- Controlled release of cell-permeable gene complex from poly(L-lactide) scaffold for enhanced stem cell tissue engineering
[作者:Jung, MR; Shim, IK; Kim, ES; Park, YJ; Yang, YI; Lee, SK; Lee, SJ,期刊:Journal of controlled release, 页码:294-302 , 文章类型: Article,,卷期:2011年152-2]
- The use of tissue engineering to deliver genes to stem cells has been impeded by low transfection efficiency of the inserted gene and poor retention at the target site. Herein, we describe the use of non-viral gene trans...
- Neurotherapeutic applications of nanoparticles in Alzheimer's disease
[作者:Sahni, JK; Doggui, S; Ali, J; Baboota, S; Dao, L; Ramassamy, C,期刊:Journal of controlled release, 页码:208-231 , 文章类型: Review,,卷期:2011年152-2]
- A rapid increase in incidence of neurodegenerative disorders has been observed with the aging of the population. Alzheimer's disease (AD) is the most common neurodegenerative disorder among the elderly. It is characteriz...
- Modified Tat peptide with cationic lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis
[作者:Yamano, S; Dai, JS; Yuvienco, C; Khapli, S; Moursi, AM; Montclare, JK,期刊:Journal of controlled release, 页码:278-285 , 文章类型: Article,,卷期:2011年152-2]
- The HIV-1 Tat peptide has been successfully used for intracellular gene delivery. Likewise, various lipid-based methods have shown increased endocytosis and can influence endosomal escape. This study combines the favorab...
- Bone reservoir: Injectable hyaluronic acid hydrogel for minimal invasive bone augmentation
[作者:Martinez-Sanz, E; Ossipov, DA; Hilborn, J; Larsson, S; Jonsson, KB; Varghese, OP,期刊:Journal of controlled release, 页码:232-240 , 文章类型: Article,,卷期:2011年152-2]
- A strategy has been designed to develop hyaluronic acid (HA) hydrogel for in vivo bone augmentation using minimal invasive technique. A mild synthetic procedure was developed to prepare aldehyde modified HA by incorporat...
- Intranasal immunization with poly(gamma-glutamic acid) nanoparticles entrapping antigenic proteins can induce potent tumor immunity
[作者:Matsuo, K; Koizumi, H; Akashi, M; Nakagawa, S; Fujita, T; Yamamoto, A; Okada, N,期刊:Journal of controlled release, 页码:310-316 , 文章类型: Article,,卷期:2011年152-2]
- We previously reported strong induction of ovalbumin (OVA)-specific tumor immunity in mice injected subcutaneously with OVA-entrapping nanoparticles comprising amphiphilic poly(gamma-glutamic acid) (OVA/gamma-PGA NPs). I...
- Enhanced cytosolic drug delivery using fully biodegradable poly(amino oxalate) particles
[作者:Seong, K; Seo, H; Ahn, W; Yoo, D; Cho, S; Khang, G; Lee, D,期刊:Journal of controlled release, 页码:257-263 , 文章类型: Article,,卷期:2011年152-2]
- Rapid endosomal escape of drug carriers is crucial to enhancing the efficacy of their macromolecular payload, especially proteins that are susceptible to lysosomal degradation. In this paper, we report poly(amino oxalate...
- Highly efficient nanomedicines assembled via polymer-drug multiple interactions: Tissue-selective delivery carriers
[作者:Zhu, YX; Che, L; He, HM; Jia, Y; Zhang, JX; Li, XH,期刊:Journal of controlled release, 页码:317-324 , 文章类型: Article,,卷期:2011年152-2]
- This study presents the construction and evaluation of highly efficient nanomedicines via self-assembly directed by multiple non-covalent interactions between carrier polymer and cargo molecules, including hydrophobic, h...
- Selective gene transfection of individual cells in vitro with plasmonic nanobubbles
[作者:Lukianova-Hleb, EY; Samaniego, AP; Wen, JG; Metelitsa, LS; Chang, CC; Lapotko, DO,期刊:Journal of controlled release, 页码:286-293 , 文章类型: Article,,卷期:2011年152-2]
- Gene delivery and transfection of eukaryotic cells are widely used for research and for developing gene cell therapy. However, the existing methods lack selectivity, efficacy and safety when heterogeneous cell systems mu...
- Kinetics of reciprocating drug delivery to the inner ear
[作者:Pararas, EEL; Chen, ZQ; Fiering, J; Mescher, MJ; Kim, ES; McKenna, MJ; Kujawa, SG; Borenstein, JT; Sewell, WF,期刊:Journal of controlled release, 页码:270-277 , 文章类型: Article,,卷期:2011年152-2]
- Reciprocating drug delivery is a means of delivering soluble drugs directly to closed fluid spaces in the body via a single cannula without an accompanying fluid volume change. It is ideally suited for drug delivery into...
- Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker
[作者:Kaminskas, LM; Kelly, BD; McLeod, VM; Sberna, G; Owen, DJ; Boyd, BJ; Porter, CJH,期刊:Journal of controlled release, 页码:241-248 , 文章类型: Article,,卷期:2011年152-2]
- Polylysine dendrimers have potential as biodegradable vectors for the delivery of cytotoxic drugs to solid tumours. Here, the cytotoxicity, drug release and tumour targeting properties of Generation 5 PEGylated polylysin...
- Osmotic capsules: A universal oral, controlled-release drug delivery dosage form
[作者:Waterman, KC; Goeken, GS; Konagurthu, S; Likar, MD; MacDonald, BC; Mahajan, N; Swaminathan, V,期刊:Journal of controlled release, 页码:264-269 , 文章类型: Article,,卷期:2011年152-2]
- An osmotic, oral, controlled-release capsule is described. This capsule provides drug delivery at fixed delivery rates (T-80% = 6 or 14 h) independent of drug properties (e.g., solubility) or drug loading, thereby allowi...
- Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery
[作者:Geers, B; Lentacker, I; Sanders, NN; Demeester, J; Meairs, S; De Smedt, SC,期刊:Journal of controlled release, 页码:249-256 , 文章类型: Article,,卷期:2011年152-2]
- Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simpl...
- Topical and intravitreous administration of cationic nanoemulsions to deliver antisense oligonucleotides directed towards VEGF KDR receptors to the eye (vol 145, pg 297, 2010)
[作者:Hagigit, T; Abdulrazik, M; Orucov, F; Valamanesh, F; Lambert, M; Lambert, G; Behar-Cohen, F; Benita, S,期刊:Journal of controlled release, 页码:325-325 , 文章类型: Correction,,卷期:2011年152-2]
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