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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   The C-Terminal Extension of Chloroplast 2-Cys Peroxiredoxin Is Critical for Interaction with ATP [作者：Ferrero, D; Aran, M; Rimmaudo, L; Wolosiuk, RA,期刊：Biochemistry, 页码：2169-2171 , 文章类型： Article，,卷期：2012年51-11] 2-Cys peroxiredoxins (2-Cys Prxs) are ubiquitous enzymes that have been implicated in peroxide-mediated signaling of markedly different processes, such as cancer and photosynthesis. A highly conserved C-terminal extensio... DnaK Prevents Human Insulin Amyloid Fiber Formation on Hydrophobic Surfaces [作者：Ballet, T; Brukert, F; Mangiagalli, P; Bureau, C; Boulange, L; Nault, L; Perret, T; Weidenhaupt, M,期刊：Biochemistry, 页码：2172-2180 , 文章类型： Article，,卷期：2012年51-11] We have developed a multiwell-based protein aggregation assay to study the kinetics of insulin adsorption and aggregation on hydrophobic surfaces and to investigate the molecular mechanisms involved. Protein-surface inte... Targeting Insulin-like Growth Factor I with 10-23 DNAzymes: 2 '-O-Methyl Modifications in the Catalytic Core Enhance mRNA Cleavage [作者：Fokina, AA; Meschaninova, MI; Durfort, T; Venyaminova, AG; Francois, JC,期刊：Biochemistry, 页码：2181-2191 , 文章类型： Article，,卷期：2012年51-11] Insulin-like growth factor I (IGF-I) and its cognate receptor (IGF-1R) contribute to normal cell function and to tumorigenesis. The role of IGF-I signaling in tumor growth has been demonstrated in vivo using nucleic acid... Effects of Non-Nearest Neighbors on the Thermodynamic Stability of RNA GNRA Hairpin Tetra loops [作者：Vanegas, PL; Horwitz, TS; Znosko, BM,期刊：Biochemistry, 页码：2192-2198 , 文章类型： Article，,卷期：2012年51-11] Currently, several models for predicting the secondary structure of RNA exist, one of which is free energy minimization using the Nearest Neighbor Model. This model predicts the lowest-free energy secondary structure fro... Cystic Fibrosis Transmembrane Conductance Regulator: A Molecular Model Defines the Architecture of the Anion Conduction Path and Locates a "Bottleneck" in the Pore [作者：Norimatsu, Y; Ivetac, A; Alexander, C; Kirkham, J; O'Donnell, N; Dawson, DC; Sansom, MSP,期刊：Biochemistry, 页码：2199-2212 , 文章类型： Article，,卷期：2012年51-11] We developed molecular models for the cystic fibrosis transmembrane conductance regulator chloride channel based on the prokaryotic ABC transporter, Sav1866. Here we analyze predicted pore geometry and side-chain orienta... In Vitro Phosphorylation of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase by Src Kinase [作者：Cable, J; Prutzman, K; Gunawardena, HP; Schaller, MD; Chen, X; Campbell, SL,期刊：Biochemistry, 页码：2213-2223 , 文章类型： Article，,卷期：2012年51-11] Focal adhesion kinase (FAK), a key regulator of cell adhesion and migration, is overexpressed in many types of cancer. The C-terminal focal adhesion targeting (FAT) domain of FAK is necessary for proper localization of F... Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts [作者：Camilloni, C; De Simone, A; Vranken, WF; Vendruscolo, M,期刊：Biochemistry, 页码：2224-2231 , 文章类型： Article，,卷期：2012年51-11] One of the major open challenges in structural biology is to achieve effective descriptions of disordered states of proteins. This problem is difficult because these states are conformationally highly heterogeneous and c... Calcium/Calmodulin Stimulates the Autophosphorylation of Elongation Factor 2 Kinase on Thr-348 and Ser-500 To Regulate Its Activity and Calcium Dependence [作者：Tavares, CDJ; O'Brien, JP; Abramczyk, O; Devkota, AK; Shores, KS; Ferguson, SB; Kaoud, TS; Warthaka, M; Marshall, KD; Keller, KM; Zhang, Y; Brodbelt, JS; Ozpolat, B; Dolby, KN,期刊：Biochemistry, 页码：2232-2245 , 文章类型： Article，,卷期：2012年51-11] Eukaryotic elongation factor 2 kinase (eEF-2K) is an atypical