- Zernike Phase Contrast Cryo-Electron Microscopy and Tomography for Structure Determination at Nanometer and Subnanometer Resolutions
[作者:Murata, K; Liu, XA; Danev, R; Jakana, J; Schmid, MF; King, J; Nagayama, K; Chiu, W,期刊:Structure, 页码:903-912 , 文章类型: Article,,卷期:2010年18-8]
- Zernike phase contrast cryo-electron microscopy (ZPC-cryoEM) is an emerging technique that is capable of producing higher image contrast than conventional cryoEM. By combining this technique with advanced image processin...
- Structural and Functional Studies of Ig alpha beta and Its Assembly with the B Cell Antigen Receptor
[作者:Radaev, S; Zou, Z; Tolar, P; Nguyen, K; Nguyen, A; Krueger, PD; Stutzman, N; Pierce, S; Sun, PD,期刊:Structure, 页码:934-943 , 文章类型: Article,,卷期:2010年18-8]
- The B cell antigen receptor (BCR) plays an essential role in all phases of B cell development. Here we show that the extracellular domains of murine and human Ig beta form an I-set immunoglobulin-like structure with an i...
- Conserved beta-Hairpin Recognition by the GYF Domains of Smy2 and GIGYF2 in mRNA Surveillance and Vesicular Transport Complexes
[作者:Ash, MR; Faelber, K; Kosslick, D; Albert, GI; Roske, Y; Kofler, M; Schuemann, M; Krause, E; Freund, C,期刊:Structure, 页码:944-954 , 文章类型: Article,,卷期:2010年18-8]
- The yeast suppressor of myosin 2 protein (Smy2) interacts with mRNA-processing proteins through recognition of proline-rich sequences (PRS). Here, we describe the crystal structure of the GYF domain of Smy2 in associatio...
- Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4
[作者:Benirschke, RC; Thompson, JR; Nomine, Y; Wasielewski, E; Juranic, N; Macura, S; Hatakeyama, S; Nakayama, KI; Botuyan, MV; Mer, G,期刊:Structure, 页码:955-965 , 文章类型: Article,,卷期:2010年18-8]
- Human E4B, also called UFD2a, is a U box-containing protein that functions as an E3 ubiquitin ligase and an E4 polyubiquitin chain elongation factor. E4B is thought to participate in the proteasomal degradation of misfol...
- Polycomb Group Targeting through Different Binding Partners of RING1B C-Terminal Domain
[作者:Wang, RJ; Taylor, AB; Leal, BZ; Chadwell, LV; Ilangovan, U; Robinson, AK; Schirf, V; Hart, PJ; Lafer, EM; Demeler, B; Hinck, AP; McEwen, DG; Kim, CA,期刊:Structure, 页码:966-975 , 文章类型: Article,,卷期:2010年18-8]
- RING1B, a Polycomb Group (PcG) protein, binds methylated chromatin through its association with another PcG protein called Polycomb (Pc). However, RING1B can associate with nonmethylated chromatin suggesting an alternate...
- The RaIB-RLIP76 Complex Reveals a Novel Mode of RaI-Effector Interaction
[作者:Fenwick, RB; Campbell, LJ; Rajasekar, K; Prasannan, S; Nietlispach, D; Camonis, J; Owen, D; Mott, HR,期刊:Structure, 页码:985-995 , 文章类型: Article,,卷期:2010年18-8]
- RLIP76 (RaIBP1) is a multidomain protein that interacts with multiple small G protein families: RaI via a specific binding domain, and Rho and R-Ras via a GTPase activating domain. RLIP76 interacts with endocytosis prote...
- Mapping the Interactions between a Major Pollen Allergen and Human IgE Antibodies
[作者:Razzera, G; Gadermaier, G; de Paula, V; Almeida, MS; Egger, M; Jahn-Schmid, B; Almeida, FCL; Ferreira, F; Valente, AP,期刊:Structure, 页码:1011-1021 , 文章类型: Article,,卷期:2010年18-8]
- The interaction of specific IgE antibodies with allergens is a key event in the induction of allergic symptoms, thus representing an important target for therapeutic interventions in Type I allergies. We report here the ...
- The Structural Basis of 5 ' Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain
[作者:Lu, C; Xu, HY; Ranjith-Kumar, CT; Brooks, MT; Hou, TY; Hu, F; Herr, AB; Strong, RK; Kao, CC; Li, PW,期刊:Structure, 页码:1032-1043 , 文章类型: Article,,卷期:2010年18-8]
- RIG-I is a cytosolic sensor of viral RNA that plays crucial roles in the induction of type I interferons. The C-terminal domain (CTD) of RIG-I is responsible for the recognition of viral RNA with 5' triphosphate (ppp). H...
- The Macromolecular Architecture of Extracellular Domain of alpha NRXN1: Domain Organization, Flexibility, and Insights into Trans-Synaptic Disposition
[作者:Comoletti, D; Miller, MT; Jeffries, CM; Wilson, J; Demeler, B; Taylor, P; Trewhella, J; Nakagawa, T,期刊:Structure, 页码:1044-1053 , 文章类型: Article,,卷期:2010年18-8]
- Neurexins are multidomain synaptic cell-adhesion proteins that associate with multiple partnering proteins. Genetic evidence indicates that neurexins may contribute to autism, schizophrenia, and nicotine dependence. Usin...
- Structure and Function of Sphingosine-1-Phosphate Lyase, a Key Enzyme of Sphingolipid Metabolism
[作者:Bourquin, F; Riezman, H; Capitani, G; Grutter, MG,期刊:Structure, 页码:1054-1065 , 文章类型: Article,,卷期:2010年18-8]
- Sphingosine-1-phosphate lyase (SPL), a key enzyme of sphingolipid metabolism, catalyzes the irreversible degradation of sphingoid base phosphates. Its main substrate sphingosine-1-phosphate (S1P) acts both extracellularl...
- Structures of Get3, Get4, and Get5 Provide New Models for TA Membrane Protein Targeting
[作者:Simpson, PJ; Schwappach, B; Dohlman, HG; Isaacson, RL,期刊:Structure, 页码:897-902 , 文章类型: Review,,卷期:2010年18-8]
- The GET pathway, using several proteins (Gets 1-5 and probably Sgt2), posttranslationally conducts tail-anchored (TA) proteins to the endoplasmic reticulum (ER). At the ER, TA proteins are inserted into the lipid bilayer...
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