- Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages
[作者:Yuan, KF; Huang, CH; Fox, J; Laturnus, D; Carlson, E; Zhang, BJ; Yin, Q; Gao, HW; Wu, M,期刊:Journal of cell science, 页码:507-515 , 文章类型: Article,,卷期:2012年125-2]
- Intracellular bacteria have been shown to cause autophagy, which impacts infectious outcomes, whereas extracellular bacteria have not been reported to activate autophagy. Here, we demonstrate that Pseudontonas aeruginosa...
- Mammalian erythroblast enucleation requires PI3K-dependent cell polarization
[作者:Wang, JX; Ramirez, T; Ji, P; Jayapal, SR; Lodish, HF; Murata-Hori, M,期刊:Journal of cell science, 页码:340-349 , 文章类型: Article,,卷期:2012年125-2]
- Enucleation, the final step in terminal differentiation of mammalian red blood cells, is an essential process in which the nucleus surrounded by the plasma membrane is budded off from the erythroblast to form a reticuloc...
- Mob1: defining cell polarity for proper cell division
[作者:Tavares, A; Goncalves, J; Florindo, C; Tavares, AA; Soares, H,期刊:Journal of cell science, 页码:516-527 , 文章类型: Article,,卷期:2012年125-2]
- Mob1 is a component of both the mitotic exit network and Hippo pathway, being required for cytokinesis, control of cell proliferation and apoptosis. Cell division accuracy is crucial in maintaining cell ploidy and genomi...
- Cellular functions of the DUBs
[作者:Clague, MJ; Coulson, JM; Urbe, S,期刊:Journal of cell science, 页码:277-286 , 文章类型: Article,,卷期:2012年125-2]
- Ubiquitylation is a reversible post-translational modification that has emerged as a key regulator of most complex cellular processes. It may rival phosphorylation in scope and exceed it in complexity. The dynamic nature...
- Neuropilin-2 regulates alpha 6 beta 1 integrin in the formation of focal adhesions and signaling
[作者:Goel, HL; Pursell, B; Standley, C; Fogarty, K; Mercurio, AM,期刊:Journal of cell science, 页码:497-506 , 文章类型: Article,,卷期:2012年125-2]
- The neuropilins (NRPs) contribute to the function of cancer cells in their capacity as VEGF receptors. Given that NRP2 is induced in breast cancer and correlates with aggressive disease, we examined the role of NRP2 in r...
- Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation
[作者:Gascue, C; Tan, PL; Cardenas-Rodriguez, M; Libisch, G; Fernandez-Calero, T; Liu, YFP; Astrada, S; Robello, C; Naya, H; Katsanis, N; Badano, JL,期刊:Journal of cell science, 页码:362-375 , 文章类型: Article,,卷期:2012年125-2]
- Primary cilia are conserved organelles that play crucial roles as mechano- and chemosensors, as well as transducing signaling cascades. Consequently, ciliary dysfunction results in a broad range of phenotypes: the ciliop...
- Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish
[作者:Volkers, M; Dolatabadi, N; Gude, N; Most, P; Sussman, MA; Hassel, D,期刊:Journal of cell science, 页码:287-294 , 文章类型: Article,,卷期:2012年125-2]
- Mutations in the store-operated Ca2+ entry pore protein ORAI1 have been reported to cause myopathies in human patients but the mechanism involved is not known. Cardiomyocytes express ORAI1 but its role in heart function ...
- Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells
[作者:Liu, J; Xu, K; Chase, M; Ji, Y; Logan, JK; Buchsbaum, RJ,期刊:Journal of cell science, 页码:376-386 , 文章类型: Article,,卷期:2012年125-2]
- The tumor microenvironment undergoes changes concurrent with neoplastic progression. Cancer incidence increases with aging and is associated with tissue accumulation of senescent cells. Senescent fibroblasts are thought ...
- Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages
[作者:Bartolome-Martin, D; Ramirez-Franco, J; Castro, E; Sanchez-Prieto, J; Torres, M,期刊:Journal of cell science, 页码:422-434 , 文章类型: Article,,卷期:2012年125-2]
- Following the exocytosis of neurotransmitter-containing synaptic vesicles, endocytosis is fundamental to re-establishing conditions for synaptic transmission. As there are distinct endocytotic pathways that each differ i...
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