- Redox Regulation of Mitochondrial ATP Synthase Implications for Cardiac Resynchronization Therapy
[作者：Wang, SB; Foster, DB; Rucker, J; O'Rourke, B; Kass, DA; Van Eyk, JE,期刊：Circulation Research, 页码：750-NIL_117 , 文章类型： Article，,卷期：2011年109-7]
- Rationale: Cardiac resynchronization therapy (CRT) is an effective clinical treatment for heart failure patients with conduction delay, impaired contraction, and energetics. Our recent studies have revealed that mitochon...
- Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart
[作者：Knoll, R; Linke, WA; Zou, PJ; Miocic, S; Kostin, S; Buyandelger, B; Ku, CH; Neef, S; Bug, M; Schafer, K; Knoll, G; Felkin, LE; Wessels, J; Toischer, K; Hagn, F; Kessler, H; Didie, M; Quentin, T; Maier, LS; Teucher, N; Unsold, B; Schmidt, A; Birks, EJ; Gunkel, S; Lang, P; Granzier, H; Zimmermann, WH; Field, LJ; Faulkner, G; Dobbelstein, M; Barton, PJR; Sattler, M; Wilmanns, M; Chien, KR,期刊：Circulation Research, 页码：758-NIL_153 , 文章类型： Article，,卷期：2011年109-7]
- Rationale: Telethonin (also known as titin-cap or t-cap) is a 19-kDa Z-disk protein with a unique beta-sheet structure, hypothesized to assemble in a palindromic way with the N-terminal portion of titin and to constitute...
- Fibroblast Growth Factor Homologous Factor 13 Regulates Na(+) Channels and Conduction Velocity in Murine Hearts
[作者：Wang, C; Hennessey, JA; Kirkton, RD; Wang, CJ; Graham, V; Puranam, RS; Rosenberg, PB; Bursac, N; Pitt, GS,期刊：Circulation Research, 页码：775-NIL_196 , 文章类型： Article，,卷期：2011年109-7]
- Rationale: Fibroblast growth factor homologous factors (FHFs), a subfamily of fibroblast growth factors (FGFs) that are incapable of functioning as growth factors, are intracellular modulators of Na(+) channels and have ...
- PGC-1 beta Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy
[作者：Riehle, C; Wende, AR; Zaha, VG; Pires, KM; Wayment, B; Olsen, C; Bugger, H; Buchanan, J; Wang, XH; Moreira, AB; Doenst, T; Medina-Gomez, G; Litwin, SE; Lelliott, CJ; Vidal-Puig, A; Abel, ED,期刊：Circulation Research, 页码：783-NIL_231 , 文章类型： Article，,卷期：2011年109-7]
- Rationale: Pressure overload cardiac hypertrophy, a risk factor for heart failure, is associated with reduced mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) proteins that correlate in rod...
- Drosophila, Genetic Screens, and Cardiac Function
[作者：Wolf, MJ; Rockman, HA,期刊：Circulation Research, 页码：794-806 , 文章类型： Review，,卷期：2011年109-7]
- The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and signaling for nearly a century, but only over the past few decades has this tremendous resource been the focus of cardiovascular r...
- Cardiovascular Pharmacogenomics
[作者：Roden, DM; Johnson, JA; Kimmel, SE; Krauss, RM; Medina, MW; Shuldiner, A; Wilke, RA,期刊：Circulation Research, 页码：807-820 , 文章类型： Review，,卷期：2011年109-7]
- Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples...
- Exosomes From Human CD34(+) Stem Cells Mediate Their Proangiogenic Paracrine Activity
[作者：Sahoo, S; Klychko, E; Thorne, T; Misener, S; Schultz, KM; Millay, M; Ito, A; Liu, T; Kamide, C; Agrawal, H; Perlman, H; Qin, GJ; Kishore, R; Losordo, DW,期刊：Circulation Research, 页码：724-NIL_35 , 文章类型： Article，,卷期：2011年109-7]
- Rationale: Transplantation of human CD34(+) stem cells to ischemic tissues has been associated with reduced angina, improved exercise time, and reduced amputation rates in phase 2 clinical trials and has been shown to in...
- Fluorescence Resonance Energy Transfer-Based Sensor Camui Provides New Insight Into Mechanisms of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Intact Cardiomyocytes
[作者：Erickson, JR; Patel, R; Ferguson, A; Bossuyt, J; Bers, DM,期刊：Circulation Research, 页码：729-NIL_50 , 文章类型： Article，,卷期：2011年109-7]
- Rationale: Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key mediator of intracellular signaling in the heart. However, the tools currently available for assessing dynamic changes in CaMKII localization an...
- Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-Deficient Mice
[作者：Park, JG; Yoo, JY; Jeong, SJ; Choi, JH; Lee, MR; Lee, MN; Lee, JH; Kim, HC; Jo, H; Yu, DY; Kang, SW; Rhee, SG; Lee, MH; Oh, GT,期刊：Circulation Research, 页码：739-NIL_80 , 文章类型： Article，,卷期：2011年109-7]
- Rationale: Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress.Objective: Although Prdx2 has been proposed to re...
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