- Overexpression of VEGF(165)b, an Inhibitory Splice Variant of Vascular Endothelial Growth Factor, Leads to Insufficient Angiogenesis in Patients With Systemic Sclerosis
[作者：Manetti, M; Guiducci, S; Romano, E; Ceccarelli, C; Bellando-Randone, S; Conforti, ML; Ibba-Manneschi, L; Matucci-Cerinic, M,期刊：Circulation Research, 页码：E14-U35 , 文章类型： Article，,卷期：2011年109-3]
- Rationale: Systemic sclerosis (SSc) is characterized by widespread microangiopathy, fibrosis, and autoimmunity. Despite the lack of angiogenesis, the expression of vascular endothelial growth factor A (VEGF) was shown to...
- Restoration of Normal L-Type Ca2+ Channel Function During Timothy Syndrome by Ablation of an Anchoring Protein
[作者：Cheng, EP; Yuan, C; Navedo, MF; Dixon, RE; Nieves-Cintron, M; Scott, JD; Santana, LF,期刊：Circulation Research, 页码：255-U66 , 文章类型： Article，,卷期：2011年109-3]
- Rationale: L-type Ca2+ (Ca(V)1.2) channels shape the cardiac action potential waveform and are essential for excitation-contraction coupling in heart. A gain-of-function G406R mutation in a cytoplasmic loop of Ca(V)1.2 c...
- Desmoplakin and Talin2 Are Novel mRNA Targets of Fragile X-Related Protein-1 in Cardiac Muscle
[作者：Whitman, SA; Cover, C; Yu, L; Nelson, DL; Zarnescu, DC; Gregorio, CC,期刊：Circulation Research, 页码：262-271 , 文章类型： Article，,卷期：2011年109-3]
- Rationale: The proper function of cardiac muscle requires the precise assembly and interactions of numerous cytoskeletal and regulatory proteins into specialized structures that orchestrate contraction and force transmis...
- Placental Growth Factor Regulates Cardiac Adaptation and Hypertrophy Through a Paracrine Mechanism
[作者：Accornero, F; van Berlo, JH; Benard, MJ; Lorenz, JN; Carmeliet, P; Molkentin, JD,期刊：Circulation Research, 页码：272-U95 , 文章类型： Article，,卷期：2011年109-3]
- Rationale: Paracrine growth factor-mediated crosstalk between cardiac myocytes and nonmyocytes in the heart is critical for programming adaptive cardiac hypertrophy in which myocyte size, capillary density, and the extra...
- A Novel Ryanodine Receptor Mutation Linked to Sudden Death Increases Sensitivity to Cytosolic Calcium
[作者：Meli, AC; Refaat, MM; Dura, M; Reiken, S; Wronska, A; Wojciak, J; Carroll, J; Scheinman, MM; Marks, AR,期刊：Circulation Research, 页码：281-U113 , 文章类型： Article，,卷期：2011年109-3]
- Rationale: Mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT-associated RyR2 mutations cause fatal ventricular arrhythmias in...
- Short Communication: Flecainide Exerts an Antiarrhythmic Effect in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia by Increasing the Threshold for Triggered Activity
[作者：Liu, N; Denegri, M; Ruan, YF; Avelino-Cruz, JE; Perissi, A; Negri, S; Napolitano, C; Coetzee, WA; Boyden, PA; Priori, SG,期刊：Circulation Research, 页码：291-U130 , 文章类型： Article，,卷期：2011年109-3]
- Rationale: Flecainide prevents arrhythmias in catecholaminergic polymorphic ventricular tachycardia, but the antiarrhythmic mechanism remains unresolved. It is possible for flecainide to directly affect the cardiac ryano...
- Autophagy and p62 in Cardiac Proteinopathy
[作者：Zheng, QW; Su, HB; Ranek, MJ; Wang, XJ,期刊：Circulation Research, 页码：296-U164 , 文章类型： Article，,卷期：2011年109-3]
- Rationale: Recent studies suggest an important role of autophagy in protection against alpha B-crystallin-based (CryAB(R120G)) desmin-related cardiomyopathies (DRC), but this has not been demonstrated in a different mode...
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