- Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications
[作者：Nagai, R; Murray, DB; Metz, TO; Baynes, JW,期刊：Diabetes, 页码：549-559 , 文章类型： Article，,卷期：2012年61-3]
- This article outlines evidence that advanced glycation end product (AGE) inhibitors and breakers act primarily as chelators, inhibiting metal-catalyzed oxidation reactions that catalyze AGE formation. We then present evi...
- Hepatic TRAF2 Regulates Glucose Metabolism Through Enhancing Glucagon Responses
[作者：Chen, Z; Sheng, L; Shen, H; Zhao, YJ; Wang, SM; Brink, R; Rui, LY,期刊：Diabetes, 页码：566-573 , 文章类型： Article，,卷期：2012年61-3]
- Obesity is associated with intrahepatic inflammation that promotes insulin resistance and type 2 diabetes. Tumor necrosis factor receptor-associated factor (TRAF)2 is a key adaptor molecule that is known to mediate proin...
- Thiazolidinedione Treatment Decreases Oxidative Stress in Spontaneously Hypertensive Heart Failure Rats Through Attenuation of Inducible Nitric Oxide Synthase-Mediated Lipid Radical Formation
[作者：Kadiiska, MB; Bonini, MG; Ruggiero, C; Cleland, E; Wicks, S; Stadler, K,期刊：Diabetes, 页码：586-596 , 文章类型： Article，,卷期：2012年61-3]
- The current study was designed to test the hypothesis that inducible nitric oxide synthase (iNOS)-mediated lipid free radical overproduction exists in an insulin-resistant rat model and that reducing the accumulation of ...
- Bioactives of Artemisia dracunculus L. Mitigate the Role of Ceramides in Attenuating Insulin Signaling in Rat Skeletal Muscle Cells
[作者：Obanda, DN; Hernandez, A; Ribnicky, D; Yu, YM; Zhang, XH; Wang, ZQ; Cefalu, WT,期刊：Diabetes, 页码：597-605 , 文章类型： Article，,卷期：2012年61-3]
- Ectopic lipids in peripheral tissues have been implicated in attenuating insulin action in vivo. The botanical extract of Artemisia dracunculus L. (PMI 5011) improves insulin action, yet the precise mechanism is not know...
- Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths A Longitudinal Study
[作者：Giannini, C; Weiss, R; Cali, A; Bonadonna, R; Santoro, N; Pierpont, B; Shaw, M; Caprio, S,期刊：Diabetes, 页码：606-614 , 文章类型： Article，,卷期：2012年61-3]
- We sought to determine whether obese adolescents with high-"normal" 2-h post-oral glucose tolerance test glucose levels display defects in insulin secretion and sensitivity associated with future development of impaired ...
- Heat Shock Protein 60 as a Mediator of Adipose Tissue Inflammation and Insulin Resistance
[作者：Marker, T; Sell, H; Zillessen, P; Glode, A; Kriebel, J; Ouwens, DM; Pattyn, P; Ruige, J; Famulla, S; Roden, M; Eckel, J; Habich, C,期刊：Diabetes, 页码：615-625 , 文章类型： Article，,卷期：2012年61-3]
- The stress protein heat shock protein 60 (Hsp60) induces secretion of proinflammatory mediators from murine adipocytes. This study aimed to study Hsp60 as a mediator of adipose tissue inflammation and skeletal muscle cel...
- Common Variants of IL6, LEPR, and PBEF1 Are Associated With Obesity in Indian Children
[作者：Tabassum, R; Mahendran, Y; Dwivedi, OP; Chauhan, G; Ghosh, S; Marwaha, RK; Tandon, N; Bharadwaj, D,期刊：Diabetes, 页码：626-631 , 文章类型： Article，,卷期：2012年61-3]
- The increasing prevalence of obesity in urban Indian children is indicative of an impending crisis of metabolic disorders. Although perturbations in the secretion of adipokines and inflammatory molecules in childhood obe...
- Free Fatty Acids Block Glucose-Induced beta-Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18
[作者：Pascoe, J; Hollern, D; Stamateris, R; Abbasi, M; Romano, LC; Zou, BB; O'Donnell, CP; Garcia-Ocana, A; Alonso, LC,期刊：Diabetes, 页码：632-641 , 文章类型： Article，,卷期：2012年61-3]
- Pancreatic beta-cell proliferation is infrequent in adult humans and is not increased in type 2 diabetes despite obesity and insulin resistance, suggesting the existence of inhibitory factors. Free fatty acids (FFAs) may...
- Optimal Elevation of beta-Cell 11 beta-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism that Prevents High-Fat Diet Induced beta-Cell Failure
[作者：Turban, S; Liu, XX; Ramage, L; Webster, SP; Walker, BR; Dunbar, DR; Mullins, JJ; Seckl, JR; Morton, NM,期刊：Diabetes, 页码：642-652 , 文章类型： Article，,卷期：2012年61-3]
- Type 2 diabetes ultimately results from pancreatic beta-cell failure. Abnormally elevated intracellular regeneration of glucocorticoids by the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) in fat or l...
- miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets
[作者：Wijesekara, N; Zhang, LH; Kang, MH; Abraham, T; Bhattacharjee, A; Warnock, GL; Verchere, CB; Hayden, MR,期刊：Diabetes, 页码：653-658 , 文章类型： Article，,卷期：2012年61-3]
- Changes in cellular cholesterol affect insulin secretion, and beta-cell-specific deletion or loss-of-function mutations in the cholesterol efflux transporter ATP-binding cassette transporter A1 (ABCA1) result in impaired...
- Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired beta-Cell Function
[作者：Kruit, JK; Wijesekara, N; Westwell-Roper, C; Vanmierlo, T; de Haan, W; Bhattacharjee, A; Tang, RM; Wellington, CL; LutJohann, D; Johnson, JD; Brunham, LR; Verchere, CB; Hayden, MR,期刊：Diabetes, 页码：659-664 , 文章类型： Article，,卷期：2012年61-3]
- Cellular cholesterol homeostasis is important for normal beta-cell function. Disruption of cholesterol transport by decreased function of the ATP-binding cassette (ABC) transporter ABCA1 results in impaired insulin secre...
- Markedly Decreased Blood Perfusion of Pancreatic Islets Transplanted Intraportally Into the Liver Disruption of Islet Integrity Necessary for Islet Revascularization
[作者：Henriksnas, J; Lau, J; Zang, GX; Berggren, PO; Kohler, M; Carlsson, PO,期刊：Diabetes, 页码：665-673 , 文章类型： Article，,卷期：2012年61-3]
- Experimental studies indicate low revascularization of intraportally transplanted islets. This study aimed to quantify, for the first time, the blood perfusion of intrahepatically transplanted islets and elucidate necess...
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