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  • The Structure of MESD45-184 Brings Light into the Mechanism of LDLR Family Folding
    [作者:Kohler, C; Lighthouse, JK; Werther, T; Andersen, OM; Diehl, A; Schmieder, P; Du, JG; Holdener, BC; Oschkinat, H,期刊:Structure, 页码:337-348 , 文章类型: Article,,卷期:2011年19-3]
  • Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for the low-density lipoprotein receptor (LDLR) family. Here, we provide evidence that the region 45-184 of MESD is essenti...
  • The Mechanisms of HAMP-Mediated Signaling in Transmembrane Receptors
    [作者:Ferris, HU; Dunin-Horkawicz, S; Mondejar, LG; Hulko, M; Hantke, K; Martin, J; Schultz, JE; Zeth, K; Lupas, AN; Coles, M,期刊:Structure, 页码:378-385 , 文章类型: Article,,卷期:2011年19-3]
  • HAMP domains mediate signal transduction in over 7500 enzyme-coupled receptors represented in all kingdoms of life. The HAMP domain of the putative archaeal receptor Af1503 has a parallel, dimeric, four-helical coiled co...
  • Intrinsic Bending of Microtubule Protofilaments
    [作者:Grafmuller, A; Voth, GA,期刊:Structure, 页码:409-417 , 文章类型: Article,,卷期:2011年19-3]
  • The complex polymerization dynamics of the microtubule (MT) plus end are closely linked to the hydrolysis of the GTP nucleotide bound to the beta-tubulin. The destabilization is thought to be associated with the conforma...
  • Interferon-Inducible Protein 16: Insight into the Interaction with Tumor Suppressor p53
    [作者:Liao, JCC; Lam, R; Brazda, V; Duan, SL; Ravichandran, M; Ma, J; Xiao, T; Tempel, W; Zuo, XB; Wang, YX; Chirgadze, NY; Arrowsmith, CH,期刊:Structure, 页码:418-429 , 文章类型: Article,,卷期:2011年19-3]
  • IFI16 is a member of the interferon-inducible HIN-200 family of nuclear proteins. It has been implicated in transcriptional regulation by modulating protein-protein interactions with p53 tumor suppressor protein and othe...