- Rhodopsin Forms a Dimer with Cytoplasmic Helix 8 Contacts in Native Membranes
[作者：Knepp, AM; Periole, X; Marrink, SJ; Sakmar, TP; Huber, T,期刊：Biochemistry, 页码：1819-1821 , 文章类型： Article，,卷期：2012年51-9]
- G protein-coupled receptors form dimers and higher-order oligomers in membranes, but the precise mode of receptor receptor interaction remains unknown. To probe the intradimeric proximity of helix 8 (H8), we conducted ch...
- DNA Damage Products (5 ' R)- and (5 ' S)-8,5 '-Cyclo-2 '-deoxyadenosines as Potential Biomarkers in Human Urine for Atherosclerosis
[作者：Jaruga, P; Rozalski, R; Jawien, A; Migdaski, A; Olinski, R; Dizdaroglu, M,期刊：Biochemistry, 页码：1822-1824 , 文章类型： Article，,卷期：2012年51-9]
- We hypothesized that DNA damage products (5'R)-8,5'-cyclo-2'-deoxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyadenosine (S-cdA) may be well-suited biomarkers of risk and diagnosis for atherosclerosis. We tested this h...
- Designed Cyclic Permutants of HIV-1 gp120: Implications for Envelope Trimer Structure and Immunogen Design
[作者：Saha, P; Bhattacharyya, S; Kesavardhana, S; Miranda, ER; Ali, PSS; Sharma, D; Varadarajan, R,期刊：Biochemistry, 页码：1836-1847 , 文章类型： Article，,卷期：2012年51-9]
- Most HIV-1 broadly neutralizing antibodies are directed against the gp120 subunit of the env surface protein. Native env consists of a trimer of gp120-gp41 heterodimers, and in contrast to monomeric gp120, preferentially...
- Internal Motions and Exchange Processes in Human Ileal Bile Acid Binding Protein As Studied by Backbone N-15 Nuclear Magnetic Resonance Spectroscopy
[作者：Horvath, G; Kiraly, P; Tarkanyi, G; Toke, O,期刊：Biochemistry, 页码：1848-1861 , 文章类型： Article，,卷期：2012年51-9]
- Human deal bile acid binding protein (I-BABP), a member of the family of intracellular lipid binding proteins, is thought to play a role in the enterohepatic circulation of bile salts. Previously, we have shown by stoppe...
- Solution Structure of Kurtoxin: A Gating Modifier Selective for Cav3 Voltage-Gated Ca2+ Channels
[作者：Lee, CW; Bae, C; Lee, J; Ryu, JH; Kim, HH; Kohno, T; Swartz, KJ; Il Kim, J,期刊：Biochemistry, 页码：1862-1873 , 文章类型： Article，,卷期：2012年51-9]
- Kurtoxin is a 63-amino acid polypeptide isolated from the venom of the South African scorpion Parabuthus transvaalicus. It is the first and only peptide ligand known to interact with Cav3 (T-type) voltage-gated Ca2+ chan...
- Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion
[作者：Herbert, AP; Kavanagh, D; Johansson, C; Morgan, HP; Blaum, BS; Hannan, JP; Barlow, PN; Uhrin, D,期刊：Biochemistry, 页码：1874-1884 , 文章类型： Article，,卷期：2012年51-9]
- Numerous complement factor H (FH) mutations predispose patients to atypical hemolytic uremic syndrome (aHUS) and other disorders arising from inadequately regulated complement activation. No unifying structural or mechan...
- Looking over Toxin-K+ Channel Interactions. Clues from the Structural and Functional Characterization of alpha-KTx Toxin Tc32, a Kv1.3 Channel Blocker
[作者：Stehling, EG; Sforca, ML; Zanchin, NIT; Oyama, S; Pignatelli, A; Belluzzi, O; Polverini, E; Corsini, R; Spisni, A; Pertinhez, TA,期刊：Biochemistry, 页码：1885-1894 , 文章类型： Article，,卷期：2012年51-9]
- alpha-KTx toxin Tc32, from the Amazonian scorpion Tityus cambridgei, lacks the dyad motif; including Lys27, characteristic of the family and generally associated with channel blockage. The toxin has been cloned and expre...
- Understanding How the Distal Environment Directs Reactivity in Chlorite Dismutase: Spectroscopy and Reactivity of Arg183 Mutants
[作者：Blanc, B; Mayfield, JA; McDonald, CA; Lukat-Rodgers, GS; Rodgers, KR; DuBois, JL,期刊：Biochemistry, 页码：1895-1910 , 文章类型： Article，,卷期：2012年51-9]
- The chlorite dismutase from Dechloromonas aromatica (DaCld) catalyzes the highly efficient decomposition of chlorite to O-2 and chloride. Spectroscopic, equilibrium thermodynamic, and kinetic measurements have indicated ...
- Myristoylation Exerts Direct and Allosteric Effects on G alpha Conformation and Dynamics in Solution
[作者：Preininger, AM; Kaya, AI; Gilbert, JA; Busenlehner, LS; Armstrong, RN; Hamm, HE,期刊：Biochemistry, 页码：1911-1924 , 文章类型： Article，,卷期：2012年51-9]
- Coupling of heterotrimeric G proteins to activated G protein-coupled receptors results in nucleotide exchange on the G alpha subunit, which in turn decreases its affinity for both G beta gamma and activated receptors. N-...
- Photochemical Nature of Parietopsin
[作者：Sakai, K; Imamoto, Y; Su, CY; Tsukamoto, H; Yamashita, T; Terakita, A; Yau, KW; Shichida, Y,期刊：Biochemistry, 页码：1933-1941 , 文章类型： Article，,卷期：2012年51-9]
- Parietopsin is a nonvisual green light-sensitive opsin closely related to vertebrate visual opsins and was originally identified in lizard parietal eye photoreceptor cells. To obtain insight into the functional diversity...
- Fenpyroximate Binds to the Interface between PSST and 49 kDa Subunits in Mitochondrial NADH-Ubiquinone Oxidoreductase
[作者：Shiraishi, Y; Murai, M; Sakiyama, N; Ifuku, K; Miyoshi, H,期刊：Biochemistry, 页码：1953-1963 , 文章类型： Article，,卷期：2012年51-9]
- Using a photoaffinity labeling technique, Nakamaru-Ogiso et al. demonstrated that fenpyroximate, a strong inhibitor of bovine heart mitochondrial :NADH-ubiquinone oxidoreductase (complex I), binds to the ND5 subunit [Nak...
- Engineering a Potent and Specific Blocker of Voltage-Gated Potassium Channel Kv1.3, a Target for Autoimmune Diseases
[作者：Chen, R; Chung, SH,期刊：Biochemistry, 页码：1976-1982 , 文章类型： Article，,卷期：2012年51-9]
- A polypeptide toxin extracted from scorpion venom, OSK1, is modified such that its potency is drastically enhanced in blocking one class of voltage-gated potassium channels, Kv1.3, which is a pharmacological target for i...
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