- Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1
[作者:Prasad, A; Wallace, SS; Pederson, DS,期刊:Molecular and Cellular Biology, 页码:8442-8453 , 文章类型: Article,,卷期:2007年27-24]
- Oxidative lesions account for much of the spontaneously occurring DNA damage in normal cells and, left unrepaired, can be mutagenic or cytotoxic. We have investigated the capacity of purified human enzymes to initiate th...
- Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: Disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/connective tissue growth factor angiogenic inhibitory complexes by MMP-2 proteolysis
[作者:Dean, RA; Butler, GS; Hamma-Kourbali, Y; Delbe, J; Brigstock, DR; Courty, J; Overall, CM,期刊:Molecular and Cellular Biology, 页码:8454-8465 , 文章类型: Article,,卷期:2007年27-24]
- Matrix metalloproteinases (MMPs) exert both pro- and antiangiogenic functions by the release of cytokines or proteolytically generated angiogenic inhibitors from extracellular matrix and basement membrane remodeling. In ...
- Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells
[作者:Kang, TH; Park, DY; Choi, YH; Kim, KJ; Yoon, HS; Kim, KT,期刊:Molecular and Cellular Biology, 页码:8533-8546 , 文章类型: Article,,卷期:2007年27-24]
- Mitotic chromatin condensation is essential for cell division in eukaryotes. Posttranslational modification of the N-terminal tail of histone proteins, particularly by phosphorylation by mitotic histone kinases, may faci...
- Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse
[作者:Giurisato, E; Cella, M; Takai, T; Kurosaki, T; Feng, Y; Longmore, GD; Colonna, M; Shaw, AS,期刊:Molecular and Cellular Biology, 页码:8583-8599 , 文章类型: Article,,卷期:2007年27-24]
- The receptor NKG2D allows natural killer (NK) cells to detect virally infected, stressed, and tumor cells. In human cells, NKG2D signaling is mediated through the associated DAP10 adapter. Here we show that engagement of...
- A divergent Sm fold in EDC3 proteins mediates DCPI binding and P-body targeting
[作者:Tritschler, F; Eulalio, A; Truffault, V; Hartmann, MD; Helms, S; Schmidt, S; Coles, M; Izaurralde, E; Weichenrieder, O,期刊:Molecular and Cellular Biology, 页码:8600-8611 , 文章类型: Article,,卷期:2007年27-24]
- Members of the (L)Sm (Sm and Sm-like) protein family are found across all kingdoms of life and play crucial roles in RNA metabolism. The P-body component EDC3 (enhancer of decapping 3) is a divergent member of this famil...
- c-Cbl-mediated regulation of LAT-nucleated signaling complexes
[作者:Balagopalan, L; Barr, VA; Sommers, CL; Barda-Saad, M; Goyal, A; Isakowitz, MS; Samelson, LE,期刊:Molecular and Cellular Biology, 页码:8622-8636 , 文章类型: Article,,卷期:2007年27-24]
- The engagement of the T-cell receptor (TCR) causes the rapid recruitment of multiple signaling molecules into clusters with the TCR. Upon receptor activation, the adapters LAT and SLP-76, visualized as chimeric proteins ...
- Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis
[作者:Gao, YS; Hubbert, CC; Lu, J; Lee, YS; Lee, JY; Yao, TP,期刊:Molecular and Cellular Biology, 页码:8637-8647 , 文章类型: Article,,卷期:2007年27-24]
- Histone deacetylase 6 (HDAC6) is a cytoplasmic deacetylase that uniquely catalyzes alpha-tubulin deacetylation and promotes cell motility. However, the mechanism underlying HDAC6-dependent cell migration and the role for...
- Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling
[作者:Riggs, DL; Cox, MB; Tardif, HL; Hessling, M; Buchner, J; Smith, DF,期刊:Molecular and Cellular Biology, 页码:8658-8669 , 文章类型: Article,,卷期:2007年27-24]
- Hormone-dependent transactivation by several of the steroid hormone receptors is potentiated by the Hsp90-associated cochaperone FKBP52, although not by the closely related FKBP51. Here we analyze the mechanisms of poten...
- The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity
[作者:Garcia-Mata, R; Dubash, AD; Sharek, L; Carr, HS; Frost, JA; Burridge, K,期刊:Molecular and Cellular Biology, 页码:8683-8697 , 文章类型: Article,,卷期:2007年27-24]
- Net1 is a RhoA-specific guanine nucleotide exchange factor which localizes to the nucleus at steady state. A deletion in its N terminus redistributes the protein to the cytosol, where it activates RhoA and can promote tr...
- UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: A basis for the regulation of FANCD2 monoubiquitination
[作者:Alpi, A; Langevin, F; Mosedale, G; Machida, YJ; Dutta, A; Patel, KJ,期刊:Molecular and Cellular Biology, 页码:8421-8430 , 文章类型: Article,,卷期:2007年27-24]
- The Fanconi anemia (FA) nuclear core complex and the E2 ubiquitin-conjugating enzyme UBE2T are required for the S phase and DNA damage-restricted monoubiquitination of FANCD2. This constitutes a key step in the FA tumor ...
|