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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas [作者：Okayama, H; Kohno, T; Ishii, Y; Shimada, Y; Shiraishi, K; Iwakawa, R; Furuta, K; Tsuta, K; Shibata, T; Yamamoto, S; Watanabe, S; Sakamoto, H; Kumamoto, K; Takenoshita, S; Gotoh, N; Mizuno, H; Sarai, A; Kawano, S; Yamaguchi, R; Miyano, S; Yokota, J,期刊：Cancer research, 页码：100-111 , 文章类型： Article，,卷期：2012年72-1] Activation of the EGFR, KRAS, and ALK oncogenes defines 3 different pathways of molecular pathogenesis in lung adenocarcinoma. However, many tumors lack activation of any pathway (triple-negative lung adenocarcinomas) po... Integrative Genomic Analyses of Sporadic Clear Cell Renal Cell Carcinoma Define Disease Subtypes and Potential New Therapeutic Targets [作者：Dondeti, VR; Wubbenhorst, B; Lal, P; Gordan, JD; D'Andrea, K; Attiyeh, EF; Simon, MC; Nathanson, KL,期刊：Cancer research, 页码：112-121 , 文章类型： Article，,卷期：2012年72-1] Sporadic clear cell renal cell carcinoma (ccRCC), the most common type of adult kidney cancer, is often associated with genomic copy number aberrations on chromosomes 3p and 5q. Aberrations on chromosome 3p are associate... CXCR4 Activation Defines a New Subgroup of Sonic Hedgehog-Driven Medulloblastoma [作者：Sengupta, R; Dubuc, A; Ward, S; Yang, LH; Northcott, P; Woerner, BM; Kroll, K; Luo, JQ; Taylor, MD; Wechsler-Reya, RJ; Rubin, JB,期刊：Cancer research, 页码：122-132 , 文章类型： Article，,卷期：2012年72-1] Medulloblastoma prognosis tends to be poor, despite aggressive therapy, but defining molecular subgroups may identify patients who could benefit from targeted therapies. This study used human gene array and associated cl... Global Characterization of the SRC-1 Transcriptome Identifies ADAM22 as an ER-Independent Mediator of Endocrine-Resistant Breast Cancer [作者：McCartan, D; Bolger, JC; Fagan, A; Byrne, C; Hao, Y; Qin, L; McIlroy, M; Xu, JM; Hill, AD; Gaora, PO; Young, LS,期刊：Cancer research, 页码：220-229 , 文章类型： Article，,卷期：2012年72-1] The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity that permits the emergence of a hormone-independent tumor. The steroid coactivator protein SRC-1, through i... HMGB1 Promotes Drug Resistance in Osteosarcoma [作者：Huang, J; Ni, JD; Liu, K; Yu, Y; Xie, M; Kang, R; Vernon, P; Cao, LZ; Tang, DL,期刊：Cancer research, 页码：230-238 , 文章类型： Article，,卷期：2012年72-1] Osteosarcoma is the most commonly occurring bone cancer in children and adolescents. Unfortunately, treatment failures are common due to the development of chemoresistance, for which the underlying molecular mechanisms r... Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature [作者：Fokas, E; Im, JH; Hill, S; Yameen, S; Stratford, M; Beech, J; Hackl, W; Maira, SM; Bernhard, EJ; McKenna, WG; Muschel, RJ,期刊：Cancer research, 页码：239-248 , 文章类型： Article，,卷期：2012年72-1] The aberrant vascular architecture of solid tumors results in hypoxia that limits the efficacy of radiotherapy. Vascular normalization using antiangiogenic agents has been proposed as a means to improve radiation therapy... Transcriptional and Nontranscriptional Functions of E2F1 in Response to DNA Damage [作者：Biswas, AK; Johnson, DG,期刊：Cancer research, 页码：13-17 , 文章类型： Review，,卷期：2012年72-1] E2F is a family of transcription factors that regulate the expression of genes involved in a wide range of cellular processes, including cell-cycle progression, DNA replication, DNA repair, differentiation, and apoptosis... Metastasis Suppressor NM23-H1 Promotes Repair of UV-Induced DNA Damage and Suppresses UV-Induced Melanomagenesis [作者：Jarrett, SG; Novak, M; Dabernat, S; Daniel, JY; Mellon, I; Zhang, QB; Harris, N; Ciesielski, MJ; Fenstermaker, RA; Kovacic, D; Slominski, A; Kaetzel, DM,期刊：Cancer research, 页码：133-143 , 文章类型： Article，,卷期：2012年72-1] Reduced expression of the metastasis suppressor NM23-H1 is associated with aggressive forms of multiple cancers. Here, we establish that NM23-H1 (termed H1 isoform in human, M1 in mouse) and two of its attendant enzymati... Opposing Effects of Pigment Epithelium-Derived Factor on Breast Cancer Cell versus Neuronal Survival: Implication for Brain