- Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis
[作者:Paul, A; Chang, BHJ; Li, L; Yechoor, VK; Chan, L,期刊:Circulation Research, 页码:1492-1501 , 文章类型: Article,,卷期:2008年102-12]
- Foam cells are a hallmark of atherosclerosis. However, it is unclear whether foam cell formation per se protects against atherosclerosis or fuels it. In this study, we investigated the role of adipose differentiation-rel...
- The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription
[作者:Sundberg-Smith, LJ; DiMichele, LA; Sayers, RL; Mack, CP; Taylor, JM,期刊:Circulation Research, 页码:1502-1511 , 文章类型: Article,,卷期:2008年102-12]
- Leupaxin is a LIM domain-containing adapter protein belonging to the paxillin family that has been previously reported to be preferentially expressed in hematopoietic cells. Herein, we identified leupaxin in a screen for...
- Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration
[作者:Clarke, MCH; Littlewood, TD; Figg, N; Maguire, JJ; Davenport, AP; Goddard, M; Bennett, MR,期刊:Circulation Research, 页码:1529-1538 , 文章类型: Article,,卷期:2008年102-12]
- Vascular smooth muscle cell (VSMC) accumulation is implicated in plaque development. In contrast, VSMC apoptosis is implicated in plaque rupture, coagulation, vessel remodeling, medial atrophy, aneurysm formation, and ca...
- A novel human-specific soluble vascular endothelial growth factor receptor 1 - Cell type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia
[作者:Sela, S; Itin, A; Natanson-Yaron, S; Greenfield, C; Goldman-Wohl, D; Yagel, S; Keshet, E,期刊:Circulation Research, 页码:1566-1574 , 文章类型: Article,,卷期:2008年102-12]
- A human-specific splicing variant of vascular endothelial growth factor (VEGF) receptor 1 (Flt1) was discovered, producing a soluble receptor (designated sFlt1-14) that is qualitatively different from the previously desc...
- Nitric oxide-mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone
[作者:Bernal, PJ; Leelavanichkul, K; Bauer, E; Cao, R; Wilson, A; Wasserloos, KJ; Watkins, SC; Pitt, BR; St Croix, CM,期刊:Circulation Research, 页码:1575-1583 , 文章类型: Article,,卷期:2008年102-12]
- The metal binding protein metallothionein (MT) is a target for nitric oxide (NO), causing release of bound zinc that affects myogenic reflex in systemic resistance vessels. Here, we investigate a role for NO-induced zinc...
- Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells
[作者:Jin, S; Hansson, EM; Tikka, S; Lanner, F; Sahlgren, C; Farnebo, F; Baumann, M; Kalimo, H; Lendahl, U,期刊:Circulation Research, 页码:1483-1491 , 文章类型: Article,,卷期:2008年102-12]
- Notch signaling is critically important for proper architecture of the vascular system, and mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with vascular smooth muscle cell (VSMC) dysfunct...
- Inhibition of endothelial nitric oxide synthase activity by proline-rich tyrosine kinase 2 in response to fluid shear stress and insulin
[作者:Fisslthaler, B; Loot, AE; Mohamed, A; Busse, R; Fleming, I,期刊:Circulation Research, 页码:1520-1528 , 文章类型: Article,,卷期:2008年102-12]
- In native and primary cultures of endothelial cells, fluid shear stress elicits the tyrosine phosphorylation of the endothelial NO synthase (eNOS), however, the consequences of this modification on enzyme activity are un...
- The trafficking protein GABARAP binds to and enhances plasma membrane expression and function of the angiotensin II type 1 receptor
[作者:Cook, JL; Re, RN; deHaro, DL; Abadie, JM; Peters, M; Alam, J,期刊:Circulation Research, 页码:1539-1547 , 文章类型: Article,,卷期:2008年102-12]
- Proteins that bind to the intracellular expanses, particularly cytoplasmic tail regions, of heptahelical integral membrane receptors are of particular interest in that they can mediate or modulate trafficking or intracel...
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