- Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca(2+)-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet beta-Cells
[作者:Demozay, D; Tsunekawa, S; Briaud, I; Shah, R; Rhodes, CJ,期刊:Diabetes, 页码:2892-2902 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Insulin receptor substrate-2 (IRS-2) plays an essential role in pancreatic islet beta-cells by promoting growth and survival. IRS-2 turnover is rapid in primary beta-cells, but its expression is highly regulate...
- Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes
[作者:Ferraro, A; Socci, C; Stabilini, A; Valle, A; Monti, P; Piemonti, L; Nano, R; Olek, S; Maffi, P; Scavini, M; Secchi, A; Staudacher, C; Bonifacio, E; Battaglia, M,期刊:Diabetes, 页码:2903-2913 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Autoimmune diseases, including type 1 diabetes, are thought to have a Th17-cell bias and/or a T-regulatory cell (Treg) defect. Understanding whether this is a hallmark of patients with type 1 diabetes is a cruc...
- Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell-Directed Type 1 Diabetes Therapies
[作者:Serreze, DV; Chapman, HD; Niens, M; Dunn, R; Kehry, MR; Driver, JP; Haller, M; Wasserfal, C; Atkinson, MA,期刊:Diabetes, 页码:2914-2921 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Consistent with studies in NOD mice, early clinical trials addressing whether depletion of B cells by the Rituximab CD20-specific antibody provides an effective means for type 1 diabetes reversal have produced ...
- Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice
[作者:Oeser, JK; Parekh, VV; Wang, YD; Jegadeesh, NK; Sarkar, SA; Wong, R; Lee, CE; Pound, LD; Hutton, JC; Van Kaer, L; O'Brien, RM,期刊:Diabetes, 页码:2922-2927 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), now known as G6PC2, is a major target of autoreactive T cells implicated in the pathogenesis of type 1 diabetes in both mice and hu...
- Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes
[作者:Li, Y; Ma, J; Zhu, HQ; Singh, M; Hill, D; Greer, PA; Arnold, JM; Abel, ED; Peng, TQ,期刊:Diabetes, 页码:2985-2994 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Recently we have shown that calpain-1 activation contributes to cardiomyocyte apoptosis induced by hyperglycemia. This study was undertaken to investigate whether targeted disruption of calpain would reduce myo...
- Intervention With an Erythropoietin-Derived Peptide Protects Against Neuroglial and Vascular Degeneration During Diabetic Retinopathy
[作者:McVicar, CM; Hamilton, R; Colhoun, LM; Gardiner, TA; Brines, M; Cerami, A; Stitt, AW,期刊:Diabetes, 页码:2995-3005 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Erythropoietin (EPO) may be protective for early stage diabetic retinopathy, although there are concerns that it could exacerbate retinal angiogenesis and thrombosis. A peptide based on the EPO helix-B domain (...
- Prospectively Determined Impact of Type 1 Diabetes on Brain Volume During Development
[作者:Perantie, DC; Koller, JM; Weaver, PM; Lugar, HM; Black, KJ; White, NH; Hershey, T,期刊:Diabetes, 页码:3006-3014 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE The impact of type 1 diabetes mellitus (T1DM) on the developing central nervous system is not well understood. Cross-sectional, retrospective studies suggest that exposure to glycemic extremes during developmen...
- Arginase-2 Mediates Diabetic Renal Injury
[作者:Morris, SM; Gao, T; Cooper, TK; Kepka-Lenhart, D; Awad, AS,期刊:Diabetes, 页码:3015-3022 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-To determine 1) whether renal arginase activity or expression is increased in diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN). RESEARCH DESIGN AND METHODS-The impact of...
- A Novel Cellular Defect in Diabetes Membrane Repair Failure
[作者:Howard, AC; McNeil, AK; Xiong, F; Xiong, WC; McNeil, PL,期刊:Diabetes, 页码:3034-3043 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Skeletal muscle myopathy is a common diabetes complication. One possible cause of myopathy is myocyte failure to repair contraction-generated plasma membrane injuries. Here, we test the hypothesis that diabetes...
- APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice
[作者:Wang, Y; Cheng, KKY; Lam, KSL; Wu, DH; Wang, Y; Huang, Y; Vanhoutte, PM; Sweeney, G; Li, YM; Xu, AM,期刊:Diabetes, 页码:3044-3054 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Insulin stimulates both nitric oxide (NO)-dependent vasodilation and endothelin-1 (ET-1)-dependent vasoconstriction. However, the cellular mechanisms that control the dual vascular effects of insulin remain unc...
- Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy
[作者:Zheng, HT; Whitman, SA; Wu, W; Wondrak, GT; Wong, PK; Fang, DY; Zhang, DD,期刊:Diabetes, 页码:3055-3066 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabe...
- C-peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277 An Exploratory Study
[作者:Buzzetti, R; Cernea, S; Petrone, A; Capizzi, M; Spoletini, M; Zampetti, S; Guglielmi, C; Venditti, C; Pozzilli, P,期刊:Diabetes, 页码:3067-3072 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-To investigate whether lower risk HLA class II genotypes would influence the efficacy of DiaPep277 therapy in protecting beta-cell function evaluated by C-peptide secretion in recent-onset type I diabetic subje...
- Genetic Examination of SETD7 and SUV39H1/H2 Methyltransferases and the Risk of Diabetes Complications in Patients With Type 1 Diabetes
[作者:Syreeni, A; El-Osta, A; Forsblom, C; Sandholm, N; Parkkonen, M; Tarnow, L; Parving, HH; McKnight, AJ; Maxwell, AP; Cooper, ME; Groop, PH,期刊:Diabetes, 页码:3073-3080 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-Hyperglycemia plays a pivotal role in the development and progression of vascular complications, which are the major sources of morbidity and mortality in diabetes. Furthermore, these vascular complications oft...
- FUT2 Nonsecretor Status Links Type 1 Diabetes Susceptibility and Resistance to Infection
[作者:Smyth, DJ; Cooper, JD; Howson, JMM; Clarke, P; Downes, K; Mistry, T; Stevens, H; Walker, NM; Todd, JA,期刊:Diabetes, 页码:3081-3084 , 文章类型: Article,,卷期:2011年60-11]
- OBJECTIVE-FUT2 encodes the alpha(1,2) fucosyltransferase that determines blood group secretor status. Homozygotes (A/A) for the common nonsense mutation rs601338A>G (W143X) are non-secretors and are unable to express his...
- Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the beta-cell sulfonylurea receptor SUR1 (vol 60, pg 1797, 2011)
[作者:MacMullen, CM; Zhou, Q; Snider, KE; Tewson, PH; Becker, SA; Aziz, AR; Ganguly, A; Shyng, SL; Stanley, CA,期刊:Diabetes, 页码:3097-3097 , 文章类型: Correction,,卷期:2011年60-11]
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