protein kinase regulated by Ca2+ and calmodulin (CaM). Its only known substrate is eukaryotic elongation factor 2 (eEF-2), whose phosphorylation by eEF-2K imp... Structural Basis for Calcium and Phosphatidylserine Regulation of Phospholipase C delta 1 [作者：Lomasney, JW; Cheng, HF; Kobayashi, M; King, K,期刊：Biochemistry, 页码：2246-2257 , 文章类型： Article，,卷期：2012年51-11] Many membrane-associated enzymes, including those of the phospholipase C (PLC) superfamily, are regulated by specific interactions with lipids. Previously, we have shown that the C2 domain of PLC delta 1 is required for ... Proteolytic Regulation of the Mitochondrial cAMP-Dependent Protein Kinase [作者：Shell, JR; Lawrence, DS,期刊：Biochemistry, 页码：2258-2264 , 文章类型： Article，,卷期：2012年51-11] The mitochondrial cAMP-dependent protein kinase (PICA) is activatable in a cAMP-independent fashion. The regulatory (R) subunits of the PKA holoenzyme (R2C2), but not the catalytic (C) subunits, suffer proteolysis upon e... Distribution and Properties of the Genes Encoding the Biosynthesis of the Bacterial Cofactor, Pyrroloquinoline Quinone [作者：Shen, YQ; Bonnot, F; Imsand, EM; RoseFigura, JM; Sjolander, K; Klinman, JP,期刊：Biochemistry, 页码：2265-2275 , 文章类型： Article，,卷期：2012年51-11] Pyrroloquinoline quinone (PQQ) is a small, redox active molecule that serves as a cofactor for several bacterial dehydrogenases, introducing pathways for carbon utilization that confer a growth advantage. Early studies h... Purification of Polyhydroxybutyrate Synthase from Its Native Organism, Ralstonia eutropha: Implications for the Initiation and Elongation of Polymer Formation in Vivo [作者：Cho, M; Brigham, CJ; Sinskey, AJ; Stubbe, J,期刊：Biochemistry, 页码：2276-2288 , 文章类型： Article，,卷期：2012年51-11] Class I polyhydroxybutyrate (PHB) synthase (PhaC) from Ralstonia eutropha catalyzes the formation of PHB from (R)-3-hydroxybutyryl-CoA, ultimately resulting in the formation of insoluble granules. Previous mechanistic st... Removal of the C-Terminal Regulatory Domain of alpha-Isopropylmalate Synthase Disrupts Functional Substrate Binding [作者：Huisman, FHA; Koon, N; Bulloch, EMM; Baker, HM; Baker, EN; Squire, CJ; Parker, EJ,期刊：Biochemistry, 页码：2289-2297 , 文章类型： Article，,卷期：2012年51-11] alpha-Isopropylmalate synthase (alpha-IPMS) catalyzes the metal-dependent aldol reaction between alpha-ketoisovalerate (alpha-KIV) and acetyl-coenzyme A (AcCoA) to give alpha-Isopropylmalate (alpha-IPM). This reaction is... Klebsiella aerogenes UreF: Identification of the UreG Binding Site and Role in Enhancing the Fidelity of Urease Activation [作者：Boer, JL; Hausinger, RP,期刊：Biochemistry, 页码：2298-2308 , 文章类型： Article，,卷期：2012年51-11] The Ni-containing active site of Klebsiella aerogenes urease is assembled through the concerted action of the UreD, UreE, UreF, and UreG accessory proteins. UreE functions as a metallochaperone that delivers Ni to a UreD... Weak Interactions between Folate and Osmolytes in Solution [作者：Duff, MR; Grubbs, J; Serpersu, E; Howell, EE,期刊：Biochemistry, 页码：2309-2318 , 文章类型： Article，,卷期：2012年51-11] Previous osmotic stress studies on the role of solvent in two structurally unrelated dihydrofolate reductases (DHFRs) found weaker binding of dihydrofolate (DHF) to either enzyme in the presence of osmolytes. To explain ... OccK Channels from Pseudomonas aeruginosa Exhibit Diverse Single-Channel Electrical Signatures but Conserved Anion Selectivity [作者：Liu, JM; Eren, E; Vijayaraghavan, J; Cheneke, BR; Indic, M; van den Berg, B; Movileanu, L,期刊：Biochemistry, 页码：2319-2330 , 文章类型： Article，,卷期：2012年51-11] Pseudomonas aeruginosa is a Gram-negative bacterium that utilizes substrate-specific outer membrane (OM) proteins for the uptake of small, water-soluble nutrients employed in the growth and function of the cell. In this ...