 , 文章类型: Article,,卷期:2012年51-4]
- Saccharopine dehydrogenase (SDH) catalyzes the final reaction in the alpha-aminoadipate pathway, the conversion of L-saccharopine to L-lysine (Lys) and alpha-ketoglutarate (alpha-kg) using NAD(+) as an oxidant. The enzym...
- Essential Role of the Donor Acyl Carrier Protein in Stereoselective Chain Trans location to a Fully Reducing Module of the Nanchangmycin Polyketide Synthase
[作者:Guo, X; Liu, TG; Deng, ZX; Cane, DE,期刊:Biochemistry, 页码:879-887 , 文章类型: Article,,卷期:2012年51-4]
- Incubation of recombinant module 2 of the polyether nanchangmycin synthase (NANS), carrying an appended thioesterase domain, with the ACP-bound substrate (2RS)-2-methyl-3-ketobutyryl-NANS_ACP1 (2-ACP1) and methylmalonyl-...
- Conformational Characterization of Synapse-Associated Protein 97 by Nuclear Magnetic Resonance and Small-Angle X-ray Scattering Shows Compact and Elongated Forms
[作者:Tully, MD; Grossmann, JG; Phelan, M; Pandelaneni, S; Leyland, M; Lian, LY,期刊:Biochemistry, 页码:899-908 , 文章类型: Article,,卷期:2012年51-4]
- Synapse-associated protein 97 (SAP97) is a membrane-associated guanylate kinase protein that interacts with other proteins such as ion channels, subunits of glutamate receptors, and other cytoskeletal proteins and molecu...
- Activation of Human Mitochondrial Lysyl-tRNA Synthetase upon Maturation of Its Premitochondrial Precursor
[作者:Dias, J; Octobre, G; Kobbi, L; Comisso, M; Flisiak, S; Mirande, M,期刊:Biochemistry, 页码:909-916 , 文章类型: Article,,卷期:2012年51-4]
- The cytoplasmic and mitochondrial species of human lysyl-tRNA synthetase are encoded by a single gene by means of alternative splicing of the KARS1 gene. The cytosolic enzyme possesses a eukaryote-specific N-terminal pol...
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