- Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
[作者：Badoux, XC; Keating, MJ; Wen, SJ; Lee, BN; Sivina, M; Reuben, J; Wierda, WG; O'Brien, SM; Faderl, S; Kornblau, SM; Burger, JA; Ferrajoli, A,期刊：Blood, 页码：3489-3498 , 文章类型： Article，,卷期：2011年118-13]
- The best initial therapy for elderly patients with chronic lymphocytic leukemia (CLL) has not yet been defined. We investigated the activity of lenalidomide as initial therapy for elderly patients with CLL. Sixty patient...
- Improved outcome with rituximab in patients with HIV-associated multicentric Castleman disease
[作者：Hoffmann, C; Schmid, H; Muller, M; Teutsch, C; van Lunzen, J; Esser, S; Wolf, T; Wyen, C; Sabranski, M; Horst, HA; Reuter, S; Vogel, M; Jager, H; Bogner, J; Arasteh, K,期刊：Blood, 页码：3499-3503 , 文章类型： Article，,卷期：2011年118-13]
- Although HIV-associated multicentric Castleman disease (HIV-MCD) is not classified as an AIDS-defining illness, mortality is high and progression to lymphoma occurs frequently. At present, there is no widely accepted rec...
- The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor
[作者：Ma, PL; Mali, RS; Munugalavadla, V; Krishnan, S; Ramdas, B; Sims, E; Martin, H; Ghosh, J; Li, S; Chan, RJ; Krystal, G; Craig, AW; Takemoto, C; Kapur, R,期刊：Blood, 页码：3459-3469 , 文章类型： Article，,卷期：2011年118-13]
- Mast cell maturation is poorly understood. We show that enhanced PI3K activation results in accelerated maturation of mast cells by inducing the expression of microphthalmia transcription factor (Mitf). Conversely, loss ...
- CD38 and chronic lymphocytic leukemia: a decade later
[作者：Malavasi, F; Deaglio, S; Damle, R; Cutrona, G; Ferrarini, M; Chiorazzi, N,期刊：Blood, 页码：3470-3478 , 文章类型： Review，,卷期：2011年118-13]
- This review highlights a decade of investigations into the role of CD38 in CLL. CD38 is accepted as a dependable marker of unfavorable prognosis and as an indicator of activation and proliferation of cells when tested. L...
- How I treat thalassemia
[作者：Rachmilewitz, EA; Giardina, PJ,期刊：Blood, 页码：3479-3488 , 文章类型： Article，,卷期：2011年118-13]
- The purpose of this article is to set forth our approach to diagnosing and managing the thalassemias, including beta-thalassemia intermedia and beta-thalassemia major. The article begins by briefly describing recent adva...
- High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation
[作者：Gokbuget, N; Basara, N; Baurmann, H; Beck, J; Bruggemann, M; Diedrich, H; Guldenzoph, B; Hartung, G; Horst, HA; Huttmann, A; Kobbe, G; Naumann, R; Ratei, R; Reichle, A; Serve, H; Stelljes, M; Viardot, A; Wattad, M; Hoelzer, D,期刊：Blood, 页码：3504-3511 , 文章类型： Article，,卷期：2011年118-13]
- Nelarabine, a purine analog with T-cell specific action, has been approved for relapsed/refractory T-cell acute lymphoblastic leukemia/lymphoma (ALL/LBL). This is a report of a single-arm phase 2 study conducted in adult...
- Pharmacogenomics of bortezomib test-dosing identifies hyperexpression of proteasome genes, especially PSMD4, as novel high-risk feature in myeloma treated with Total Therapy 3
[作者：Shaughnessy, JD; Qu, PP; Usmani, S; Heuck, CJ; Zhang, Q; Zhou, YM; Tian, EM; Hanamura, I; van Rhee, F; Anaissie, E; Epstein, J; Nair, B; Stephens, O; Williams, R; Waheed, S; Alsayed, Y; Crowley, J; Barlogie, B,期刊：Blood, 页码：3512-3524 , 文章类型： Article，,卷期：2011年118-13]
- Gene expression profiling (GEP) of purified plasma cells 48 hours after thalidomide and dexamethasone test doses showed these agents' mechanisms of action and provided prognostic information for untreated myeloma patient...
- Incidence of therapy-related myeloid neoplasia after initial therapy for chronic lymphocytic leukemia with fludarabine-cyclophosphamide versus fludarabine: long-term follow-up of US Intergroup Study E2997
[作者：Smith, MR; Neuberg, D; Flinn, IW; Grever, MR; Lazarus, HM; Rowe, JM; Dewald, G; Bennett, JM; Paietta, EM; Byrd, JC; Hussein, MA; Appelbaum, FR; Larson, RA; Litzow, MR; Tallman, MS,期刊：Blood, 页码：3525-3527 , 文章类型： Article，,卷期：2011年118-13]
- Chemotherapy-related myeloid neoplasia (t-MN) is a significant late toxicity concern after cancer therapy. In the randomized intergroup phase 3 E2997 trial, initial therapy of chronic lymphocytic leukemia with fludarabin...
