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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共11条记录   Structure of the Apo Form of Bacillus stearothermophilus Phosphofructokinase [作者：Mosser, R; Reddy, MCM; Bruning, JB; Sacchettini, JC; Reinhart, GD,期刊：Biochemistry, 页码：769-775 , 文章类型： Article，,卷期：2012年51-3] The crystal structure of the unliganded form of Bacillus stearothermophilus phosphofructokinase (BsPFK) was determined using molecular replacement to 2.8 angstrom resolution (Protein Data Bank entry 3U39). The apo BsPFK ... Probing Structural Features of Alzheimer's Amyloid-beta Pores in Bilayers Using Site-Specific Amino Acid Substitutions [作者：Capone, R; Jang, H; Kotler, SA; Kagan, BL; Nussinov, R; Lal, R,期刊：Biochemistry, 页码：776-785 , 文章类型： Article，,卷期：2012年51-3] A current hypothesis for the pathology of Alzheimer's disease (AD) proposes that amyloid-beta (A beta) peptides induce uncontrolled, neurotoxic ion flux across cellular membranes. The mechanism of ion flux is not fully u... Investigation of the Catalytic Mechanism of the Hotdog-Fold Enzyme Superfamily Pseudomonas sp Strain CBS3 4-Hydroxybenzoyl-CoA Thioesterase [作者：Zhuang, ZH; Latham, J; Song, F; Zhang, WH; Trujillo, M; Dunaway-Mariano, D,期刊：Biochemistry, 页码：786-794 , 文章类型： Article，,卷期：2012年51-3] The 4-hydroxybenzoyl-CoA (4-HB-CoA) thioesterase from Pseudomonas sp. strain CBS3 catalyzes the final step of the 4-chlorobenzoate degradation pathway, which is the hydrolysis of 4-HB-CoA to coenzyme A (CoA) and 4-hydrox... In Vitro Stoichiometry of Complexes between the Soluble RANK Ligand and the Monoclonal Antibody Denosumab [作者：Arthur, KK; Gabrielson, JP; Hawkins, N; Anafi, D; Wypych, J; Nagi, A; Sullivan, JK; Bondarenko, PV,期刊：Biochemistry, 页码：795-806 , 文章类型： Article，,卷期：2012年51-3] The in vitro binding stoichiometry of denosumab, an IgG2 fully human monoclonal therapeutic antibody, to RANK ligand was determined by multiple complementary size separation techniques with mass measuring detectors, incl... Solution NMR of a 463-Residue Phosphohexomutase: Domain 4 Mobility, Substates, and Phosphoryl Transfer Defect [作者：Sarma, AVS; Anbanandam, A; Kelm, A; Mehra-Chaudhary, R; Wei, YR; Qin, PW; Lee, Y; Berjanskii, MV; Mick, JA; Beamer, LJ; Van Doren, SR,期刊：Biochemistry, 页码：807-819 , 文章类型： Article，,卷期：2012年51-3] Phosphomannomutase/phosphoglucomutase contributes to the infectivity of Pseudomonas aeruginosa, retains and reorients its intermediate by 180 degrees, and rotates domain 4 to close the deep catalytic cleft. Nuclear magne... Factor VIII Light Chain Contains a Binding Site for Factor X That Contributes to the Catalytic Efficiency of Factor Xase [作者：Takeyama, M; Wakabayashi, H; Fay, PJ,期刊：Biochemistry, 页码：820-828 , 文章类型： Article，,卷期：2012年51-3] Factor (F) VIII functions as a cofactor in FXase, markedly accelerating the rate of FIXa-catalyzed activation of FX. Earlier work identified a FX-binding site having mu M affinity within the COOH-terminal region of the F... Solution Structure of CCL21 and Identification of a Putative CCR7 Binding Site [作者：Love, M; Sandberg, JL; Ziarek, JJ; Gerarden, KP; Rode, RR; Jensen, DR; McCaslin, DR; Peterson, FC; Veldkamp, CT,期刊：Biochemistry, 页码：733-735 , 文章类型： Article，,卷期：2012年51-3] CCL21 is a human chemokine that recruits normal immune cells and metastasizing tumor cells to lymph nodes through activation of the G protein-coupled receptor CCR7. The CCL21 structure solved by NMR contains a conserved ... Methylselenocysteine Treatment Leads to Diselenide Formation in Human Cancer Cells: Evidence from X-ray Absorption Spectroscopy Studies [作者：Weekley, CM; Aitken, JB; Musgrave, IF; Harris, HH,期刊：Biochemistry, 页码：736-738 , 文章类型： Article，,卷期：2012年51-3] The selenoamino acids methylselenocysteine (MeSeCys) and selenomethionine (SeMet) have disparate efficacies as anticancer agents. Herein, we use X-ray absorption spectroscopy to determine the chemical form of selenium in... Thermodynamic Dissection of Estrogen Receptor-Promoter Interactions Reveals That Steroid Receptors Differentially Partition Their Self-Association and Promoter Binding Energetics [作者：Moody, AD; Miura, MT; Connaghan, KD; Bain, DL,期刊：Biochemistry, 页码：739-749 , 文章类型： Article，,卷期：2012年51-3] Steroid receptors define a family of ligand-activated transcription factors. Recent work has demonstrated that the receptors regulate distinct but overlapping gene networks, yet the mechanisms by which they do so remain ... Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies [作者：Rea, V; Kolkman, AJ; Vottero, E; Stronks, EJ; Ampt, KAM; Honing, M; Vermeulen, NPE; Wijmenga, SS; Commandeur, JNM,期刊：Biochemistry, 页码：750-760 , 文章类型： Article，,卷期：2012年51-3] Cytochrome P450 BM3 from Bacillus megaterium is a monooxygenase with great potential for biotechnological applications. In this paper, we present engineered drug-metabolizing P450 BM3 mutants as a novel tool for regiosel... Channel-Opening Kinetic Mechanism of Wild-Type GluK1 Kainate Receptors and a C-Terminal Mutant [作者：Han, Y; Wang, CZ; Park, JS; Niu, L,期刊：Biochemistry, 页码：761-768 , 文章类型： Article，,卷期：2012年51-3] GluK1 is a kainate receptor subunit in the ionotropic glutamate receptor family and can form functional channels when expressed, for instance, in HEK-293 cells. However, the channel-opening mechanism of GluK1 is poorly u...