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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   THERAPEUTIC TARGETS FOR CROHN'S DISEASE [作者：Sorbera, L; Dulsat, C; Rosa, E,期刊：Drugs of the Future, 页码：491-499 , 文章类型： Article，,卷期：2009年34-6] Crohn's disease, one of the most common forms of inflammatory bowel disease (IBD), involves chronic and abnormal activation of the immune system leading to tissue destruction. Although the etiology of the disease is stil... TRAIL AND CANCER THERAPY [作者：Fulda, S,期刊：Drugs of the Future, 页码：485-489 , 文章类型： Review，,卷期：2009年34-6] Programmed cell death, or apoptosis, is a key regulator of tissue homeostasis. Accordingly, imbalances between cell death and proliferation promote tumor formation. TNF-related apoptosis-inducing ligand (TRAIL) is a memb... RIOCIGUAT Soluble Guanylate Cyclase Stimulator Treatment of Pulmonary Hypertension [作者：Mulligan, C,期刊：Drugs of the Future, 页码：468-475 , 文章类型： Article，,卷期：2009年34-6] Pulmonary hypertension (PH) is a debilitating, ultimately fatal disease in which elevated pulmonary arterial pressure causes vascular remodeling, right heart hypertrophy and heart failure. Therapies have only been approv... AEG-35156 Antisense Targeting XIAP Apoptosis Inducer Oncolytic [作者：Cummings, J; Dean, E; Ward, T; Ranson, M; Dive, C,期刊：Drugs of the Future, 页码：437-450 , 文章类型： Article，,卷期：2009年34-6] AEG-35156 is a fully phosphorothioated second-generation 19-mer mixed-bockbone antisense oligonucleotide (ASO) consisting of on 11-nucleotide DNA core flanked at the 3' and 5' ends by four 2'-O-methyl RNA residues. The A... FINAFLOXACIN HYDROCHLORIDE Antibacterial Agent Anti-Helicobacter pylori Agent Quinolone [作者：Vasiliou, S; Vicente, M; Castaner, R,期刊：Drugs of the Future, 页码：451-457 , 文章类型： Article，,卷期：2009年34-6] Finafloxacin hydrochloride, a novel 8-cyano subclass of fluoroquinolone, has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Cram-positive bacterial isolates... IC51 Japanese Encephalitis Vaccine [作者：Jelinek, T; Kaltenbock, A,期刊：Drugs of the Future, 页码：458-467 , 文章类型： Article，,卷期：2009年34-6] Japanese encephalitis (JE), a mosquito-borne arboviral infection, is the leading cause of viral encephalitis in Asia. An annual occurrence of approximately 50,000 sporadic and epidemic cases has been estimated, Vaccines ... FOCAL ADHESION KINASE (FAK) INHIBITION AS A POTENTIAL STRATEGY FOR ANTICANCER THERAPIES [作者：Ma, Y; van de Water, B; Le Devedec, S,期刊：Drugs of the Future, 页码：477-483 , 文章类型： Review，,卷期：2009年34-6] Focal adhesion kinase (FAK) is a multidomain nonreceptor tyrosine kinase that mediates growth factor- and adhesion-derived cell signaling. FAK plays crucial roles in cell proliferation, survival, motility and invasion, a...