- CD3 limits the efficacy of TCR gene therapy in vivo
[作者：Ahmadi, M; King, JW; Xue, SA; Voisine, C; Holler, A; Wright, GP; Waxman, J; Morris, E; Stauss, HJ,期刊：Blood, 页码：3528-3537 , 文章类型： Article，,卷期：2011年118-13]
- The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR alpha/beta heterodimer. We tested whether endogenous CD3 chains are rate-limiting for TCR exp...
- Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells
[作者：Wehrens, EJ; Mijnheer, G; Duurland, CL; Klein, M; Meerding, J; van Loosdregt, J; de Jager, W; Sawitzki, B; Coffer, PJ; Vastert, B; Prakken, BJ; van Wijk, F,期刊：Blood, 页码：3538-3548 , 文章类型： Article，,卷期：2011年118-13]
- During the last decade research has focused on the application of FOXP3(+) regulatory T cells (Tregs) in the treatment of autoimmune disease. However, thorough functional characterization of these cells in patients with ...
- CCL18 differentiates dendritic cells in tolerogenic cells able to prime regulatory T cells in healthy subjects
[作者：Azzaoui, I; Yahia, SA; Chang, Y; Vorng, H; Morales, O; Fan, Y; Delhem, N; Ple, C; Tonnel, AB; Wallaert, B; Tsicopoulos, A,期刊：Blood, 页码：3549-3558 , 文章类型： Article，,卷期：2011年118-13]
- The aim of this study was to evaluate the nonchemotactic function of CCL18 on human dendritic cells (DCs). In different protocols of DC differentiation, CCL18 was highly produced, suggesting that it may constitute a mand...
- DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation
[作者：Shaknovich, R; Cerchietti, L; Tsikitas, L; Kormaksson, M; De, S; Figueroa, ME; Ballon, G; Yang, SN; Weinhold, N; Reimers, M; Clozel, T; Luttrop, K; Ekstrom, TJ; Frank, J; Vasanthakumar, A; Godley, LA; Michor, F; Elemento, O; Melnick, A,期刊：Blood, 页码：3559-3569 , 文章类型： Article，,卷期：2011年118-13]
- The phenotype of germinal center (GC) B cells includes the unique ability to tolerate rapid proliferation and the mutagenic actions of activation induced cytosine deaminase (AICDA). Given the importance of epigenetic pat...
- Development of thymic NK cells from double negative 1 thymocyte precursors
[作者：Vargas, CL; Poursine-Laurent, J; Yang, LP; Yokoyama, WM,期刊：Blood, 页码：3570-3578 , 文章类型： Article，,卷期：2011年118-13]
- The differentiation of natural killer (NK) cells and a subpopulation of NK cells which requires an intact thymus, that is, thymic NK cells, is poorly understood. Previous in vitro studies indicate that double negative (C...
- An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737
[作者：Al-Harbi, S; Hill, BT; Mazumder, S; Singh, K; DeVecchio, J; Choudhary, G; Rybicki, LA; Kalaycio, M; Maciejewski, JP; Houghton, JA; Almasan, A,期刊：Blood, 页码：3579-3590 , 文章类型： Article，,卷期：2011年118-13]
- The antiapoptotic BCL-2 proteins regulate lymphocyte survival and are over-expressed in lymphoid malignancies, including chronic lymphocytic leukemia. The small molecule inhibitor ABT-737 binds with high affinity to BCL-...
- Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation
[作者：Hilchey, SP; Rosenberg, AF; Hyrien, O; Secor-Socha, S; Cochran, MR; Brady, MT; Wang, JCE; Sanz, I; Burack, WR; Quataert, SA; Bernstein, SH,期刊：Blood, 页码：3591-3602 , 文章类型： Article，,卷期：2011年118-13]
- The follicular lymphoma (FL) T-cell microenvironment plays a critical role in the biology of this disease. We therefore determined the lineage, differentiation state, and functional potential of FL-infiltrating CD4(+) T-...
- The phosphoinositide 3 '-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
[作者：Hoellenriegel, J; Meadows, SA; Sivina, M; Wierda, WG; Kantarjian, H; Keating, MJ; Giese, N; O'Brien, S; Yu, A; Miller, LL; Lannutti, BJ; Burger, JA,期刊：Blood, 页码：3603-3612 , 文章类型： Article，,卷期：2011年118-13]
- In lymphocytes, the phosphoinositide 3'-kinase (PI3K) isoform p110 delta (PI3K delta) transmits signals from surface receptors, including the B-cell receptor (BCR). CAL-101, a selective inhibitor of PI3K delta, displays ...
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