- Cooperation between Catalytic and DNA Binding Domains Enhances Thermostability and Supports DNA Synthesis at Higher Temperatures by Thermostable DNA Polymerases
[作者：Pavlov, AR; Pavlova, NV; Kozyavkin, SA; Slesarev, AI,期刊：Biochemistry, 页码：2032-2043 , 文章类型： Article，,卷期：2012年51-10]
- We have previously introduced a general kinetic approach for comparative study of processivity, thermostability, and resistance to inhibitors of DNA polymerases [Pavlov, A. R., et al. (2002) Proc. Natl. Acad. Sci. U.S.A....
- Tyrosine Replacing Tryptophan as an Anchor in GWALP Peptides
[作者：Gleason, NJ; Vostrikov, VV; Greathouse, DV; Grant, CV; Opella, SJ; Koeppe, RE,期刊：Biochemistry, 页码：2044-2053 , 文章类型： Article，,卷期：2012年51-10]
- Synthetic model peptides have proven useful for examining fundamental peptide-lipid interactions. A frequently employed peptide design consists of a hydrophobic core of Leu-Ala residues with polar or aromatic amino acids...
- Deconstruction of Activity-Dependent Covalent Modification of Heme in Human Neutrophil Myeloperoxidase by Multistage Mass Spectrometry (MS4)
[作者：Geoghegan, KF; Varghese, AH; Feng, XD; Bessire, AJ; Conboy, JJ; Ruggeri, RB; Ahn, K; Spath, SN; Filippov, SV; Conrad, SJ; Carpino, PA; Guimaraes, CRW; Vajdos, FF,期刊：Biochemistry, 页码：2065-2077 , 文章类型： Article，,卷期：2012年51-10]
- Myeloperoxidase (MPO) is known to be inactivated and covalently modified by treatment with hydrogen peroxide and agents similar to 3-(2-ethoxypropyl)-2-thioxo-2,3-dihydro-1H-purin-6(9H)-one (1), a 254.08 Da derivative of...
- Hydrodynamic and Functional Analysis of HIV-1 Vif Oligomerization
[作者：Techtmann, SM; Ghirlando, R; Kao, S; Strebel, K; Maynard, EL,期刊：Biochemistry, 页码：2078-2086 , 文章类型： Article，,卷期：2012年51-10]
- HIV-1 Vif is an accessory protein that induces the proteasomal degradation of the host restriction factor, apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G). The N-terminal half of Vif binds t...
- Nitric Oxide Regulation of Cyclic di-GMP Synthesis and Hydrolysis in Shewanella woodyi
[作者：Liu, N; Xu, YM; Hossain, S; Huang, N; Coursolle, D; Gralnick, JA; Boon, EM,期刊：Biochemistry, 页码：2087-2099 , 文章类型： Article，,卷期：2012年51-10]
- Although several reports have documented nitric oxide (NO) regulation of biofilm formation, the molecular basis of this phenomenon is unknown. In many bacteria, an H-NOX (heme-nitric oxide/oxygen-binding) gene is found n...
- Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase by NH125: Evidence of a Common in Vitro Artifact
[作者：Devkota, AK; Tavares, CDJ; Warthaka, M; Abramczyk, O; Marshall, KD; Kaoud, TS; Gorgulu, K; Ozpolat, B; Dalby, KN,期刊：Biochemistry, 页码：2100-2112 , 文章类型： Article，,卷期：2012年51-10]
- Evidence that elongation factor 2 kinase (eEF-2K) has potential as a target for anticancer therapy and possibly for the treatment of depression is emerging. Here the steady-state kinetic mechanism of eEF-2K is presented ...
- Structure-Based Mutagenesis Reveals Critical Residues in the Transferrin Receptor Participating in the Mechanism of pH-Induced Release of Iron from Human Serum Transferrin
[作者：Steere, AN; Chasteen, ND; Miller, BF; Smith, VC; MacGillivray, RTA; Mason, AB,期刊：Biochemistry, 页码：2113-2121 , 文章类型： Article，,卷期：2012年51-10]
- The recent crystal structure of two monoferric human serum transferrin (Fe(N)hTF) molecules bound to the soluble portion of the homodimeric transferrin receptor (sTFR) has provided new details about this binding interact...
- Multivalent Binding and Facilitated Diffusion Account for the Formation of the Grb2-Sos1 Signaling Complex in a Cooperative Manner
[作者：McDonald, CB; Balke, JE; Bhat, V; Mikles, DC; Deegan, BJ; Seldeen, KL; Farooq, A,期刊：Biochemistry, 页码：2122-2135 , 文章类型： Article，,卷期：2012年51-10]
- Despite its key role in driving cellular growth and proliferation through receptor tyrosine kinase (RTK) signaling, the Grb2-Sos1 macromolecular interaction remains poorly understood in mechanistic terms. Herein, using a...
- Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor
[作者：Mercurio, FA; Marasco, D; Pirone, L; Pedone, EM; Pellecchia, M; Leone, M,期刊：Biochemistry, 页码：2136-2145 , 文章类型： Article，,卷期：2012年51-10]
- The EphA2 receptor plays key roles in many physiological and pathological events, including cancer. The process of receptor endocytosis and the consequent degradation have attracted attention as possible means of overcom...
- Role of Coupled Dynamics in the Catalytic Activity of Prokaryotic-like Prolyl-tRNA Synthetases
[作者：Sanford, B; Cao, B; Johnson, JM; Zimmerman, K; Strom, AM; Mueller, RM; Bhattacharyya, S; Musier-Forsyth, K; Hati, S,期刊：Biochemistry, 页码：2146-2156 , 文章类型： Article，,卷期：2012年51-10]
- Prolyl-tRNA synthetases (ProRSs) have been shown to activate both cognate and some noncognate amino acids and attach them to specific tRNA(Pro) substrates. For example, alanine, which is smaller than cognate proline, is ...
- Mechanism of Inhibition for N6022, a First-in-Class Drug Targeting S-Nitrosoglutathione Reductase
[作者：Green, LS; Chun, LE; Patton, AK; Sun, XC; Rosenthal, GJ; Richards, JP,期刊：Biochemistry, 页码：2157-2168 , 文章类型： Article，,卷期：2012年51-10]
- N6022 is a novel, first-in-class drug with potent inhibitory activity against S-nitrosoglutathione reductase (GSNOR), an enzyme important in the metabolism of S-nitrosoglutathione (GSNO) and in the maintenance of nitric ...
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