- Brief Report: Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449.
[作者：Rudin, CM; Hann, CL; Laterra, J; Yauch, RL; Callahan, CA; Fu, L; Holcomb, T; Stinson, J; Gould, SE; Coleman, B; LoRusso, PM; Von Hoff, DD; de Sauvage, FJ; Low, JA,期刊：New England Journal of Medicine, 页码：1173-1178 , 文章类型： Article，,卷期：2009年361-12]
- Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is strongly implicated in the development of some cases of medulloblastoma. A 26-year-old man wi...
- Dabigatran versus Warfarin in Patients with Atrial Fibrillation.
[作者：Connolly, SJ; Ezekowitz, MD; Yusuf, S; Eikelboom, J; Oldgren, J; Parekh, A; Pogue, J; Reilly, PA; Themeles, E; Varrone, J; Wang, S; Alings, M; Xavier, D; Zhu, J; Diaz, R; Lewis, BS; Darius, H; Diener, HC; Joyner, CD; Wallentin, L,期刊：New England Journal of Medicine, 页码：1139-1151 , 文章类型： Article，,卷期：2009年361-12]
- Background: Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor.Methods: In this nonin...
- Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Women and Men.
[作者：Ding, EL; Song, YQ; Manson, JE; Hunter, DJ; Lee, CC; Rifai, N; Buring, JE; Gaziano, JM; Liu, SM,期刊：New England Journal of Medicine, 页码：1152-1163 , 文章类型： Article，,卷期：2009年361-12]
- Background: Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain.Methods: We performed...
- Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma.
[作者：Von Hoff, DD; LoRusso, PM; Rudin, CM; Reddy, JC; Yauch, RL; Tibes, R; Weiss, GJ; Borad, MJ; Hann, CL; Brahmer, JR; Mackey, HM; Lum, BL; Darbonne, WC; Marsters, JC; de Sauvage, FJ; Low, JA,期刊：New England Journal of Medicine, 页码：1164-1172 , 文章类型： Article，,卷期：2009年361-12]
- Background: Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a phase 1 clinical trial, we assessed the safety and...
- Case 29-2009: An 81-Year-Old Man with Weight Loss, Odynophagia, and Failure to Thrive Diffuse large-B-cell lymphoma, consistent with primary hepatic lymphoma, occurring in a patient with HIV infection
[作者：Stone, VE; Bounds, BC; Muse, VV; Ferry, JA,期刊：New England Journal of Medicine, 页码：1189-1198 , 文章类型： Article，,卷期：2009年361-12]
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- A Classic Twin Study of External Ear Malformations, Including Microtia.
[作者：Artunduaga, MA; Quintanilla-Dieck, MDL; Greenway, S; Betensky, R; Nicolau, Y; Hamdan, U; Jarrin, P; Osorno, G; Brent, B; Eavey, R,期刊：New England Journal of Medicine, 页码：1216-1218 , 文章类型： Letter，,卷期：2009年361-12]
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