- In Vitro Folding of K(v)AP, a Voltage-Gated K(+) Channel
[作者：Devaraneni, PK; Devereaux, JJ; Valiyaveetil, FI,期刊：Biochemistry, 页码：10442-10450 , 文章类型： Article，,卷期：2011年50-48]
- In this contribution, we report in vitro folding of the archaebacterial voltage-gated K(+) channel, K(v)AP. We show that in vitro folding of the K(v)AP channel from the extensively unfolded state requires lipid vesicles ...
- Photoinitiated Electron Transfer within the Paracoccus denitrificans Cytochrome bc(1) Complex: Mobility of the Iron-Sulfur Protein Is Modulated by the Occupant of the Q(o) Site
[作者：Havens, J; Castellani, M; Kleinschroth, T; Ludwig, B; Durham, B; Millett, F,期刊：Biochemistry, 页码：10462-10472 , 文章类型： Article，,卷期：2011年50-48]
- Domain rotation of the Rieske iron-sulfur protein (ISP) between the cytochrome (cyt) b and cyt c(1) redox centers plays a key role in the mechanism of the cyt bc(1) complex. Electron transfer within the cyt bc(1) complex...
- Discovery of Amino Acid Motifs for Thrombin Cleavage and Validation Using a Model Substrate
[作者：Ng, NM; Pierce, JD; Webb, GI; Ratnikov, BI; Wijeyewickrema, LC; Duncan, RC; Robertson, AL; Bottomley, SP; Boyd, SE; Pike, RN,期刊：Biochemistry, 页码：10499-10507 , 文章类型： Article，,卷期：2011年50-48]
- Understanding the active site preferences of an enzyme is critical to the design of effective inhibitors and to gaining insights into its mechanisms of action on substrates. While the subsite specificity of thrombin is u...
- Biosynthesis and Antimicrobial Evaluation of Backbone-Cyclized alpha-Defensins
[作者：Garcia, AE; Tai, KP; Puttamadappa, SS; Shekhtman, A; Ouellette, AJ; Camarero, JA,期刊：Biochemistry, 页码：10508-10519 , 文章类型： Article，,卷期：2011年50-48]
- Defensins are antimicrobial peptides that are important in the innate immune defense of mammals. Upon stimulation by bacterial antigens, enteric alpha-defensins are secreted into the intestinal lumen where they have pote...
- Retargeted Clostridial Neurotoxins as Novel Agents for Treating Chronic Diseases
[作者：Yeh, FL; Zhu, YM; Tepp, WH; Johnson, EA; Bertics, PJ; Chapman, ER,期刊：Biochemistry, 页码：10419-10421 , 文章类型： Article，,卷期：2011年50-48]
- Botulinum neurotoxin (BoNT) A and B are used to treat neuropathic disorders; if retargeted, these agents could be used to treat medical conditions that involve secretion from nonneuronal cells. Here, we report novel stra...
- Flexibility, Diversity, and Cooperativity: Pillars of Enzyme Catalysis
[作者：Hammes, GG; Benkovic, SJ; Hammes-Schiffer, S,期刊：Biochemistry, 页码：10422-10430 , 文章类型： Article，,卷期：2011年50-48]
- This brief review discusses our current understanding of the molecular basis of enzyme catalysis. A historical development is presented, beginning with steady state kinetics and progressing through modern fast reaction m...
- Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole-Imidazole Polyamide
[作者：Zhang, Y; Sicot, G; Cui, XH; Vogel, M; Wuertzer, CA; Lezon-Geyda, K; Wheeler, J; Harki, DA; Muzikar, KA; Stolper, DA; Dervan, PB; Perkins, AS,期刊：Biochemistry, 页码：10431-10441 , 文章类型： Article，,卷期：2011年50-48]
- The zinc finger protein EVI1 is causally associated with acute myeloid leukemogenesis, and inhibition of its function with a small molecule therapeutic may provide effective therapy for EVI1-expressing leukemias. In this...
- Characterization of a Fatty Acyl-CoA Reductase from Marinobacter aquaeolei VT8: A Bacterial Enzyme Catalyzing the Reduction of Fatty Acyl-CoA to Fatty Alcohol
[作者：Willis, RM; Wahlen, BD; Seefeldt, LC; Barney, BM,期刊：Biochemistry, 页码：10550-10558 , 文章类型： Article，,卷期：2011年50-48]
- Fatty alcohols are of interest as a renewable feedstock to replace petroleum compounds used as fuels, in cosmetics, and in pharmaceuticals. One biological approach to the production of fatty alcohols involves the sequent...
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