- Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders
[作者:Castillo, J; Milani, C; Mendez-Allwood, D,期刊:Expert opinion on investigational drugs, 页码:491-500 , 文章类型: Article,,卷期:2009年18-4]
- Background: Lymphoproliferative and autoimmune disorders share monoclonal dysregulation and survival advantage of B-lymphocytes. Thus, therapies directed towards eliminating B-cells will play an important role as CD20 is...
- DCVax (R)-Brain and DC vaccines in the treatment of GBM
[作者:Wheeler, CJ; Black, KL,期刊:Expert opinion on investigational drugs, 页码:509-519 , 文章类型: Article,,卷期:2009年18-4]
- Background: DCVax (R)-Brain (Northwest Biotherapeutics, Inc., Bethesda, MD, USA) is a personalized treatment for brain tumors. Its approach of administering autologous tumor antigen-bearing dendritic cells (DCs) has garn...
- The role of telavancin in the treatment of MRSA infections in hospital
[作者:Bassetti, M; Mikulska, M; Righi, E; Nicolini, L; Viscoli, C,期刊:Expert opinion on investigational drugs, 页码:521-529 , 文章类型: Article,,卷期:2009年18-4]
- Background: Serious infections caused by Gram-positive bacteria, particularly multi-drug resistant, are an important cause of morbidity and mortality in patients admitted to intensive care units. Thus, new antibiotics co...
- Aurora kinase inhibitors in preclinical and clinical testing
[作者:Cheung, CHA; Coumar, MS; Hsieh, HP; Chang, JY,期刊:Expert opinion on investigational drugs, 页码:379-398 , 文章类型: Review,,卷期:2009年18-4]
- Background: Mitosis is a key step in the cell cycle governing the distribution of genetic material to the daughter cells. Any aberration in this process could lead to genomic instability. Aurora A, B and C, are members o...
- Flavonoids, phenoxodiol, and a novel agent, triphendiol, for the treatment of pancreaticobiliary cancers
[作者:Saif, MW; Tytler, E; Lansigan, F; Brown, DM; Husband, AJ,期刊:Expert opinion on investigational drugs, 页码:469-479 , 文章类型: Review,,卷期:2009年18-4]
- Flavonoids, in particular the isoflavones, are naturally occurring compounds found in soy and textured vegetables that have antiproliferative effects on a variety of cancer types. Phenoxodiol is a derivative of the isofl...
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