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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Responding to Stimuli [作者：MAHAPATRA ANIRBAN,期刊：ACS CHEMICAL BIOLOGY, 页码：233-233 , 文章类型： Editorial Material，,卷期：2009年4-4] Chemical Biology in a Time of Transition [作者：MUIR TOM W,期刊：ACS CHEMICAL BIOLOGY, 页码：241-243 , 文章类型： Editorial Material，,卷期：2009年4-4] Hydrating for Resistance to Radicicol [作者：DUERFELDT ADAM S; BLAGG BRIAN S J,期刊：ACS CHEMICAL BIOLOGY, 页码：245-247 , 文章类型： Article，,卷期：2009年4-4] Resistance to Hsp90 inhibition has become an important concern as several clinical trials are currently in progress for the treatment of cancer. A summary of known mechanisms of resistance to Hsp90 inhibitors is provided... A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450(BM3) [作者：DIETRICH JEFFREY A; YOSHIKUNI YASUO; FISHER KARL J; WOOLARD FRANK X; OCKEY DENISE; MCPHEE DEREK J; RENNINGER NEIL S; CHANG MICHELLE C Y; BAKER DAVID; KEASLING JAY D,期刊：ACS CHEMICAL BIOLOGY, 页码：261-267 , 文章类型： Article，,卷期：2009年4-4] Production of fine chemicals from heterologous pathways in microbial hosts is frequently hindered by insufficient knowledge of the native metabolic pathway and its cognate enzymes; often the pathway is unresolved, and th... Evaluating the Potential for Halogen Bonding in the Oxyanion Hole of Ketosteroid Isomerase Using Unnatural Amino Acid Mutagenesis [作者：KRAUT DANIEL A; CHURCHILL MICHAEL J; DAWSON PHILLIP E; HERSCHLAG DANIEL,期刊：ACS CHEMICAL BIOLOGY, 页码：269-273 , 文章类型： Article，,卷期：2009年4-4] There has recently been an increasing interest in controlling macromolecular conformations and interactions through halogen bonding. Halogen bonds are favorable electrostatic interactions between polarized, electropositi... Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery [作者：LOVE KERRY ROUTENBERG; PANDYA RENUKA K; SPOONER ERIC; PLOEGH HIDDE L,期刊：ACS CHEMICAL BIOLOGY, 页码：275-287 , 文章类型： Article，,卷期：2009年4-4] Protein modification by ubiquitin (Ub) and ubiquitin-like modifiers (Ubl) requires the action of activating (E1), conjugating (E2), and ligating (E3) enzymes and is a key step in the specific destruction of proteins. Deu... Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90 [作者：PRODROMOU CHRISOSTOMOS; NUTTALL JAMES M; MILLSON STEFAN H; ROE S MARK; SIM TIOWSUAN; TAN DOREEN; WORKMAN PAUL; PEARL LAURENCE H; PIPER PETER W,期刊：ACS CHEMICAL BIOLOGY, 页码：289-297 , 文章类型： Article，,卷期：2009年4-4] Heat shock protein 90 (Hsp90) is a promising cancer drug target, as multiple oncogenic proteins are destabilized simultaneously when it loses its activity in tumor cells. Highly selective Hsp90 inhibitors, including the ... Small Molecule Microarrays of RNA-Focused Peptoids Help Identify Inhibitors of a Pathogenic Group I Intron [作者：LABUDA LUCAS P; PUSHECHNIKOV ALEXEI; DISNEY MATTHEW D,期刊：ACS CHEMICAL BIOLOGY, 页码：299-307 , 文章类型： Article，,卷期：2009年4-4] Peptoids that inhibit the group I intron RNA from Candida albicans, an opportunistic pathogen that kilts immunocompromised hosts, have been identified using microarrays. The arrayed peptoid library was constructed using ... An Oxazole-Based Smati-Motecule Stat3 Inhibitor Modulates Stat3 Stability and Processing and Induces Antitumor Cell Effects (vol 2, pg 787, 2007) [作者：SIDDIQUEE KHANDAKER A Z; GUNNING PATRICK T; GLENN MATTHEW; KATT WILLIAM P; ZHANG SHUMIN; SCHROCK CHRISTOPHER; SEBTI SAID M; JOVE RICHARD; HAMILTON ANDREW D; TURKSON JAMES,期刊：ACS CHEMICAL BIOLOGY, 页码：309-309 , 文章类型： Correction，,卷期：2009年4-4] Quantifying Biological Activity in Chemical Terms: A Pharmacology Primer To Describe Drug Effect [作者：KENAKIN TERRY,期刊：ACS CHEMICAL BIOLOGY, 页码：249-260 , 文章类型： Article，,卷期：2009年4-4] Drugs can initiate, inhibit, modulate, or potentiate basal activity in cells to produce physiological effects. The interplay between the fundamental affinity and efficacy of drugs with the functional texture imposed on t...