Metastasis and Metastasis-Induced Brain Damage [作者：Fitzgerald, DP; Subramanian, P; Deshpande, M; Graves, C; Gordon, I; Qian, YZ; Snitkovsky, Y; Liewehr, DJ; Steinberg, SM; Paltan-Ortiz, JD; Herman, MM; Camphausen, K; Palmieri, D; Becerra, SP; Steeg, PS,期刊：Cancer research, 页码：144-153 , 文章类型： Article，,卷期：2012年72-1] Brain metastases are a significant cause of morbidity and mortality for patients with cancer, yet preventative and therapeutic options remain an unmet need. The cytokine pigment epithelium-derived factor ( PEDF) is downr... A Combined Array-Based Comparative Genomic Hybridization and Functional Library Screening Approach Identifies mir-30d As an Oncomir in Cancer [作者：Li, N; Kaur, S; Greshock, J; Lassus, H; Zhong, XM; Wang, YL; Leminen, A; Shao, ZJ; Hu, XW; Liang, S; Katsaros, D; Huang, QH; Butzow, R; Weber, BL; Coukos, G; Zhang, L,期刊：Cancer research, 页码：154-164 , 文章类型： Article，,卷期：2012年72-1] Oncomirs are microRNAs (miRNA) that acts as oncogenes or tumor suppressor genes. Efficient identification of oncomirs remains a challenge. Here we report a novel, clinically guided genetic screening approach for the iden... Contrasting Behavior of the p18(INK4c) and p16(INK4a) Tumor Suppressors in Both Replicative and Oncogene-Induced Senescence [作者：Gagrica, S; Brookes, S; Anderton, E; Rowe, J; Peters, G,期刊：Cancer research, 页码：165-175 , 文章类型： Article，,卷期：2012年72-1] The cyclin-dependent kinase (CDK) inhibitors, p18(INK4c) and p16(INK4a), both have the credentials of tumor suppressors in human cancers and mouse models. For p16(INK4a), the underlying rationale is its role in senescenc... Novel Transcriptional Targets of the SRY-HMG Box Transcription Factor SOX4 Link Its Expression to the Development of Small Cell Lung Cancer [作者：Castillo, SD; Matheu, A; Mariani, N; Carretero, J; Lopez-Rios, F; Lovell-Badge, R; Sanchez-Cespedes, M,期刊：Cancer research, 页码：176-186 , 文章类型： Article，,卷期：2012年72-1] The HMG box transcription factor SOX4 involved in neuronal development is amplified and overexpressed in a subset of lung cancers, suggesting that it may be a driver oncogene. In this study, we sought to develop this hyp... Finding a Panacea among Combination Cancer Therapies [作者：Yamaguchi, R; Perkins, G,期刊：Cancer research, 页码：18-23 , 文章类型： Article，,卷期：2012年72-1] Because each cancer is a heterogeneous mix of cancer cells at different stages of development, we are faced with trying to treat many different diseased cells all at once. An authentic approach is to build a genomic and ... Autocrine CSF-1 and CSF-1 Receptor Coexpression Promotes Renal Cell Carcinoma Growth [作者：Menke, J; Kriegsmann, J; Schimanski, CC; Schwartz, MM; Schwarting, A; Kelley, VR,期刊：Cancer research, 页码：187-200 , 文章类型： Article，,卷期：2012年72-1] Renal cell carcinoma is increasing in incidence but the molecular mechanisms regulating its growth remain elusive. Coexpression of the monocytic growth factor colony-stimulating factor (CSF)-1 and its receptor CSF-1R on ... Use of Multifunctional Sigma-2 Receptor Ligand Conjugates to Trigger Cancer-Selective Cell Death Signaling [作者：Spitzer, D; Simon, PO; Kashiwagi, H; Xu, JB; Zeng, CB; Vangveravong, S; Zhou, D; Chang, K; McDunn, JE; Hornick, JR; Goedegebuure, P; Hotchkiss, RS; Mach, RH; Hawkins, WG,期刊：Cancer research, 页码：201-209 , 文章类型： Article，,卷期：2012年72-1] One major challenge in the development of cancer therapeutics is the selective delivery of the drugs to their cellular targets. In the case of pancreatic cancer, the sigma-2 receptor is a unique target that triggers apop... Intermittent Administration of MEK Inhibitor GDC-0973 plus PI3K Inhibitor GDC-0941 Triggers Robust Apoptosis and Tumor Growth Inhibition [作者：Hoeflich, KP; Merchant, M; Orr, C; Chan, J; Den Otter, D; Berry, L; Kasman, I; Koeppen, H; Rice, K; Yang, NY; Engst, S; Johnston, S; Friedman, LS; Belvin, M,期刊：Cancer research, 页码：210-219 , 文章类型： Article，,卷期：2012年72-1] Combinations of MAP/ERK kinase (MEK) and phosphoinositide 3-kinase (PI3K) inhibitors have shown promise in preclinical cancer models, leading to the initiation of clinical trials cotargeting these two key cancer signalin...